1. Vzpostavitev in izvajanje monitoringa koščaka (Austropotamobius torrentium) in koščenca (Austropotamobius pallipes) v letih 2014 in 2015 : projekt ʺVzpostavitev in izvajanje monitoringa populacij izbranih ciljnih vrst rakov v letih 2014 in 2015ʺMarijan Govedič, Aleksandra Lešnik, Vesna Grobelnik, Ali Šalamun, Al Vrezec, Martina Jaklič, Špela Ambrožič Ergaver, Andrej Kapla, 2015, končno poročilo o rezultatih raziskav Povzetek: V okviru naloge “Dodatne raziskave kvalifikacijskih vrst Natura 2000 ter vzpostavitev in izvajanje monitoringa ciljnih vrst rakov v letu 2010 in 2011 (končno poročilo)”, ki jo je po naročilu Ministrstva RS za okolje in prostor izvajal Center za kartografijo favne in flore s sodelovanjem Nacionalnega inštituta za biologijo in zunanjih sodelavcev (Govedič in sod. 2011) je bil predlagan okvirni načrt monitoringa potočnih rakov v Sloveniji. Večji del raziskav je bil takrat opravljen za namene opredelitve novih Natura 2000 območij za koščaka (Austropotamobius torrentium). Večina predlaganih območij iz leta 2011 (Govedič in sod. 2011) je bila v letu 2013 tudi vključena v razširjeno omrežje Natura 2000 (Uradni list RS 33/2013) in kasneje potrjena na Biogeografskem seminarju leta 2014.
V okviru sedanje naloge “Vzpostavitev in izvajanje monitoringa populacij izbranih ciljnih vrst rakov v letih 2014 in 2015” smo izdelali končno metodologijo monitoringa potočnih rakov v Sloveniji, večinoma pa smo sledili predlogu iz leta 2011 (Govedič in sod. 2011). V poročilu so predstavljeni rezultati terenskega dela. Analize populacijskih in distribucijskih trendov še niso mogoče, interpretirali pa smo nekatere izstopajoče rezultate. Glede na prejšnja poročila monitoringa (Govedič in sod. 2007, 2011) smo dopolnili glavne dejavnike ogrožanja potočnih rakov v Sloveniji s predlogi uvedbe nujnega spremljanja v Sloveniji najbolj perečih dejavnikov kot podporo upravljanju območij Natura 2000 za potočne rake.
Ključne besede: raki, razširjenost, Slovenija
Objavljeno v DiRROS: 16.09.2024; Ogledov: 67; Prenosov: 493
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2. In vitro evolution driven by epistasis reveals alternative cholesterol-specific binding motifs of perfringolysin OAleksandra Šakanović, Nace Kranjc, Neža Omersa, Saša Aden, Andreja Kežar, Matic Kisovec, Apolonija Bedina Zavec, Simon Caserman, Robert J. Gilbert, Marjetka Podobnik, Ana Crnković, Gregor Anderluh, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 12.09.2024; Ogledov: 134; Prenosov: 519
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3. Projekt SloWolf : povzetek rezultatov, poročilo za laikeAleksandra Majić Skrbinšek, 2015, druge monografije in druga zaključena dela Povzetek: Cilj projekta je dolgoročno varstvo volkov, njihovega plena in habitata v Sloveniji ter izboljšanje sobivanja ljudi in volkov. Slednji so naravni plenilci prostoživečih parklarjev, ki živijo v slovenskih gozdovih. Živijo v družinah (tropih) in za preživetje potrebujejo velika območja. V Sloveniji je bilo o populacijski dinamiki, kot npr. povprečno število volkov v tropu, velikost teritorijev, število tropov v državi, pred izvajanjem projekta veliko neznanega. Tudi odnos ljudi do volka je zelo različen. V konflikt z volkovi pogosto prihajajo predvsem lovci in rejci drobnice, saj volkovi plenijo lovne vrste divjadi in domače živali, predvsem drobnico. Hkrati pa volkovi predstavljajo simbol divjine in ohranjene narave. Varstvo volkov je tako zaradi navzkrižja interesov, majhne velikosti populacije in zahtevnega spremljanja varstvenega statusa zelo kompleksno. Dolgoročno preživetje te vrste in sobivanje z ljudmi je v Sloveniji odvisno od več prepletenih dejavnikov. Slednje smo preučevali tekom projekta, se neposredno ukvarjali z najbolj perečimi med njimi, pridobili zajetno količino novega znanja, povezali najpomembneješe interesne skupine za varstvo volka, pomagali izboljšati zakonodajo in tako s kombinacijo vsega tega pripravili trdno osnovo za uspešno varstvo in upravljanje te karizmatične velike zveri v prihodnje
