| Naslov: | Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy : preliminary results of a hybrid approach treatment of pancreatic cancer |
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| Avtorji: | ID Čebron, Žan (Avtor)
ID Djokić, Mihajlo (Avtor)
ID Petrič, Miha (Avtor)
ID Čemažar, Maja (Avtor)
ID Omerzel, Maša (Avtor)
ID Serša, Gregor (Avtor)
ID Trotovšek, Blaž (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (4,65 MB)
MD5: D20A0F70F612F8D23B0104CF901942D3
 URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S156753942300213X
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach. Methods Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks. Results Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%. Conclusions Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible. |
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| Ključne besede: | pancreatic cancer, intraoperative electrochemotherapy, electroporation |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 108576-1-108576-7 |
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| Številčenje: | Vol. 155 |
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| PID: | 20.500.12556/DiRROS-29732  |
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| UDK: | 602.6/.7 |
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| ISSN pri članku: | 1567-5394 |
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| DOI: | 10.1016/j.bioelechem.2023.108576 |
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| COBISS.SI-ID: | 165588227 |
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| Datum objave v DiRROS: | 04.06.2026 |
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| Število ogledov: | 86 |
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| Število prenosov: | 67 |
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| Metapodatki: |    |
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