| Naslov: | Heterogeneous response of airway eosinophilia to anti-IL-5 biologics in severe asthma patients |
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| Avtorji: | ID Kopač, Maruša (Avtor)
ID Rijavec, Matija (Avtor)
ID Korošec, Peter (Avtor)
ID Bidovec, Urška (Avtor)
ID Kern, Izidor (Avtor)
ID Vantur, Romana (Avtor)
ID Škrgat, Sabina (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (805,99 KB)
MD5: 2D1E19734BDB21EEC30F6F74C9643323
 URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2075-4426/12/1/70
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
 UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Many questions concerning responders (R) and nonresponders (NR) in severe eosinophilic asthma (SEA) after blocking the IL-5 (interleukin 5) pathway are still not clear, especially regarding the early parameters of response to biologics in personalized treatment strategies. We evaluated 17 SEA patients treated with anti-IL-5 biologics (16 patients mepolizumab, one patient benralizumab) before the introduction of biologics, and at a week 16 follow-up. Clinical, cellular and immunological parameters in peripheral blood were measured in R and NR. Sputum induction with the measurement of cellular and immunological parameters was performed at 16 weeks only. There were 12 R and 5 NR to biologics. After 16 weeks, there was a significant improvement in percentages of FEV1 (p = 0.001), and asthma control test (ACT) (p = 0.001) in the R group, but not in NR. After 16 weeks, the eosinophils in induced sputum were 27.0% in NR and 4.5% in R (p = 0.05), with no difference in IL-5 concentrations (p = 0.743). Peripheral eosinophilia decreased significantly in NR (p = 0.032) and R (p = 0.002). In patients with SEA on anti-IL-5 therapy, there was a marked difference in airway eosinophilic inflammation between R and NR already at 16 weeks, after anti-IL-5 introduction. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.2022 |
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| Kraj izida: | Švica |
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| Založnik: | MDPI |
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| Leto izida: | 2022 |
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| Št. strani: | str. 1-12 |
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| Številčenje: | Vol. 12, iss. 1 |
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| PID: | 20.500.12556/DiRROS-14720  |
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| UDK: | 616.2 |
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| ISSN pri članku: | 2075-4426 |
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| DOI: | 10.3390/jpm12010070 |
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| COBISS.SI-ID: | 92821507 |
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| Avtorske pravice: | © 2022 by the authors |
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| Opomba: | Nasl. z nasl. zaslona;
Maruša Kopač Šokić in Matija Rijavec sta enakovredna prva avtorja;
Opis z dne 11. 1. 2022;
Članek št. 70; |
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| Datum objave v DiRROS: | 13.01.2022 |
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| Število ogledov: | 2648 |
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| Število prenosov: | 1518 |
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| Metapodatki: |    |
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