| Naslov: | Interleukin-18 is a potential biomarker linking dietary fatty acid quality and insulin resistance : results from a cross-sectional study in Northern Italy |
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| Avtorji: | ID Sergi, Domenico (Avtor)
ID Sanz, Juana Maria (Avtor)
ID Lazzer, Stefano (Avtor)
ID Brombo, Gloria (Avtor)
ID Zuliani, Giovanni (Avtor)
ID Biolo, Gianni (Avtor)
ID Šimunič, Boštjan (Avtor)
ID Pišot, Rado (Avtor)
ID Dalla Nora, Edoardo (Avtor)
ID Passaro, Angelina (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.3390/nu15071782
 PDF - Predstavitvena datoteka, prenos (1,38 MB)
MD5: 98BB02217003DC184D00ECFB8E3E5274
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  ZRS Koper - Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria
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| Povzetek: | Dietary lipids are pivotal in modulating metabolic inflammation. Among the inflammatory mediators characterizing metabolic inflammation, interleukin 18 (IL-18) has been consistently associated with obesity and insulin resistance. This study aims to evaluate whether the quality of lipid intake impacts upon IL-18 plasma levels and the implications on insulin resistance computed by the homeostatic model assessment for insulin resistance (HOMA-IR). Using a cross-sectional design, this study confirmed that IL-18 correlated positively with insulin resistance and individuals with a HOMA-IR ≥ 2.5 displayed higher circulating IL-18 levels compared with their insulin-sensitive counterparts. In terms of the effect of the quality of dietary lipids on IL-18 circulating levels, the ratio between monounsaturated, omega-3, polyunsaturated and saturated fatty acids as well as the intake of eicosapentaenoic and docosahexaenoic acids correlated negatively with IL-18. Despite this, IL-18 circulating levels, but not dietary fatty acid quality, predicted insulin resistance. Nevertheless, the ratio between omega 3 and saturated fatty acids was a predictor of IL-18 plasma levels. Thus, the downregulation of IL-18 may underpin, at least partially, the beneficial metabolic effects of substituting omega 3 for saturated fatty acids with this cytokine potentially representing a biomarker linking dietary lipids and metabolic outcomes. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum sprejetja članka: | 30.03.2023 |
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| Datum objave: | 06.04.2023 |
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| Leto izida: | 2023 |
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| Št. strani: | 14 str. |
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| Številčenje: | Vol. 15, iss. 7, [article no.] 1782 |
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| PID: | 20.500.12556/DiRROS-16443  |
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| UDK: | 612.015.3 |
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| ISSN pri članku: | 2072-6643 |
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| DOI: | 10.3390/nu15071782 |
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| COBISS.SI-ID: | 149163779 |
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| Avtorske pravice: | © 2023 by the authors |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtorji: Juana Maria Sanz, Stefano Lazzer, Gloria Brombo, Giovanni Zuliani, Gianni Biolo, Boštjan Šimunič, Rado Pišot, Edoardo Dalla Nora, Angelina Passaro;
Opis vira z dne 14. 4. 2023;
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| Datum objave v DiRROS: | 14.04.2023 |
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| Število ogledov: | 916 |
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| Število prenosov: | 363 |
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| Metapodatki: |    |
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