1. Non-contrast computed tomography in the diagnosis of cerebral venous sinus thrombosisJernej Avsenik, Janja Pretnar-Oblak, Katarina Šurlan Popović, 2016, izvirni znanstveni članek Povzetek: Due to the diversity of underlying factors and the absence of a uniform treatment approach, diagnosis and management of patients with cerebral venous sinus thrombosis (CVST) remain a challenging task.1 CVST represents 0.5% to 1% of all strokes and affects approximately 5 patients per million every year, but has a higher frequency among younger patients. Typical acquired risk factors include recent surgery, trauma, pregnancy, postpartum state, antiphospholipid syndrome, cancer and use of oral contraceptives. Cases of inherited thrombophilia include Antithrombin III, Protein C and Protein S deficiency, factor V Leiden positivity, prothrombin gene mutation and hyperhomocisteinemia. Infection of parameningeal spaces (ears, paranasal sinuses, oral cavity, face and neck) is common cause of CVST in pediatric population but rare in adults. The symptoms of CVST are not specific. The most common complaint is headache which occurs in up to 90% of patients. Additionally, abnormal vision, any of the symptoms of stroke and seizures have been described. In the past D-dimer levels appeared to be of value as an initial screening test. A study in 2004 evaluated the sensitivity of D-dimer to be 97.1% and specificity 99.1%.8 However, later studies showed that up to 10% of patients with CVST have a normal D-dimer. As it is fast, affordable and widely available, non-contrast computed tomography (NCCT) is the most frequently performed imaging study for evaluation of patients with new headache, focal neurological abnormalities, seizure, or change in mental status. A typical imaging finding in patients with CVST is direct visualization of a hyperattenuating thrombus in the occluded sinus (dense sinus sign). Occasionally, NCCT may only show indirect signs of thrombosis, including diffuse brain edema and parenchymal hemorrhage. Sensitivity of NCCT in the diagnosis of CVST was previously considered rather poor. However, using modern multidetector row CT scanners, recent studies report higher sensitivity and specificity values. In addition, Buyck et al. suggest measurement of the venous sinus attenuation to increase the diagnostic yield of the examination. Therefore, the goal of the present study was to evaluate the diagnostic accuracy of NCCT in the diagnosis of CVST in the emergency setting
Ključne besede: cerebral venous sinus thrombosis, computed tomography, stroke, radiologija, računalniška tomografija, diagnostika, možganski venski sinusi
Objavljeno v DiRROS: 09.05.2024; Ogledov: 52; Prenosov: 37
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4. Analysis of risk factors for perifocal oedema after endovascular embolization of unruptured intracranial arterial aneurysmsSnezana Lukic, Slobodan Janković, Katarina Šurlan Popović, Dušan Dragič Banković, Peter Popović, Milan Mijailović, 2015, izvirni znanstveni članek Ključne besede: intracranial aneurysms, enovascular embolization, perianeurysmal oedema, hypertension
Objavljeno v DiRROS: 16.04.2024; Ogledov: 76; Prenosov: 27
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5. Imaging findings in bisphosphonate-induced osteonecrosis of the jawsKatarina Šurlan Popović, Miha Kočar, 2010, izvirni znanstveni članek Ključne besede: rak (medicina), bisfosfonati, radiologija, zdravljenje, čeljustnica, nekroze, diagnostika
Objavljeno v DiRROS: 18.03.2024; Ogledov: 93; Prenosov: 35
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6. Interventional radiological management of complications in renal transplantationPeter Popović, Katarina Šurlan Popović, 2004, pregledni znanstveni članek Povzetek: Background. The most frequent radiologically evaluated and treated complications in renal transplantation are perirenal and renal fluid collection and abnormalities of the vasculature and collecting system. Renal and perirenal fluid collection is usually treated successfully with percutaneous drainage. Doppler US, MRA and digital subtraction angiography (DSA) are most important in the evaluation of vascular complications of renal transplantation and management of the endovaseular therapy. Conclusions. Stenosis, the most common vascular complication, occurs in 1% to 12% of transplanted renal arteries and represents a potentially curable cause of hypertension following transplantation and/or renal dysfunction. Treatment with percutaneous transluntinal renal angioplasty (PTRA) or PTRA with stent has been technically successful in 82 to 92% of the cases, and graft salvage rate has ranged from 80-100%. Complications such as arterial and vein thrombosis are uncommon. Intrarenal A/V fistulas and pseudoaneurysms are occasionally seen after biopsy, the treatment reguires superselective embolisation. Urologic complications are relatively uncommon; they consist predominantly of the urinary leaks and urethral obstruction. Interventional treatment consists of percutaneous nephrostomy, balloon dilation, insertion ofthe double J stents, metallic stent placement and external drainage of the extrarenal collections. The aim of the paper is to review the role of interventional radiology in the management of complications in renal transplantation.