Ključne besede: volkovi, projekti
Objavljeno v DiRROS: 04.09.2024; Ogledov: 111; Prenosov: 76
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4. Project SloWolf : summary of resultsAleksandra Majić Skrbinšek, 2015, druge monografije in druga zaključena dela Povzetek: The goal of the project was the long-term conservation of the wolves, their main prey and habitats in Slovenia, and improvement of their coexistence with humans. Wolves are natural predators of wild ungulates living in Slovenian forests. They live in family groups (packs) and require large territories to survive. In Slovenia many important population-specific life history details, for example the average number of animals a pack, territory sizes and the number of packs living in the country, were unknown before the project implementation. The attitudes of people towards wolves vary greatly as well. Certain interest groups, for example hunters and livestock breeders, may come into conflict with wolves because they prey on game species and domestic sheep. At the same time wolves are increasingly perceived as symbols of wild and preserved nature. These conflicting interests, coupled with low population sizes and demanding monitoring of conservation status, make wolf conservation a very complex issue. Continued existence of this species in Slovenia, and its co-existence with humans, depends on a number of intertwined factors. We studied these factors within the project, directly addressed many of the most pressing issues, produced a solid knowledge base, networked the most important interest groups, helped improve the lacking legislature, and by doing that provided a firm foundation for successful conservation and management of this charismatic large carnivore species in the future.
Objavljeno v DiRROS: 04.09.2024; Ogledov: 102; Prenosov: 77
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5. Complexity of 2-rainbow total domination problemTadeja Kraner Šumenjak, Aleksandra Tepeh, 2024, izvirni znanstveni članek Povzetek: In this paper,we extend the findings of recent studies on $k$-rainbow total domination by placing our focus on its computational complexity aspects. We show that the problem of determining whether a graph has a $2$-rainbow total dominating function of a given weight is NP-complete. This complexity result holds even when restricted to planar graphs. Along the way tight bounds for the $k$-rainbow total domination number of rooted product graphs are established. In addition, we obtain the closed formula for the $k$-rainbow total domination number of the corona product $G ∗ H$, provided that $H$ has enough vertices.
Ključne besede: domination, rainbow domination, rooted product, NP-complete
Objavljeno v DiRROS: 26.08.2024; Ogledov: 140; Prenosov: 68
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6. Sequestration of membrane cholesterol by cholesterol-binding proteins inhibits SARS-CoV-2 entry into Vero E6 cellsMagdalena Kulma, Aleksandra Šakanović, Apolonija Bedina Zavec, Simon Caserman, Neža Omersa, Gašper Šolinc, Sara Orehek, Iva Hafner Bratkovič, Urška Kuhar, Brigita Slavec, Uroš Krapež, Matjaž Ocepek, Toshihide Kobayashi, Katarzyna Kwiatkowska, Roman Jerala, Marjetka Podobnik, Gregor Anderluh, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 05.08.2024; Ogledov: 228; Prenosov: 166
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7. Onkološko zdravstveno svetovanje na daljavoAleksandra Grbič, Dajana Glavan, Sara Brodarič, Irena Oblak, 2024, pregledni znanstveni članek Povzetek: Izhodišče: V začetku leta 2023 smo v okviru klicnega centra vzpostavili zdravstveno svetovanje z namenom opolnomočenja in podpore bolnikov ter njihovih bližnjih. V raziskavi smo analizirali pogostost in stopnjo pojavljanja simptomov, povezanih z boleznijo in zdravljenjem, z uporabo ocenjevalnega protokola in nadaljnjih napotitev glede na izraženost težav.
