11. Does concurrent gynaecological surgery affect infectious complications rate after mastectomy with implant-based reconstruction?Nina Pišlar, Barbara Perić, Uroš Ahčan, Romi Cencelj-Arnež, Janez Žgajnar, Andraž Perhavec, 2023, izvirni znanstveni članek Povzetek: Background. Women who undergo breast cancer surgery often have an indication for gynaecological procedure. The aim of our study was to compare infectious complications rate after mastectomy with implant-based reconstruc-tion in patients with and without concurrent gynaecological procedure.Patients and methods. We retrospectively reviewed clinical records of 159 consecutively operated patients after mastectomy with implant-based reconstruction. The patients were divided in 2 groups: 102 patients without (Group 1) and 57 with (Group 2) concurrent gynaecological procedure. Infectious complications rates between the groups were compared using χ2-test. Logistic regression was performed to test for association of different variables with infec-tious complications.Results. There were240 breast reconstructions performed. Median follow-up time was 297 days (10–1061 days). Mean patient age was 47.2 years (95% CI 32.8–65.9); 48.2 years (95% CI 46.1–50.3) in Group 1 and 45.8 years (95% CI 43.2–48.3) in Group 2; p = 0.002). Infectious complications rate was 17.6% (17.6% vs. 17.5%, p = 0.987), implant loss occurred in 5.7% (4.9% vs. 7.0%, p = 0.58). Obesity (body mass index[BMI] > 30 kg/m2), age, previous breast conserv-ing treatment (BCT) with radiotherapy (RT) were identified as risk factors for infectious complications in univariate analysis. Obesity (adjusted odds ratio [aOR] 3.319, 95% CI 1.085–10.157, p = 0.036) and BCT with RT (aOR 7.481, 95% CI 2.230–25.101, p = 0.001) were independently associated with infectious complications in multivariate model.Conclusions. Concurrent gynaecological procedure for patients undergoing mastectomy with implant-based re-construction did not carry an increased risk for infectious complications.
Ključne besede: rak na dojki, infekcijski zapleti, rekonstrukcija z vsadki
Objavljeno v DiRROS: 25.07.2024; Ogledov: 192; Prenosov: 110
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12. Identification of women with high grade histopathology results after conisation by artificial neural networksMarko Mlinarič, Miljenko Križmarić, Iztok Takač, Alenka Repše-Fokter, 2022, izvirni znanstveni članek Povzetek: Background: The aim of the study was to evaluate if artificial neural networks can predict high-grade histopathology results after conisation from risk factors and their combinations in patients undergoing conisation because of pathological changes on uterine cervix. Patients and methods: We analysed 1475 patients who had conisation surgery at the University Clinic for Gynaecology and Obstetrics of University Clinical Centre Maribor from 1993-2005. The database in different datasets was arranged to deal with unbalance data and enhance classification performance. Weka open-source software was used for analysis with artificial neural networks. Last Papanicolaou smear (PAP) and risk factors for development of cervical dysplasia and carcinoma were used as input and high-grade dysplasia Yes/No as output result. 10-fold cross validation was used for defining training and holdout set for analysis. Results: Baseline classification and multiple runs of artificial neural network on various risk factors settings were performed. We achieved 84.19% correct classifications, area under the curve 0.87, kappa 0.64, F-measure 0.884 and Matthews correlation coefficient (MCC) 0.640 in model, where baseline prediction was 69.79%. Conclusions: With artificial neural networks we were able to identify more patients who developed high-grade squamous intraepithelial lesion on final histopathology result of conisation as with baseline prediction. But, characteristics of 1475 patients who had conisation in years 1993-2005 at the University Clinical Centre Maribor did not allow reliable prediction with artificial neural networks for every-day clinical practice.
Ključne besede: artificial neural networks, conisation, uterine cervical cancer, uterine cervical dysplasia, displazija materničnega vratu, rak materničnega vratu, konizacija, umetne nevronske mreže
Objavljeno v DiRROS: 24.07.2024; Ogledov: 202; Prenosov: 119
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14. Poročilo o preskusu št.: LVG 2024-074 : vzorec št. 2024/00385Nikica Ogris, Špela Hočevar, Patricija Podkrajšek, Barbara Piškur, 2024, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Fusarium circinatum, Pinus, borov smolasti rak, PCR
Objavljeno v DiRROS: 23.07.2024; Ogledov: 218; Prenosov: 0
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15. Poročilo o preskusu št.: LVG 2024-067 : vzorec št. 2024/00318Nikica Ogris, Špela Hočevar, Zina Devetak, Barbara Piškur, 2024, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, program preiskav, Fusarium circinatum, Pinus, borov smolasti rak, PCR
Objavljeno v DiRROS: 17.07.2024; Ogledov: 213; Prenosov: 0
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16. Poročilo o preskusu št.: LVG 2024-057 : vzorec št. 2024/00240Barbara Piškur, Špela Hočevar, Zina Devetak, 2024, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, program preiskav, Fusarium circinatum, Pinus, borov smolasti rak, PCR
Objavljeno v DiRROS: 24.06.2024; Ogledov: 248; Prenosov: 0
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17. Poročilo o preskusu št.: LVG 2024-048 : vzorec št. 2024/00122Tine Hauptman, Špela Hočevar, Barbara Piškur, 2024, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Fusarium circinatum, Pinus, borov smolasti rak, rtPCR
Objavljeno v DiRROS: 19.06.2024; Ogledov: 233; Prenosov: 0
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20. Spremljanje bolnikov po zaključenem zdravljenju raka debelega črevesa in dankeIrena Oblak, Aleksandra Grbič, 2024, objavljeni strokovni prispevek na konferenci Povzetek: Ob rasti incidence raka, vse kompleksnejšem zdravljenju in vse boljši ozdravljivosti ter eksponentni rasti prevalence bodo potrebe po spremljanju bolnikov z rakom le še naraščale. Običajno tradicionalno intenzivno pet- ali več-letno spremljanje (angl. follow-up) bolnikov po zaključku zdravljenja, ki se izvaja v rednih časovnih intervalih v ustanovi zdravljenja ter vključuje poleg kliničnega pregleda tudi različne slikovne in druge preiskave in merjenje tumorskih označevalcev, potrebuje nadgradnjo in spremembe. Izkazalo se je namreč, da tovrstno intenzivno spremljanje bolnikov nima vpliva na izboljšanje preživetja. Pri bolnikih z rakom debelega črevesa in danke vpliva le na zgodnejše odkritje ponovitve bolezni in več reševalnih operacij, vendar pa le-to nima vpliva na preživetje bolnikov. V okviru spremljanja bolnikov bi se morali bolj približati bolnikovim težavam in potrebam in jih obravnavati celostno od postavitve diagnoze raka, pa ves čas zdravljenja in po njem, in to ne le pet let po zaključku zdravljenja. Obravnava bi morala poleg psiho-fizičnih vidikov vključevati tudi socialnoekonomski ter poklicni vidik. Ob tem je nujna tudi opolnomočenost bolnika, saj mora skrbeti za zdrav življenjski slog, znati premagovati stres, depresijo in anksioznost, poznati svojo bolezen in zdravljenje, možne znake ponovitve bolezni, si želeti čim prejšnje vrnitve nazaj v svoje življenje. Vse to pa presega zmožnosti onkologov, nujna bo večja vključenost družinskih zdravnikov in ostalih strokovnjakov.
Ključne besede: bolniki, rak debelega črevesa in danke, spremljanje bolnikov
Objavljeno v DiRROS: 06.06.2024; Ogledov: 414; Prenosov: 116
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