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372. The challenge of integrating Life Cycle Assessment in the building design process - a systematic literature review of BIM-LCA workflowsTajda Potrč Obrecht, Martin Röck, Endrit Hoxha, Alexander Passer, 2019, objavljeni znanstveni prispevek na konferenci Povzetek: To foster sustainable development in construction sectors, environmental impacts need to be reduced dramatically. The Life Cycle Assessment (LCA) technique is the most firmly established methodology used to quantify these environmental impacts and, therefore, has been applied with increasing frequency to assess the environmental performance of buildings. To effectively improve a building's environmental performance, an integration of LCA in the design process is required. This can be achieved by coupling LCA with digital design tools, e.g., Building Information Modelling (BIM). To identify the pro and cons of streamlining the integration of LCA and BIM, a comprehensive Systematic Literature Review (SLR) was performed. We identified more than 50 relevant BIM-LCA case studies and analysed the applied BIM-LCA workflows in detail. In most of the studies reviewed, the LCA has been applied in an early design stage. The authors primarily used LCA tools and manual or semi-automatic methods to exchange data between BIM models. In most cases, contemporary BIM-LCA workflows utilized conventional spreadsheets (e.g., Excel worksheets). However, the results of the analysis show that an automated link between LCA and BIM can be achieved if certain challenges are overcome. By automating exchange of information between BIM and LCA tools and improving the reliability of this process, the LCA application can be streamlined in design practice and, hence, the necessary improvements of the environmental performance of buildings can be supported.
Ključne besede: building information modelling, life cycle assessment, systematic Literature Review
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373. Lymphedema following cancer therapy in Slovenia : a frequently overlooked condition?Tanja Planinšek Ručigaj, Nada Kecelj, Vesna Tlaker Žunter, 2010, izvirni znanstveni članek Povzetek: Introduction. Secondary lymphedema following cancer therapy is a frequent, often painful, quality of life disturbing condition, reducing the patients' mobility and predisposing them to complications, e.g. infections and malignancies. The critical aspect of lymphedema therapy is to start as soon aspossible to prevent the irreversible tissue damage. Patients and methods. Weperformed a retrospective study of patients with lymphedema, treated at the Department of Dermatovenereology, University Medical Center Ljubljana, from January 2002 to June 2010. The patientsć demographic and medical data were collected, including type of cancer, type and stage of lymphedema, and time tofirst therapy of lymphedema. The number of referred patients with lymphedema following the therapy of melanoma, breast cancer, and uterine/cervical cancer, was compared to the number of patients expected to experience lymphedema following cancer therapy, calculated from the incidence reported in the literature. Results. In the period of 8.5 years, 543 patients (432 females, 112 males) with lymphedema were treated. The results show that probably many Slovenian patients with secondary lymphedema following cancer therapy remain unrecognized and untreated or undertreated. In the majority of our patients, the management of lymphedema was delayedč on average, the patients first received therapy for lymphedema 3.6 years after the first signsof lymphedema. Conclusions. To avoid a delay in diagnosis and therapy, and the complications of lymphedema following cancer therapy, the physician should actively look for signs or symptoms of lymphedema during the follow-up period, and promptly manage or refer the patients developing problems.
Ključne besede: rak (medicina), zdravljenje, limfedem
Objavljeno v DiRROS: 18.03.2024; Ogledov: 88; Prenosov: 32
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374. Globalization of partial actions of semigroupsGanna Kudryavtseva, Valdis Laan, 2023, izvirni znanstveni članek Povzetek: We propose two universal constructions of globalization of a partial action of a semigroup on a set, satisfying certain conditions which arise in Morita theory of semigroups. One of the constructions is based on the tensor product of a partial semigroup act with the semigroup and generalizes the globalization construction of strong partial actions of monoids due to Megrelishvili and Schröder. It produces the initial object in an appropriate category of globalizations of a given partial action. The other construction involves Hom-sets and is novel even in the monoid setting. It produces the terminal object in an appropriate category of globalizations. While in the group case the results of the two constructions are isomorphic, they can be far different in the monoid case.
Ključne besede: partial action, partial semigroup action, partial monoid action, globalization, enveloping action
Objavljeno v DiRROS: 18.03.2024; Ogledov: 93; Prenosov: 42
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375. Imaging findings in bisphosphonate-induced osteonecrosis of the jawsKatarina Šurlan Popović, Miha Kočar, 2010, izvirni znanstveni članek Ključne besede: rak (medicina), bisfosfonati, radiologija, zdravljenje, čeljustnica, nekroze, diagnostika
Objavljeno v DiRROS: 18.03.2024; Ogledov: 86; Prenosov: 34
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376. Urine and bladder washing cytology for detection of urothelial carcinoma : standard test with new possibilitiesMargareta Strojan Fležar, 2010, pregledni znanstveni članek Povzetek: Background. Light microscopic evaluation of cell morphology in preparations from urine or bladder washing containing exfoliated cells is a standard and primary method for the detection of bladder cancer and also malignancy from other parts of the urinary tract. The cytopathologic examination is a valuablemethod to detect an early recurrence of malignancy or new primary carcinoma during the follow-up of patients after the treatment of bladder cancer. Conclusions. Characteristic cellular and nuclear signs of malignancy indicate invasive or in situ urothelial carcinoma or high-grade papillary urothelial carcinoma. However, low sensitivity of the method reflects the unreliable cytopathologic diagnosis of low-grade urothelial neoplasms as cellular and nuclear signs of malignancy in these neoplasms are poorly manifested. Many different markers were developed to improve the diagnosis of bladder carcinoma on urinary samples. UroVysionT test is among the newest and most promising tests. By the method of in situ hybridization one can detect specific cytogenetic changes of urothelial carcinoma.