Metode: Izvedena je bila retrospektivna analiza telefonskih klicev na linijo zdravstvenega svetovanja v klicnem centru od 1. 10. 2023 do 31. 1. 2024. Za zbiranje podatkov o klicateljih je bilo potrjeno in uporabljeno ocenjevalno orodje v podatkovni bazi Redcap. Za izračun odstotnih deležev smo uporabili program Microsoft® Excel® for Office 365 in opisno statistiko.
Rezultati: Vzorec je vključeval 144 telefonskih klicev, kar je predstavljalo 60 % telefonskih klicev bolnikov in 39 % klicev bol-nikovih bližnjih. Vzrok telefonskih klicev je bil v 60,4 % posledica neželenih učinkov sistemskega zdravljenja, ki so bili najpogostejši do tedna dni od prejetja zadnjega zdravljenja. V analizi telefon-skih klicev so bili najpogosteje izraženi simptomi bolečina (10 %), slabost (10 %), izguba apetita (7 %), driska (7 %). Na podlagi tega je bilo izvedenih 144 zdravstvenih svetovanj, 87 napotitev na osebnega zdravnika ali lečečega onkologa in 14 napotitev na nujno medicinsko pomoč.
Zaključek: Zdravstveno svetovanje na daljavo je treba uporabiti kot priložnost za zagotavljanje dostopnosti do informacij in pravo-časne zdravstvene oskrbe prek informacijskih in telekomunikacij-skih sistemov, saj vpliva na spodbujanje samooskrbe, zmanjšanje števila hospitalizacij, znižanje stroškov zdravstvene oskrbe in nenazadnje na kakovost življenja onkoloških bolnikov.
Ključne besede: zdravstveno svetovanje, oddaljen dostop, ocenjevalni triažni protokol
Objavljeno v DiRROS: 26.07.2024; Ogledov: 222; Prenosov: 127
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8. Use of hydrodynamic cavitation in (waste)water treatmentMatevž Dular, Tjaša Griessler Bulc, Ion Gutiérrez-Aguirre, Ester Heath, Tina Kosjek, Aleksandra Krivograd-Klemenčič, Martina Oder, Martin Petkovšek, Nejc Rački, Maja Ravnikar, Andrej Šarc, Brane Širok, Mojca Zupanc, Miha Žitnik, Boris Kompare, 2016, izvirni znanstveni članek Povzetek: The use of acoustic cavitation for water and wastewater treatment (cleaning) is a well known procedure. Yet, the use of hydrodynamic cavitation as a sole technique or in combination with other techniques such as ultrasound has only recently been suggested and employed.
In the first part of this paper a general overview of techniques that employ hydrodynamic cavitation for cleaning of water and wastewater is presented.
In the second part of the paper the focus is on our own most recent work using hydrodynamic cavitation for removal of pharmaceuticals (clofibric acid, ibuprofen, ketoprofen, naproxen, diclofenac, carbamazepine), toxic cyanobacteria (Microcystis aeruginosa), green microalgae (Chlorella vulgaris), bacteria (Legionella pneumophila) and viruses (Rotavirus) from water and wastewater.
As will be shown, hydrodynamic cavitation, like acoustic, can manifest itself in many different forms each having its own distinctive properties and mechanisms. This was until now neglected, which eventually led to poor performance of the technique. We will show that a different type of hydrodynamic cavitation (different removal mechanism) is required for successful removal of different pollutants.
The path to use hydrodynamic cavitation as a routine water cleaning method is still long, but recent results have already shown great potential for optimisation, which could lead to a low energy tool for water and wastewater cleaning.
