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Naslov:Genetic polymorphisms of xenobiotic metabolizing enzymes in human colorectal cancer
Avtorji:ID Dolžan, Vita (Avtor)
ID Ravnik-Glavač, Metka (Avtor)
ID Breskvar, Katja (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (1,37 MB)
MD5: 8EABA9DD00518D607F1B1C5AE8C73EF7
 
Jezik:Angleški jezik
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:It was proposed that both hereaditary and environmental factors contribute to the development of colorectal cancer (CRC). Carcinogenic polycyclic aromatic hydrocarbons (PAHs) from food or tobacco smoke can form DNA adducts and thus initiate carcinogenesis after metabolic activation via cytochrome P4501A1 (CYP1A1). Intermediate metabolites are detoxified by conjugation with glutathione S-transferases. Our aim was to look for inherited metabolic suceptibility to CRC. We used PCR-based genotyping approach to determine the frequencies of polymorphic alleles of two cytochromes P450 (CYP2D6 and CYP1A1)and two glutathione S-transferases (GSTM1 and GSTT1) in DNA samples from 31 sporadic, 25 familial CRC cases and 73 healthy controls. The difference in frequencies of poor metabolisers due to CYP2D6 gene polymorphismwas close to the limit of statistical significance between sporadiCRC and healthy control group (lambda 2=5.52, m=2, p=0.06) despite the small sample size. The frequencies of either CYP1A1 MspI, GST M1 or GST T1 genotypes were not significantly different in both CRC cases and in controls. Although our study suggests some difference in metabolic susceptibility between sporadic and familial CRC, further studies are needed to investigate the combined effect of polymorphic genes involved in carcinogen metabolism in a larger group of patients with defined exposure to dietary carcinogens and smoking.
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.1998
Založnik:Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology
Leto izida:1998
Št. strani:str. 35-39
Številčenje:Let. 32, št. 1
Izvor:Ljubljana
PID:20.500.12556/DiRROS-17878 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
COBISS.SI-ID:7555289 Novo okno
Avtorske pravice:by Authors
Opomba:Life sciences '97 and 2nd Slovenian-Croatian meeting on Molecular oncology today; 1997 Oct 16-19; Gozd Martuljek; BSDOCID37103;
Datum objave v DiRROS:19.01.2024
Število ogledov:745
Število prenosov:194
Metapodatki:XML DC-XML DC-RDF
:
DOLŽAN, Vita, RAVNIK-GLAVAČ, Metka in BRESKVAR, Katja, 1998, Genetic polymorphisms of xenobiotic metabolizing enzymes in human colorectal cancer. V : Radiology and oncology [na spletu]. Objavljeni znanstveni prispevek na konferenci. Ljubljana : Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology. 1998. p. 35–39. [Dostopano 15 april 2025]. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=17878
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Genetski polimorfizem encimov, ki presnavljajo ksenobiotike pri kolorektalnem raku


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