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Naslov:Hymenoptera venom immunotherapy : immune mechanisms of induced protection and tolerance
Avtorji:ID Demšar Luzar, Ajda, Klinika Golnik (Avtor)
ID Korošec, Peter, Klinika Golnik (Avtor)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Zidarn, Mihaela, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Rijavec, Matija, Klinika Golnik, Biotehniška fakulteta UL (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2073-4409/10/7/1575/pdf
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Hymenoptera venom allergy is one of the most severe allergic diseases, with a considerable prevalence of anaphylactic reaction, making it potentially lethal. In this review, we provide an overview of the current knowledge and recent findings in understanding induced immune mechanisms during different phases of venom immunotherapy. We focus on protection mechanisms that occur early, during the build-up phase, and on the immune tolerance, which occurs later, during and after Hymenoptera venom immunotherapy. The short-term protection seems to be established by the early desensitization of mast cells and basophils, which plays a crucial role in preventing anaphylaxis during the build-up phase of treatment. The early generation of blocking IgG antibodies seems to be one of the main reasons for the lower activation of effector cells. Long-term tolerance is reached after at least three years of venom immunotherapy. A decrease in basophil responsiveness correlates with tolerated sting challenge. Furthermore, the persistent decline in IgE levels and, by monitoring the cytokine profiles, a shift from a Th2 to Th1 immune response, can be observed. In addition, the generation of regulatory T and B cells has proven to be essential for inducing allergen tolerance. Most studies on the mechanisms and effectiveness data have been obtained during venom immunotherapy (VIT). Despite the high success rate of VIT, allergen tolerance may not persist for a prolonged time. There is not much known about immune mechanisms that assure longterm tolerance post-therapy.
Ključne besede:allergy and immunology, hypersensitivity, immunotherapy, immune tolerance, venoms, Hymenoptera, Hymenoptera venom, short-term protection, long-term tolerance
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Kraj izida:Švica
Založnik:MDPI
Leto izida:2021
Št. strani:str. 1-12
Številčenje:Vol. 10, iss. 7
PID:20.500.12556/DiRROS-14263 Novo okno
UDK:616-097
ISSN pri članku:2073-4409
DOI:10.3390/cells10071575 Novo okno
COBISS.SI-ID:68017411 Novo okno
Avtorske pravice:© 2021 by the authors
Opomba:Nasl. z nasl. zaslona; Soavtorji: Peter Korošec, Mitja Košnik, Mihaela Zidarn, Matija Rijavec; Opis vira z dne 23. 6. 2022; Št. članka: 1575;
Datum objave v DiRROS:16.08.2021
Število ogledov:1758
Število prenosov:546
Metapodatki:XML DC-XML DC-RDF
:
DEMŠAR LUZAR, Ajda, KOROŠEC, Peter, KOŠNIK, Mitja, ZIDARN, Mihaela in RIJAVEC, Matija, 2021, Hymenoptera venom immunotherapy : immune mechanisms of induced protection and tolerance. Cells [na spletu]. 2021. Vol. 10, no. 7, p. 1–12. [Dostopano 11 april 2025]. DOI 10.3390/cells10071575. Pridobljeno s: https://www.mdpi.com/2073-4409/10/7/1575/pdf
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Gradivo je del revije

Naslov:Cells
Skrajšan naslov:Cells
Založnik:MDPI
ISSN:2073-4409
COBISS.SI-ID:519958809 Novo okno

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:22.06.2021

Sekundarni jezik

Jezik:Ni določen
Ključne besede:alergija in imunologija, preobčutljivost, imunoterapija, imunska toleranca, živalski strupi, kožekrilci, strup kožekrilcev, kratkotrajna zaščita, dolgotrajna toleranca


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