Ključne besede: wastewater, cleaning, hydrodynamic cavitation, pharmaceuticals, cyanobacteria, microalgae, viruses, Legionella bacteria
Objavljeno v DiRROS: 25.07.2024; Ogledov: 193; Prenosov: 96
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9. Ribociclib plus letrozole in patients with hormone receptor-positive, HER2-negative advanced breast cancer with no prior endocrine therapy : subgroup safety analysis from the phase 3b CompLEEment-1 trialSimona Borštnar, Marketa Palacova, Aleksandra Łacko, Constanta Timcheva, Einav Nili Gal-Yam, Konstantinos Papazisis, Juraj Beniak, Pavol Kudela, Gábor Rubovszky, 2022, izvirni znanstveni članek Povzetek: The CDK4/6 inhibitor, ribociclib in combination with endocrine therapy significantly improved progression-free survival in the first line setting in post-menopausal patients with HR+/HER2- advanced breast cancer (ABC) in a pivotal phase 3, placebo-controlled trial (MONALEESA-2) and demonstrated superior overall survival in premenopausal patients with HR+/HER2- ABC (MONALEESA-7). The multinational, phase 3b, CompLEEment-1 trial, which assessed the safety and efficacy of ribociclib plus letrozole in a broader population of patients who have not received prior endocrine therapy for advanced disease, is the largest phase 3 clinical trial to date to evaluate the safety and efficacy of a CDK4/6 inhibitor. We report a subanalysis of data from patients (N = 339) enrolled in the central and south European countries of the SERCE (Southern Europe, RUC, Central Europe) cluster of CompLEEment-1. Patients and methods: Men and women of any menopausal status with HR+/HER2- ABC received once-daily oral ribociclib 600 mg (3-weeks on/1-week-off), plus letrozole 2.5 mg continuously. Men/premenopausal women also received a GnRH-agonist. The primary outcome was the number of patients with adverse events (AEs) over a timeframe of approximately 36 months. Time-to-progression, overall response rate, and clinical benefit rate were also measured. Results: Safety results in the SERCE subgroup were consistent with those in the pivotal clinical trials of ribociclib in combination with endocrine therapy. Treatment-related AEs leading to dose adjustments/interruption occurred in 63.1% of patients but led to treatment discontinuation in only 10.6%. The most common treatment-related AEs of grade ≥ 3 were neutropenia and transaminase elevations. There were no fatal treatment-related events. Conclusions: These findings from the SERCE subgroup support the safety and manageable tolerability of ribociclib in a broad range of patients with HR+/HER2- ABC more representative of patients in real-world clinical practice.
Ključne besede: CDK4/6 inhibitor, HER2−, HR+, advanced breast cancer, ribociclib
Objavljeno v DiRROS: 24.07.2024; Ogledov: 174; Prenosov: 205
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10. Microstructural, corrosion and mechanical properties of a WE43 alloy : conventional extrusion versus SPDAnna Dobkowska, Aleksandra Zielińska, Irena Paulin, Črtomir Donik, Milena Koralnik, Bogusława Adamczyk-Cieślak, Monika Wieczorek-Czarnocka, Dariusz Kuc, Jiří Kubásek, Tomasz Mikuszewski, Matjaž Godec, Jarosław Mizera, 2024, izvirni znanstveni članek Povzetek: A hexagonal close-packed-structure WE43 alloy was extruded without any preheating of the initial billet using extrusion with an oscillating die to improve the corrosion and mechanical properties. The WE43 alloy was extruded at high ratios of R 1 5:1, R 2 7:1 and R 3 10:1. Electron back-scatter diffraction and transmission electron microscopy were used to determine the microstructural properties of the alloys. The influence of the extrusion method and the extrusion ratios on the corrosion and mechanical properties were investigated. Electrochemical tests were performed, and the corrosion damage was inspected. Tensile tests were made using micro specimens. When compared to conventional extrusion, the microstructural changes obtained with the KoBo method at R 5:1 increased the corrosion resistance, which was not only due to the grain refinement, but also due to the intensity of the texture. A decline in the corrosion resistance of the alloys deformed at higher extrusion ratios was observed. This was a result of the massive plastic strain imposed by the KoBo die. The room-temperature mechanical properties of the KoBo-extruded alloys were improved. However, at higher temperatures the mechanical properties decreased due to the solutioning of tiny triple precipitates.
Ključne besede: WE43, several plastic deformation, microstructure, corrosion, mechanical properties
Objavljeno v DiRROS: 23.07.2024; Ogledov: 213; Prenosov: 69
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