| Naslov: | Optimised anaesthesia in abdominal cancer surgery does not prevent increase in biomarkers of neuroinflammation |
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| Avtorji: | ID Jenko, Matej (Avtor)
ID Jerin, Aleš (Avtor)
ID Spindler-Vesel, Alenka (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (351,40 KB)
MD5: 9B7B7C1EC685AE0410996C310C1658B7
 URL - Izvorni URL, za dostop obiščite https://doi.org/10.17344/acsi.2024.8901
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Neurocognitive decline during the perioperative period represents a risk of significant complications, including dementia and death. The aim of our study was to observe the change in biomarkers of neuroinflammation in optimized anesthesia without clinical signs of perioperative neurocognitive decline. Observational study included high-risk surgical patients who underwent large intestinal resections. Balanced anaesthesia was used to maximize cerebral protection. The release of NSE, protein S-100, matrix metalloproteinase-9 (MMP-9) and other biomarkers of cerebral injury were measured in serum samples using immunochemical methods during and after surgery. Profiles of proteins MMP-9 and S-100 showed perioperative increase, which was in accordance with intraoperative cerebral injury. Despite the increase, the S-100 and NSE plasma levels remained within normal range. The study highlights the perioperative expression of proteins MMP-9 and S-100, which might be useful as biomarkers of cerebral injury in the context of balanced anesthesia during major abdominal surgery. |
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| Ključne besede: | biomarkers, abdominal cancer surgery, anaesthesia |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2025 |
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| Št. strani: | str. 45-51 |
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| Številčenje: | Vol. 72, no. 1 |
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| PID: | 20.500.12556/DiRROS-27921  |
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| UDK: | 61 |
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| ISSN pri članku: | 1580-3155 |
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| DOI: | 10.17344/acsi.2024.8901 |
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| COBISS.SI-ID: | 236495363 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 20. 5. 2025;
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| Datum objave v DiRROS: | 27.02.2026 |
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| Število ogledov: | 159 |
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| Število prenosov: | 45 |
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| Metapodatki: |    |
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