| Naslov: | Care of patients with non-small-cell lung cancer stage III : the Central European real-world experience |
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| Avtorji: | ID Zemanova, Milada (Avtor)
ID Pirker, Robert (Avtor)
ID Petruželka, Luboš (Avtor)
ID Zbozínkova, Zuzana (Avtor)
ID Rajer, Mirjana (Avtor)
ID Bogos, Krisztina (Avtor)
ID Purkalne, Gunta (Avtor)
ID Ceriman, Vesna (Avtor)
ID Chaudhary, Subhash (Avtor)
ID Richter, Igor (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://content.sciendo.com/view/journals/raon/54/2/article-p209.xml
 PDF - Predstavitvena datoteka, prenos (985,32 KB)
MD5: 76DCE58764E1BB9109A2FACA3AFF0C85
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Background. Management of non-small-cell lung cancer (NSCLC) is affected by regional specificities. The present study aimed at determining diagnostic and therapeutic procedures including outcome of patients with NSCLC stage III in the realworld setting in Central European countries to define areas for improvements. Patients and methods. This multicentre, prospective and non-interventional study collected data of patients with NSCLC stage III in a web-based registry and analysed them centrally. Results. Between March 2014 and March 2017, patients (n=583) with the following characteristics were entered: 32% females, 7% never-smokers; ECOG performance status (PS) 0, 1, 2 and 3 in 25%, 58%, 12% and 5%, respectively; 21% prior weight loss; 53% squamous carcinoma, 38% adenocarcinoma; 10% EGFR mutations. Staging procedures included chest X-ray (97% of patients), chest CT (96%), PET-CT (27%), brain imaging (20%), bronchoscopy (89%), endobronchial ultrasound (EBUS) (13%) and CT-guided biopsy (9%). Stages IIIA/IIIB were diagnosed in 55%/45% of patients, respectively. N2/N3 nodes were diagnosed in 60%/23% and pathologically confirmed in 29% of patients. Most patients (56%) were treated by combined modalities. Surgery plus chemotherapy was administered to 20%, definitive chemoradiotherapy to 34%, chemotherapy only to 26%, radiotherapy only to 12% and best supportive care (BSC) to 5% of patients. Median survival and progression-free survival times were 16.8 (15.3;18.5) and 11.2 (10.2;12.2) months, respectively. Stage IIIA, female gender, no weight loss, pathological mediastinal lymph node verification, surgery and combined modality therapy were associated with longer survival. Conclusions. The real-world study demonstrated a broad heterogeneity in the management o f stage III NSCLC in Central European countries and suggested to increase the rates of PET-CT imaging, brain imaging and invasive mediastinal staging. |
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| Ključne besede: | diagnostic procedures, multimodality treatment, non-small-cell cancer, lung cancer |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.06.2020 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2020 |
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| Št. strani: | str. 209-220, IX |
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| Številčenje: | Vol. 54, no. 2 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19293  |
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| UDK: | 616.2 |
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| ISSN pri članku: | 1318-2099 |
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| COBISS.SI-ID: | 23064579 |
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| Avtorske pravice: | by Authors |
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| Datum objave v DiRROS: | 12.07.2024 |
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| Število ogledov: | 308 |
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| Število prenosov: | 190 |
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| Metapodatki: |    |
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