| Naslov: | Neuroendocrine carcinoma of the larynx and pharynx : a clinical and histopathological study |
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| Avtorji: | ID Strojan, Primož (Avtor)
ID Šifrer, Robert (Avtor)
ID Ferlito, Alfio (Avtor)
ID Grašič-Kuhar, Cvetka (Avtor)
ID Lanišnik, Boštjan (Avtor)
ID Plavc, Gaber (Avtor)
ID Zidar, Nina (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2072-6694/13/19/4813
 PDF - Predstavitvena datoteka, prenos (3,97 MB)
MD5: 037DF31D4F05DA593B4B3B77E0C26075
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Neuroendocrine carcinomas (NECs) of the head and neck are rare and the experience scanty. The Cancer Registry of Slovenia database was used to identify cases of laryngeal and pharyngeal NECs diagnosed between 1995%2020. Biopsies were analyzed for the expression of standard neuroendocrine markers (synaptophysin, chromogranin, CD56), INSM1, Ki-67, p16, and PD-L1 (using the combined positive score, CPS). In situ hybridization for human papillomavirus (HPV) and Epstein%Barr virus (EBV) was performed. Twenty patients (larynx, 12; pharynx, 8) were identified. One tumor was well differentiated (WD), five were moderately differentiated (MD), and 14 were poorly differentiated (PD). Disease control was achieved solely by surgery in 4/4 MD/PD T1-2N0-1 tumors. Eight patients died of the disease, seven of which were due to distant metastases. All three traditional markers were positive in 11/17 NECs and the INSM1 marker in all 20 tumors. Two of fourteen p16-positive tumors were HPV-positive, but all three nasopharyngeal NECs were EBV-negative. Three tumors had CPSs % 1. In conclusion, INSM1 was confirmed to be a reliable marker of neuroendocrine differentiation. Except in WD and early-stage MD/PD tumors, aggressive multimodal therapy is needed; the optimal systemic therapy remains to be determined. p16, HPV, and EBV seem to bear no prognostic information. |
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| Ključne besede: | electrochemotherapy, head and neck cancer, neuroendocrinic carcinoma |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 27.09.2021 |
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| Kraj izida: | Basel |
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| Založnik: | MDPI AG |
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| Leto izida: | 2021 |
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| Št. strani: | str. [1-16] |
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| Številčenje: | Vol. 13, no. 19 |
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| PID: | 20.500.12556/DiRROS-15455  |
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| UDK: | 615.82/.84 |
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| ISSN pri članku: | 2072-6694 |
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| COBISS.SI-ID: | 79949315 |
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| Avtorske pravice: | by Authors |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 3. 10. 2021;
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| Datum objave v DiRROS: | 07.09.2022 |
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| Število ogledov: | 861 |
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| Število prenosov: | 394 |
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| Metapodatki: |    |
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