| Naslov: | Neuromuscular assessment of force development, postural, and gait performance under cognitive-motor dual-tasking in healthy older adults and early Parkinson's disease patients : study protocol for a cross-sectional Mobile Brain/Body Imaging (MoBI) study |
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| Avtorji: | ID Marušič, Uroš (Avtor)
ID Peskar, Manca (Avtor)
ID Šömen, Maja Maša (Avtor)
ID Kalc, Miloš (Avtor)
ID Holobar, Aleš (Avtor)
ID Gramann, Klaus (Avtor)
ID Wollesen, Bettina (Avtor)
ID Wunderlich, Anna (Avtor)
ID Michel, Christoph M. (Avtor)
ID Miladinović, Aleksandar (Avtor)
ID Catalan, Mauro (Avtor)
ID Stella, Alex B. (Avtor)
ID Ajčević, Miloš (Avtor)
ID Manganotti, Paolo (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.12688/openreseurope.15781.2
 PDF - Predstavitvena datoteka, prenos (1,36 MB)
MD5: 30753A62D30775C107A2B8C6DF82ADC8
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  ZRS Koper - Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria
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| Povzetek: | Background: Neuromuscular dysfunction is common in older adults and more pronounced in neurodegenerative diseases. In Parkinson's disease (PD), a complex set of factors often prevents the effective performance of activities of daily living that require intact and simultaneous performance of the motor and cognitive tasks. Methods: The cross-sectional study includes a multifactorial mixed-measure design. Between-subject factor grouping the sample will be Parkinson’s Disease (early PD vs. healthy). The within-subject factors will be the task complexity (single- vs. dual-task) in each motor activity, i.e., overground walking, semi-tandem stance, and isometric knee extension, and a walking condition (wide vs. narrow lane) will be implemented for the overground walking activity only. To study dual-task (DT) effects, in each motor activity participants will be given a secondary cognitive task, i.e., a visual discrimination task for the overground walking, an attention task for the semi-tandem, and mental arithmetic for the isometric extension. Analyses of DT effects and underlying neuronal correlates will focus on both gait and cognitive performance where applicable. Based on an a priori sample size calculation, a total N = 42 older adults (55-75 years) will be recruited. Disease-specific changes such as laterality in motor unit behavior and cortical control of movement will be studied with high-density surface electromyography and electroencephalography during static and dynamic motor activities, together with whole-body kinematics. Discussion: This study will be one of the first to holistically address early PD neurophysiological and neuromuscular patterns in an ecologically valid environment under cognitive-motor DT conditions of different complexities. The outcomes of the study aim to identify the biomarker for early PD either at the electrophysiological, muscular or kinematic level or in the communication between these systems. |
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| Ključne besede: | Parkinson's disease, mobile brain imaging, body brain imaging, MoBi, dual tasking, neuromuscular function, older adults |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Recenzirani rokopis |
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| Datum objave: | 25.08.2023 |
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| Leto izida: | 2023 |
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| Št. strani: | 14 str. |
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| Številčenje: | Vol. 3, [article no.] ǂ58 |
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| PID: | 20.500.12556/DiRROS-17049  |
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| UDK: | 612.82:612.76 |
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| ISSN pri članku: | 2732-5121 |
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| DOI: | 10.12688/openreseurope.15781.2 |
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| COBISS.SI-ID: | 164659715 |
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| Avtorske pravice: | © 2023 Marusic U et al |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtorji: Manca Peskar, Maja Maša Šömen, Miloš Kalc, Ales Holobar, Klaus Gramann, Bettina Wollesen, Anna Wunderlich, Christoph Michel, Aleksandar Miladinović, Mauro Catalan, Alex Buoite Stella, Milos Ajcevic, Paolo Manganotti;
Opis vira z dne 15. 9. 2023;
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| Datum objave v DiRROS: | 15.09.2023 |
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| Število ogledov: | 771 |
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| Število prenosov: | 335 |
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| Metapodatki: |    |
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