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Naslov:Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps
Avtorji:ID Soklič, Tanja (Avtor)
ID Rijavec, Matija (Avtor)
ID Šilar, Mira (Avtor)
ID Koren, Ana (Avtor)
ID Kern, Izidor (Avtor)
ID Hočevar-Boltežar, Irena (Avtor)
ID Korošec, Peter (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/downloadpdf/j/raon.ahead-of-print/raon-2019-0029/raon-2019-0029.pdf
 
.pdf PDF - Predstavitvena datoteka, prenos (688,23 KB)
MD5: D8B94F68E4F1A5A99B70D02640EBFD1F
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods. Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically. Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Results. Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. In CRSsNP, we found simultaneous upregulation of T-bet, GATA3 and RORC gene expression levels in comparison to CRSwNP; meanwhile, there was no difference in FOXP3 gene expression between CRSwNP and CRSsNP. Conclusions. In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. The elevated RORC in CRSsNP could be part of homeostatic nasal immune response that might be better preserved in CRSsNP patients compared to CRSwNP patients. Further data on transcription factors expression rates in CRS phenotypes are needed.
Ključne besede:chronic rhinosinusitis
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.09.2019
Založnik:Association of Radiology and Oncology
Leto izida:2019
Št. strani:str. 323-330
Številčenje:Vol. 53, iss. 3
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19169 Novo okno
UDK:616.21
ISSN pri članku:1581-3207
DOI:10.2478/raon-2019-0029 Novo okno
COBISS.SI-ID:2048522353 Novo okno
Avtorske pravice:by Authors
Opomba:Soavtorji: Matija Rijavec, Mira Silar, Ana Koren, Izidor Kern, Irena Hocevar-Boltezar, Peter Korosec; Nasl. z nasl. zaslona; Opis vira z dne 26. 7. 2019;
Datum objave v DiRROS:05.07.2024
Število ogledov:473
Število prenosov:310
Metapodatki:XML DC-XML DC-RDF
:
SOKLIČ, Tanja, RIJAVEC, Matija, ŠILAR, Mira, KOREN, Ana, KERN, Izidor, HOČEVAR-BOLTEŽAR, Irena in KOROŠEC, Peter, 2019, Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps. Radiology and oncology [na spletu]. 2019. Vol. 53, no. 3, p. 323–330. [Dostopano 26 marec 2025]. DOI 10.2478/raon-2019-0029. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=19169
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Naslov:Radiology and oncology
Založnik:Association of Radiology and Oncology
ISSN:1581-3207
COBISS.SI-ID:784507 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:kronični rinosinuzitis


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