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Povzetek: The concept of muscle quality encompasses both microand macroscopic aspects of muscle architecture and composition and has gained increasing attention with inclusion in the definition of sarcopenia, indicating the significance of muscle quality in evaluating muscle function and strength among older individuals. Muscle quality consists of two main components: neuromuscular and morphological and is often defined as the ratio between the two. The aim of this review is to present currently used methods for assessment of muscle quality with an emphasis on neuromuscular component in older adults. The most used methods for assessing morphological component are imaging techniques, such as magnetic resonance imaging, computed tomography, dualenergy X-ray absorptiometry and non-imaging bioimpedance analysis. In the neuromuscular component upper and lower body strength are assessed with different methods such as hand grip strength, isokinetic lower limb strength and isometric lower limb strength. Currently, there are three proposed muscle quality assessment methods for field or population studies: muscle quality index, ultrasound sarcopenia index and bioimpedancederived phase angle. Despite the exploration of muscle quality through various assessment methods, a consensus on the most appropriate and universally applicable approach has yet to be established.
Ključne besede: ageing, skeletal muscle, ultrasound sarcopenia index, muscle quality index, phase angle
Objavljeno v DiRROS: 13.05.2024; Ogledov: 29; Prenosov: 10
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Povzetek: Growth factors are key inducers of fibrosis but can also mediate inflammatory responses resulting in increasing pleural effusion and acute respiratory distress syndrome. The primary aim of the study was to analyse growth factors release after performing chemical and mechanical pleurodesis in the first 48 hours at the patients with malignant pleural effusion. The secondary endpoints were to evaluate the effectiveness of the both pleurodeses, symptoms release and the quality of life of patients after the treatment. Patients and methods. A prospective randomized study included 36 consecutive female patients with breast carcinoma and malignant pleural effusion in an intention-to-treat analysis. We treated 18 patients by means of thoracoscopic mechanical pleurodesis and 18 patients by chemical pleurodesis with talcum applied over a chest tube. We gathered the pleural fluid and serum samples in the following 48 hours under a dedicated protocol and tested them for growth factors levels. A quality of life and visual analogue pain score surveys were also performed. Results. Median measured serum vascular endothelial growth factor (VEGF) level after chemical pleurodesis was 930.68 pg/ml (95% CI: 388.22-4656.65) and after mechanical pleurodesis 808.54 pg/ml. (95% CI: 463.20-1235.13) (p = 0.103). Median pleural levels of transforming growth factor (TGF) ß1 were higher after performing mechanical pleurodesis (4814.00 pg/ml [95% CI: 2726.51-7292.94]) when compared to those after performing chemical pleurodesis (1976.50 pg/ml [95% CI: 1659.82-5136.26]) (p = 0.078). We observed similar results for fibroblast growth factor (FGF) ß; the serum level was higher after mechanical pleurodesis (30.45 pg/ml [95% CI: 20.40-59.42]), compared to those after chemical pleurodesis (13.39 pg/ml [95% CI: 5.04-74.60]) (p = 0.076). Mechanical pleurodesis was equally effective as chemical pleurodesis in terms of hospital stay, pleural effusion re-accumulation, requiring of additional thoracentesis, median overall survival, but, it shortened the mean thoracic drainage duration (p = 0.030) and resulted in a higher symptoms release and in a better quality of life (p = 0.047). Conclusions. We recorded an increase in serum VEGF levels after chemical pleurodesis, however on the contrary, an increase in the pleural fluid level of TGF%1 and FGF%] after mechanical pleurodesis with respect to compared group. Although the differences did not reach statistical significance, VEGF, TGFß1 and FGFß remain the most interesting parameters for future research. Considering the mechanisms of growth factors action, we conclude that in our study group mechanical pleurodesis might be more efficient in terms of growth factors release, thoracic drainage duration and resulted in a higher symptoms release and in a better quality of life than chemical pleurodesis.
Ključne besede: malignant pleural effusion, pleurodesis, growth factors, quality of life
Objavljeno v DiRROS: 23.04.2024; Ogledov: 173; Prenosov: 203
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Povzetek: The present work was carried out to obtain and highlight the fifth comprehensive baseline dataset on atmospheric deposition of trace elements and to assess air quality in Macedonia. In the period from August to September 2020, a total of 72 moss samples were collected in accessible areas in the country. The content of 28 elements (Ag, Al, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, K, La, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sb, Sc, Sr, Ti, U, and Zn) was determined using inductively coupled plasma–mass spectrometry. Based on the data obtained on the content of the elements, a factor analysis was carried out to identify and characterise different sources of pollution. In addition, distribution maps were created for all elements to show the regions most affected by anthropogenic activities. The survey conducted in 2020 has shown that air pollution with potentially toxic elements (PTEs) has slightly decreased compared to the results of the previous survey from 2015. This is due to the fact that, despite the operation of all mining and smelting facilities with the same capacity, government regulations for the installation of cleaning systems and additional regulations to reduce pollution have been introduced in the last five years. Nevertheless, the fact remains that the highest anthropogenic air pollution with PTEs is still caused by the operation of the ferronickel smelter in Kavadarci (Ni and Cr) in the southern part and by the lead and zinc mines in Probištip, Makedonska Kamenica, and Kriva Palanka in the eastern part of the country (Cd, Pb, and Zn).
Ključne besede: moss, atmospheric deposition, trace elements, air quality, Macedonia
Objavljeno v DiRROS: 20.03.2024; Ogledov: 292; Prenosov: 306
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Povzetek: As we spend more than 90% of our time inside buildings, indoor environmental quality is a major concern for healthy living. Recent studies show that almost 80% of people in European countries and the United States suffer from SBS (Sick Building Syndrome), which affects physical health, productivity and psychological well-being. In this context, environmental quality monitoring provides stakeholders with crucial information about indoor living conditions, thus facilitating building management along its lifecycle, from design, construction and commissioning to usage, maintenance and end-of-life. However, currently available modelling tools for building management remain limited to static models and lack integration capacities to efficiently exploit environmental quality monitoring data. In order to overcome these limitations, we designed and implemented a generic software architecture that relies on accessible Building Information Model (BIM) attributes to add a dynamic layer that integrates environmental quality data coming from deployed sensors. Merging sensor data with BIM allows creation of a digital twin for the monitored building where live information about environmental quality enables evaluation through numerical simulation. Our solution allows accessing and displaying live sensor data, thus providing advanced functionality to the end-user and other systems in the building. In order to preserve genericity and separation of concerns, our solution stores sensor data in a separate database available through an application programming interface (API), which decouples BIM models from sensor data. Our proof-of-concept experiments were conducted with a cultural heritage building located in Bled, Slovenia. We demonstrated that it is possible to display live information regarding environmental quality (temperature, relative humidity, CO2, particle matter, light) using Revit as an example, thus enabling end-users to follow the conditions of their living environment and take appropriate measures to improve its quality
Ključne besede: Building Information Model, internet of things, environmental quality monitoring, healthy living
Objavljeno v DiRROS: 19.01.2024; Ogledov: 206; Prenosov: 91
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Ključne besede: water quality, forestry, forest ecosystem services, valuation of forest ecosystem services
Objavljeno v DiRROS: 05.10.2023; Ogledov: 292; Prenosov: 97
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