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Reliability improvements for in-wheel motor
Gašper Petelin, Rok Hribar, Stane Ciglarič, Jernej Herman, Anton Biasizzo, Peter Korošec, Gregor Papa, 2024, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Povzetek: Setting up a reliable electric propulsion system in the automotive sector requires an intelligent condition monitoring device capable of reliably assessing the state and the health of the electric motor. To allow for a massive integration of such monitoring devices, they must be inexpensive and small. These requirements limit their accuracy. However, we show in this chapter that these limitations can be significantly reduced by appropriate processing of the sensor data. We have used machine learning models (random forest and XGBoost) to transform very noisy motor winding insulation resistance measurements made by a low-cost device into a much more reliable value that can compete with measurements made by a high-priced state-of-the-art measurement system. The proposed method is an important building block for a future smart condition monitoring system and enables a cost-effective and accurate assessment of the condition of electric motor health in connection with the condition of their winding insulation.
Ključne besede: machine learning models, low-cost device, electric motor
Objavljeno v DiRROS: 23.07.2024; Ogledov: 172; Prenosov: 77
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Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity
Vesna Todorović, Ajda Prevc, Martina Nikšić Žakelj, Monika Savarin, Simon Buček, Blaž Grošelj, Primož Strojan, Maja Čemažar, Gregor Serša, 2020, izvirni znanstveni članek

Povzetek: . Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The purpose of this study was to evaluate LDHRS and the effect of PLDR irradiation in isogenic HNSCC cells with different radiosensitivity. Materials and methods. Cell survival after different irradiation regimens in isogenic parental FaDu and radioresistant FaDu-RR cells was determined by clonogenic assay; post irradiation cell cycle distribution was studied by flow cytometry; the expression of DNA damage signalling genes was assesed by reverse transcription-quantitative PCR. Results. Radioresistant Fadu-RR cells displayed LDHRS and were more sensitive to PLDR irradiation than parental FaDu cells. In both cell lines, cell cycle was arrested in G2/M phase 5 hours after irradiation. It was restored 24 hours after irradiation in parental, but not in the radioresistant cells, which were arrested in G1-phase. DNA damage signalling genes were under-expressed in radioresistant compared to parental cells. Irradiation increased DNA damage signalling gene expression in radioresistant cells, while in parental cells only few genes were under-expressed. Conclusions. We demonstrated LDHRS in isogenic radioresistant cells, but not in the parental cells. Survival of LDHRSpositive radioresistant cells after PLDR was significantly reduced. This reduction in cell survival is associated with variations in DNA damage signalling gene expression observed in response to PLDR most likely through different regulation of cell cycle checkpoints.
Ključne besede: DNA damage, isogenic cell lines, low dose irradiation, pulsed low dose-rate irradiation, radiosensitivity
Objavljeno v DiRROS: 12.07.2024; Ogledov: 239; Prenosov: 70
.pdf Celotno besedilo (785,25 KB)

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Mechanical properties of high carbon low-density steels
Jiri Hajek, Zbyšek Nový, Ludmila Kucerova, Hana Jirková, Črtomir Donik, Zdeňek Jansa, 2023, izvirni znanstveni članek

Ključne besede: low density steels, heat treatment, tensile test
Objavljeno v DiRROS: 02.02.2024; Ogledov: 476; Prenosov: 231
.pdf Celotno besedilo (10,85 MB)
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Fine particulate matter (PM2.5) exposure assessment among active daily commuters to induce behaviour change to reduce air pollution
Anja Ilenič, Alenka Mauko Pranjić, Nina Zupančič, Radmila Milačič, Janez Ščančar, 2023, izvirni znanstveni članek

Povzetek: Fine particulate matter (PM2.5), a detrimental urban air pollutant primarily emitted by traffic and biomass burning, poses disproportionately significant health risks at relatively limited exposure during commuting. Previous studies have mainly focused on fixed locations when assessing PM2.5 exposure, while neglecting pedestrians and cyclists, who often experience higher pollution levels. In response, this research aimed to independently validate the effectiveness of bicycle-mounted low-cost sensors (LCS) adopted by citizens, evaluate temporal and spatial PM2.5 exposure, and assess associated health risks in Ljubljana, Slovenia. The LCS quality assurance results, verified by co-location field tests by air quality monitoring stations (AQMS), showed comparable outcomes with an average percentage difference of 21.29 %, attributed to humidity-induced nucleation effects. The colder months exhibited the highest air pollution levels (μ = 32.31 μg/m3) due to frequent thermal inversions and weak wind circulation, hindering vertical air mixing and the adequate dispersion of pollutants. Additionally, PM2.5 levels in all sampling periods were lowest in the afternoon (μ = 12.09 μg/m3) and highest during the night (μ = 61.00 μg/m3) when the planetary boundary layer thins, leading to the trapping of pollutants near the surface, thus significantly affecting diurnal and seasonal patterns. Analysis of exposure factors revealed that cyclists were approximately three times more exposed than pedestrians. However, the toxicological risk assessment indicated a minimal potential risk of PM2.5 exposure. The collaborative integration of data from official AQMS and LCS can enhance evidence-based policy-making processes and facilitates the realignment of effective regulatory frameworks to reduce urban air pollution.
Ključne besede: air pollution monitoring, PM2.5 exposure, citizen science, bicycle-mounted low-cost sensors
Objavljeno v DiRROS: 30.01.2024; Ogledov: 535; Prenosov: 218
.pdf Celotno besedilo (2,57 MB)
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Measurement of the chloride resistance of environmentally friendly and durable concrete
Alisa Machner, Marie Helene Bjørndal, Aljoša Šajna, Lucija Hanžič, Yushan Gu, Benoit Bary, Klaartje De Weerdt, 2020, objavljeni znanstveni prispevek na konferenci

