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Naslov:Postoperative radiochemotherapy for gastric adenocarcinoma : long term results
Avtorji:ID Oblak, Irena (Avtor)
ID Anderluh, Franc (Avtor)
ID Velenik, Vaneja (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (94,49 KB)
MD5: 2F9A0BC05850683EB21AE0814A1A5908
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens.
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2009
Založnik:Association of Radiology and Oncology
Leto izida:2009
Št. strani:str. 274-281
Številčenje:Letn. 43, št. 4
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18373 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
COBISS.SI-ID:26682073 Novo okno
Avtorske pravice:by Authors
Opomba:BSDOCID149803;
Datum objave v DiRROS:08.03.2024
Število ogledov:601
Število prenosov:131
Metapodatki:XML DC-XML DC-RDF
:
OBLAK, Irena, ANDERLUH, Franc in VELENIK, Vaneja, 2009, Postoperative radiochemotherapy for gastric adenocarcinoma : long term results. Radiology and oncology [na spletu]. 2009. Vol. 43, no. 4, p. 274–281. [Dostopano 29 marec 2025]. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=18373
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Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Postoperativna radiokemoterapija pri bolnikih z rakom želodca


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