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Naslov:Intrahepatic cauda/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swine
Avtorji:ID Jeromel, Miran (Avtor)
ID Pavčnik, Dušan (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (1,02 MB)
MD5: 99256C24CC4ACA4E636661047E69EB34
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. Electrochemotherapy is a local treatment combining application of electric pulses and chemotherapy. Two chemotherapeutic drugs, bleomycin and cisplatin, have proved to be effective in electrochemotherapy. The effectiveness of electrochemotherapy was demonstrated in the treatment of various cutaneous and subcutaneous tumours in cancer patients. Only a few preclinical studies were performed in colorectal carcinoma, mostly using bleomycin. Our aim was to evaluate the sensitivity of the murine colorectal carcinoma cell line CMT-93 to electrochemotherapy with bleomycin and cisplatinfor potential use in preclinical and clinical studies. Methods. CMT-93 cells were exposed to either the chemotherapeutic drug alone or electrochemotherapy. A clonogenic assay was used to determine cell survival after treatment. Apoptosis was measured by caspase-3/7 activity, necrosis by changes in cell morphology and cell viability by the MTS assay 16 hours after electrochemotherapy. Results. Cells treated with electrochemotherapy were 500-fold more sensitive to bleomycin and 2.8-fold more sensitive to cisplatin compared to cells treated with the drugs alone. At the highest concentrations,a significant reduction in cell viability, increase in caspase-3/7 activity and necrotic cells were observed after electrochemotherapy. Conclusions. Exposure of cells to electric pulses enhanced cytotoxicity of both bleomycin and cisplatin. Reduced cell viability was due to apoptotic and necrotic cell death. Furthermore, electrochemotherapywith bleomycin was more cytotoxic than electrochemotherapy with cisplatin in this colorectal carcinoma cell line.
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.09.2010
Založnik:Association of Radiology and Oncology
Leto izida:2010
Št. strani:str. 149-152, II
Številčenje:Letn. 44, št. 3
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18434 Novo okno
UDK:616.1
ISSN pri članku:1318-2099
COBISS.SI-ID:27593433 Novo okno
Avtorske pravice:by Authors
Opomba:BSDOCID154048;
Datum objave v DiRROS:18.03.2024
Število ogledov:724
Število prenosov:149
Metapodatki:XML DC-XML DC-RDF
:
JEROMEL, Miran in PAVČNIK, Dušan, 2010, Intrahepatic cauda/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swine. Radiology and oncology [na spletu]. 2010. Vol. 44, no. 3, p. 149–152, ii. [Dostopano 18 april 2025]. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=18434
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Odsotnost spodnje vene kave z nadaljevanjem poteka vene azygos/hemiazygos. Žilna nepravilnost pri prašičjem živalskem modelu


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