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Naslov:Reproducibility of malignant pleural mesothelioma histopathologic subtyping
Avtorji:ID Brčić, Luka (Avtor)
ID Vlačić, Gregor, Klinika Golnik (Avtor)
ID Quehenberger, Franz (Avtor)
ID Kern, Izidor, Klinika Golnik (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2017-0295-OA
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Context. Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis. Several studies have analyzed potential prognostic markers, but histologic type remains the single most important prognostic factor. Histologic subtypes of epithelioid MPM seem to have prognostic and therapeutic implications. Interobserver agreement in histologic pattern classification should be high. Objective. To assess interobserver and intraobserver reproducibility in histologic differentiation between the main types of MPMs, and in further subtyping of epithelioid-type mesothelioma. Design. One representative hematoxylin-eosin-stained slide was selected from the archive for each of 200 patients with MPM. They were reviewed independently by 3 pathologists and classified according to the current World Health Organization classification of pleural tumors. After the first round of evaluations, a consensus meeting was organized where problems were addressed and representative images for each histologic category were selected. Two months later, cases were reevaluated by all 3 pathologists. Results. After the first round, overall interobserver agreement for histologic subtyping of mesothelioma was fair (k, 0.36). The agreement was increased to substantial (k, 0.63) in the second round. Improvement was found in interobserver agreement for all types of MPM, and for most epithelioid subtypes. Conclusions. Moderate to substantial agreement in histologic typing and subtyping of MPM can be achieved. However, training with additional clarification of diagnostic criteria, their strict application, and help from consensus-based illustrative images is needed.
Ključne besede:connective and soft tissue neoplasms -- pathology, malignant pleural mesothelioma, histopathology
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Kraj izida:ZDA
Založnik:College of American Pathologists
Leto izida:2018
Št. strani:str. 747-752
Številčenje:Vol. 142, iss. 6
PID:20.500.12556/DiRROS-12792 Novo okno
UDK:616-006
ISSN pri članku:1543-2165
DOI:10.5858/arpa.2017-0295-OA Novo okno
COBISS.SI-ID:2048255345 Novo okno
Avtorske pravice:© 2018 College of American Pathologists
Opomba:Soavtorji: Gregor Vlacic, Franz Quehenberger, Izidor Kern; Nasl. z nasl. zaslona; Opis vira z dne 8. 3. 2018;
Datum objave v DiRROS:30.11.2020
Število ogledov:6527
Število prenosov:637
Metapodatki:XML DC-XML DC-RDF
:
BRČIĆ, Luka, VLAČIĆ, Gregor, QUEHENBERGER, Franz in KERN, Izidor, 2018, Reproducibility of malignant pleural mesothelioma histopathologic subtyping. Archives of pathology & laboratory medicine [na spletu]. 2018. Vol. 142, no. 6, p. 747–752. [Dostopano 19 marec 2025]. DOI 10.5858/arpa.2017-0295-OA. Pridobljeno s: http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2017-0295-OA
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Gradivo je del revije

Naslov:Archives of pathology & laboratory medicine
Skrajšan naslov:Arch. pathol. lab. med.
Založnik:College of American Pathologists
ISSN:1543-2165
COBISS.SI-ID:519009817 Novo okno

Sekundarni jezik

Jezik:Ni določen
Ključne besede:novotvorbe vezivnih in mehkih tkiv -- patologija, maligni plevralni mezoteliom, histopatologija


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