Ključne besede: rak (medicina), diagnostika, citološka diagnostika, sečni mehur
Objavljeno v DiRROS: 18.03.2024; Ogledov: 89; Prenosov: 31
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377. Intrahepatic cauda/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swineMiran Jeromel, Dušan Pavčnik, 2010, izvirni znanstveni članek Povzetek: Background. Electrochemotherapy is a local treatment combining application of electric pulses and chemotherapy. Two chemotherapeutic drugs, bleomycin and cisplatin, have proved to be effective in electrochemotherapy. The effectiveness of electrochemotherapy was demonstrated in the treatment of various cutaneous and subcutaneous tumours in cancer patients. Only a few preclinical studies were performed in colorectal carcinoma, mostly using bleomycin. Our aim was to evaluate the sensitivity of the murine colorectal carcinoma cell line CMT-93 to electrochemotherapy with bleomycin and cisplatinfor potential use in preclinical and clinical studies. Methods. CMT-93 cells were exposed to either the chemotherapeutic drug alone or electrochemotherapy. A clonogenic assay was used to determine cell survival after treatment. Apoptosis was measured by caspase-3/7 activity, necrosis by changes in cell morphology and cell viability by the MTS assay 16 hours after electrochemotherapy. Results. Cells treated with electrochemotherapy were 500-fold more sensitive to bleomycin and 2.8-fold more sensitive to cisplatin compared to cells treated with the drugs alone. At the highest concentrations,a significant reduction in cell viability, increase in caspase-3/7 activity and necrotic cells were observed after electrochemotherapy. Conclusions. Exposure of cells to electric pulses enhanced cytotoxicity of both bleomycin and cisplatin. Reduced cell viability was due to apoptotic and necrotic cell death. Furthermore, electrochemotherapywith bleomycin was more cytotoxic than electrochemotherapy with cisplatin in this colorectal carcinoma cell line.
Objavljeno v DiRROS: 18.03.2024; Ogledov: 77; Prenosov: 27
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378. Cubic vertex-transitive graphs admitting automorphisms of large orderPrimož Potočnik, Micael Toledo, 2023, izvirni znanstveni članek Povzetek: A connected graph of order $n$ admitting a semiregular automorphism of order $n/k$ is called a $k$-multicirculant. Highly symmetric multicirculants of small valency have been extensively studied, and several classification results exist for cubic vertex- and arc-transitive multicirculants. In this paper, we study the broader class of cubic vertex-transitive graphs of order $n$ admitting an automorphism of order $n/3$ or larger that may not be semiregular. In particular, we show that any such graph is either a $k$-multicirculant for some $k \le 3$, or it belongs to an infinite family of graphs of girth $6$.
Ključne besede: cubic vertex-transitive graphs, multicirculants, automorphisms of large order
Objavljeno v DiRROS: 18.03.2024; Ogledov: 85; Prenosov: 45
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379. Evaluation of clinical interventions made by pharmacists in chemotherapy preparationLea Knez, Raisa Laaksonen, Catherine Duggan, 2010, izvirni znanstveni članek Povzetek: Background. Cancer drugs are high risk drugs and medication errors in their prescribing, preparation and administration have serious consequences, including death. The importance of a multidisciplinary approach and the benefits of pharmacistsć contribution to cancer treatment to minimise risk have been established. However, the impact of services provided by pharmaciststo cancer patient care is poorly studied. This study explored the clinical interventions made by pharmacists in dispensing of chemotherapy doses, and evaluated pharmacistsć contribution to patient care. Methods. Pharmacists at the Chemotherapy Preparation Unit at a tertiary cancer centre in London were shadowed by two research pharmacists during the clinical screening of chemotherapy prescriptions and release of prepared drugs. An expert panel of pharmacy staff rated the clinical significance of the recordedinterventions. Results. Twenty-one pharmacistsć interventions were recorded during the screening or releasing of 130 prescriptions or drugs. ĆDrug and therapyĆ (38%), ĆclericalĆ (22%) and Ćdose, frequency and durationĆ (19%) related problems most often required an intervention, identifying areas in chemotherapy prescribing that need improvement. The proposed recommendations were implemented in 86% of the cases. Many recorded interventions (48%) were ranked to have had a Ćvery significantĆ influence on patient care. Conclusion. Clinical interventions made by pharmacists had a significant impact on patient care. The integration of pharmacistsć technical and clinical roles into dispensing of chemotherapy doses is required for providing high-quality cancer services.
Objavljeno v DiRROS: 18.03.2024; Ogledov: 99; Prenosov: 27
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