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Naslov: Molecular alterations induced in drug-resistant cells Avtorji: ID Osmak, Maja (Avtor) Datoteke: PDF - Predstavitvena datoteka, prenos (2,17 MB) MD5: 5E8EB6F3BDA79EC90229E36A359F71E4   Jezik: Angleški jezik Tipologija: 1.01 - Izvirni znanstveni članek Organizacija: OI - Onkološki inštitut Ljubljana Povzetek: The major obstacle to the ultimate success in cancer therapy is the ability oftumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/orbetter tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer. Status publikacije: Objavljeno Verzija publikacije: Objavljena publikacija Datum objave: 01.01.1998 Založnik: Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology Leto izida: 1998 Št. strani: str. 19-33 Številčenje: Letn. 32, št. 1 Izvor: Ljubljana PID: 20.500.12556/DiRROS-17904  UDK: 61 ISSN pri članku: 1318-2099 COBISS.SI-ID: 7823065  Avtorske pravice: by Authors Opomba: Life sciences '97 and 2nd Slovenian-Croatian meeting on Molecular oncology today; 1997 Oct 16-19; Gozd Martuljek; BSDOCID37102; Datum objave v DiRROS: 19.01.2024 Število ogledov: 161 Število prenosov: 29 Metapodatki:     Citiraj gradivo Navadno besedilo BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Kopiraj citat

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Gradivo je del revije

Naslov:	Radiology and oncology
Skrajšan naslov:	Radiol. oncol.
Založnik:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

Sekundarni jezik

Jezik:	Slovenski jezik
Naslov:	Molecularne spremembe v celicah rezistentnih na citostatike

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