Povzetek: The increasing demand for concrete and thereby Portland cement, creates the need for novel low-clinker Portland composite cements. Concretes prepared with such novel composite cements need to show similar or even improved durability compared to concrete prepared with commonly used Portland composite cements. This study represents a part of the EnDurCrete project that focuses on the durability of concrete produced with novel low-clinker cements, containing high-value industrial by-products. More specifically, we investigated the chloride ingress resistance of such concrete. Concrete cylinders were submitted to chloride ingress by bulk diffusion. The chloride ingress resistance was investigated on concrete samples by %XRF scanning and chloride titration. In addition, the chloride binding capacity of these novel binders was investigated on paste samples by determining chloride binding isotherms for both binders. In the next step of the project, these experimental results will be matched with an advanced model, which is being developed within the project. By combining modelling with experimental verification, we aim to reach a better understanding of the fundamental chloride ingress mechanisms acting on novel types of concrete. The overall goal of the work is to produce a concrete with lower cost, lower environmental footprint and with verified similar or improved durability.
Ključne besede: chloride ingress, durability, novel binders, Low C02, sustainability, concrete
Objavljeno v DiRROS: 19.01.2024; Ogledov: 506; Prenosov: 228
.pdf Celotno besedilo (18,89 MB)
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Next-generation sequencing of drug resistant Mycobacterium tuberculosis clinical isolates in low-incidence countries
Eva Sodja, Nataša Toplak, Simon Koren, Minka Kovač, Sara Truden, Biljana Ilievska Poposka, Marija Žolnir-Dovč, 2019, izvirni znanstveni članek

Povzetek: Drug resistant tuberculosis (TB), especially multidrug (MDR) and extensively drug-resistant (XDR) TB, is still a serious problem in global TB control. Slovenia and North Macedonia are low-incidence countries with TB incidence rates of 5.4 and 10.4 in 2017, respectively. In both countries, the percentage of drug resistant TB is very low with sporadic cases of MDR-TB. However, global burden of drug-resistant TB continues to increase imposing huge impact on public health systems and strongly stimulating the detection of gene variants related with drug resistance in TB. Next-generation sequencing (NGS) can provide comprehensive analysis of gene variants linked to drug resistance in Mycobacterium tuberculosis. Therefore, the aim of our study was to examine the feasibility of a full-length gene analysis for the drug resistance related genes (inhA, katG, rpoB, embB) using Ion Torrent technology and to compare the NGS results with those obtained from conventional phenotypic drug susceptibility testing (DST) in TB isolates. Between 1996 and 2017, we retrospectively selected 56 TB strains from our National mycobacterial culture collection. Of those, 33 TB isolates from Slovenian patients were isolated from various clinical samples and subjected to phenotypic DST testing in Laboratory for Mycobacteria (University Clinic Golnik, Slovenia). The remaining 23 TB isolates were isolated from Macedonian patients and sent to our laboratory for assistance in phenotypic DST testing. TB strains included were either mono-, poly- or multidrug resistant. For control purposes, we also randomly selected five TB strains susceptible to first-line anti-TB drugs. High concordance between genetic (Ion Torrent technology) and standard phenotypic DST testing for isoniazid, rifampicin and ethambutol was observed, with percent of agreement of 77%, 93.4% and 93.3%, sensitivities of 68.2%, 100% and 100%, and specificities of 100%, 80% and 88.2%, respectively. In conclusion, the genotypic DST using Ion Torrent semiconductor NGS successfully predicted drug resistance with significant shortening of time needed to obtain the resistance profiles from several weeks to just a few days.
Ključne besede: drug resistant tuberculosis, next-generation sequencing, low-incidence countries, phenotypic drug susceptibility testing
Objavljeno v DiRROS: 24.07.2020; Ogledov: 2207; Prenosov: 1211
.pdf Celotno besedilo (144,02 KB)
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