Objavljeno v DiRROS: 13.02.2024; Ogledov: 154; Prenosov: 35
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8. Defecography: a report on 35 casesBreda Jamar, Katarina Šurlan Popović, 2000, izvirni znanstveni članek Povzetek: Purpose. To evaluate indications in the patients referred for defecography to our Institute between October 1996 and December 1999. Patients and methods. Inthis period, 35 patients (31 women and 4 men, their mean age being 56,5 and34,5 years, respectively) with defecation disorders disorders of 1 months to 17 years of duration were referred to us for defecography - 26 from proctology specialists and 9 from internal medical out-patient departments. After the rectum was filled with thick barium paste, spot shots from lateral position were made in different phases of defecation, with the patient sittingon a specially designed commode. Results. Rectocele was found in 21 cases, in 9 cases in association with rectorectal intussusception, in 3 with rectoanal intussusception and in 2 with herniation of rectal wall into ishiorectal fossa. Prolapse was found in 2 cases, and 4 rectorectal intussusception, 1 rectoanal intussusception and 3 fistulas were diagnosed. The findings were normal in only one case, while in 3 cases defectography showed functional abnormalities. In female patients, symptoms started after gynaecological operation in 11 cases and 6 cases after delivery. Eight women had to press perineum with their hand to faciliate defecation. Conclusions. Defecography proved useful in clarifying the pathology underlying patient's difficulties.
Objavljeno v DiRROS: 23.01.2024; Ogledov: 180; Prenosov: 41
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9. Dynamic contrast-enhanced MRI in malignant pleural mesothelioma : prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapyMartina Vivoda Tomšič, Peter Korošec, Viljem Kovač, Sotirios Bisdas, Katarina Šurlan Popović, 2022, izvirni znanstveni članek Povzetek: The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is highly desirable. Our aim was to investigate the dynamic contrast-enhanced (DCE) MR parameters as predictors for progression-free (PFS) and overall survival (OS) in patients with MPM treated with cisplatin-based chemotherapy. Methods: Thirty-two consecutive patients with MPM were enrolled in this prospective study. Pretreatment and intratreatment DCE-MRI were scheduled in each patient. The DCE parameters were analyzed using the extended Tofts (ET) and the adiabatic approximation tissue homogeneity (AATH) model. Comparison analysis, logistic regression and ROC analysis were used to identify the predictors for the patient's outcome. Results: Patients with higher pretreatment ET and AATH-calculated Ktrans and ve values had longer OS (P≤.006). Patients with a more prominent reduction in ET-calculated Ktrans and kep values during the early phase of chemotherapy had longer PFS (P =.008). No parameter was identified to predict PFS. Pre-treatment ET-calculated Ktrans was found to be an independent predictive marker for longer OS (P=.02) demonstrating the most favourable discrimination performance compared to other DCE parameters with an estimated sensitivity of 89% and specificity of 78% (AUC 0.9, 95% CI 0.74-0.98, cut off > 0.08 min-1). Conclusions: In the present study, higher pre-treatment ET-calculated Ktrans values were associated with longer OS. The results suggest that DCE-MRI might provide additional information for identifying MPM patients that may respond to chemotherapy.
Ključne besede: cisplatin, magnetic resonance imaging, mesothelioma
Objavljeno v DiRROS: 06.04.2022; Ogledov: 1187; Prenosov: 508
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10. Radiološka slikovna diagnostika gliomov pri odraslihAna Leben, Katarina Šurlan Popović, 2019, ni določena Povzetek: Gliomi so najpogostejši primarni možganski tumorji. Po novih smernicah jih razlikujemo na podlagi molekularnih označevalnikov, kar daje pomembno podlago za razvoj zdravljenja po meri bolnika. Tipizacija tumorjev je lahko invazivna s pomočjo biopsije in neinvazivna. Zadnja v zadnjem času pridobiva veliko vlogo zaradi razvoja radiogenomike, ki preučuje povezavo med slikovnimi fenotipi tumorjev in genomiko. Magnetnoresonančna ocena tumorjev, pri kateri uporabljamo številne standardne in funkcionalne sekvence, omogoča neinvazivno tipizacijo tumorjev glede na specifične morfološke značilnosti posameznih vrst tumorjev s posameznimi molekularnimi označevalci. Po pregledu obstoječe literature so avtorji v članku opisali slikovne značilnosti treh tumorskih genotipov, in sicer mutacije izocitratne dehidrogenaze, kodelecije 1p19q in metilacije promotorja metilgvanin metiltansferaze. Kljub hitremu razvoju radiogenomike primanjkuje obširnih študij z dovolj velikimi in standardiziranimi vzorci bolnikov, ki bi podale zanesljivejše rezultate.
Ključne besede: rak (medicina), gliomi, molekularni markerji, magnetna resonanca, slikovna diagnostika, radiološka diagnostika
Objavljeno v DiRROS: 08.04.2021; Ogledov: 1180; Prenosov: 403
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