1. Generalized Pell graphsVesna Iršič, Sandi Klavžar, Elif Tan, 2023, izvirni znanstveni članek Povzetek: In this paper, generalized Pell graphs $\Pi_{n,k}$, $k\ge 2$, are introduced. The special case of $k=2$ are the Pell graphs $\Pi_{n}$ defined earlier by Munarini. Several metric, enumerative, and structural properties of these graphs are established. The generating function of the number of edges of $\Pi_{n,k}$ and the generating function of its cube polynomial are determined. The center of $\Pi_{n,k}$ is explicitly described; if $k$ is even, then it induces the Fibonacci cube $\Gamma_{n}$. It is also shown that $\Pi_{n,k}$ is a median graph, and that $\Pi_{n,k}$ embeds into a Fibonacci cube.
Ključne besede: Fibonacci cubes, Pell graphs, generating functions, center of graph, median graphs, k-Fibonacci sequence
Objavljeno v DiRROS: 08.04.2024; Ogledov: 83; Prenosov: 35
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2. Gene sequence variation data for the publication "Synchronous effective population size changes and genetic stability of forest trees through glacial cycles" : version 1.0Tanja Pyhäjärvi, Francesca Bagnoli, Katharina Budde, Stephen Cavers, Sandra Cervantes, Benjamin Dauphin, Bruno Fady, Patricia Faivre-Rampant, Santiago C. González-Martínez, Delphine Grivet, Felix Gugerli, Véronique Jorge, Chedly Kastallya, Martin Lascoux, Isabelle Lesur Kupin, Pascal Milesi, Dario I. Ojeda, Sanna Olsson, Lars Opgenoorth, Sara Pinosio, Christophe Plomion, Christian Rellstab, Odile Rogier, Simone Scalabrin, Ivan Scotti, Giovanni G Vendramin, Marjana Westergren, 2023, zaključena znanstvena zbirka raziskovalnih podatkov Povzetek: This dataset contains the gene sequence variation data (vcf files and their tbi index files) of seven forest tree species used in the manuscript "Synchronous effective population size changes and genetic stability of forest trees through glacial cycles". For each species, between 411 and 651 genotyped trees are included, sampled across Europe in at least 20 locations. Several versions are provided. Species included: Pinus sylvestris, Picea abies, Fagus sylvatica, Populus nigra, Quercus petraea, Pinus pinaster, Betula pendula
Ključne besede: gene sequence, variation data, data set
Objavljeno v DiRROS: 07.03.2023; Ogledov: 555; Prenosov: 561
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3. Multicenter evaluation of the fully automated PCR-based Idylla EGFR Mutation Assay on formalin-fixed, paraffin-embedded Q1 tissue of human lung cancerSolène M. Evrard, Estelle T. Clermont, Isabelle Rouquette, Samuel Murray, Sebastian Dintner, Yun-Chung Nam-Apostolopoulos, Beatriz Bellosillo, Mar V. Rodriguez, Ernest Nadal, Klaus H. Wiedorn, Mitja Rot, Izidor Kern, 2019, izvirni znanstveni članek Povzetek: Before initiating treatment of advanced nonesmall-cell lung cancer with tyrosine kinase inhibitors (eg, erlotinib, gefitinib, osimertinib, and afatinib), which inhibit the catalytic activity of epidermal growth factor receptor (EGFR), clinical guidelines require determining the EGFR mutational status for activating (EGFR exons 18, 19, 20, or 21) and resistance (EGFR exon 20) mutations. The EGFR resistance mutation T790M should be monitored at cancer progression. The Idylla EGFR Mutation Assay, performed on the Idylla molecular diagnostics platform, is a fully automated (<2.5 hours turnaround time) sample-to-result molecular test to qualitatively detect 51 EGFR oncogene point mutations, deletions, or insertions. In a 15- center evaluation, Idylla results on 449 archived formalin-fixed, paraffin-embedded tissue sections, originating from nonesmall-cell lung cancer biopsies and resection specimens, were compared with data obtained earlier with routine reference methods, including next-generation sequencing, Sanger sequencing, pyrosequencing, mass spectrometry, and PCR-based assays. When results were discordant, a third method of analysis was performed, when possible, to confirm test results. After confirmation testing and excluding invalids/errors and discordant results by design, a concordance of 97.6% was obtained between Idylla and routine test results. Even with <10 mm2 of tissue area, a valid Idylla result was obtained in 98.9% of the cases. The Idylla EGFR Mutation Assay enables sensitive detection of most relevant EGFR mutations in concordance with current guidelines, with minimal molecular expertise or infrastructure.
Ključne besede: non-small cell lung carconima -- diagnosis -- genetics, ErbB receptors, sequence analysis, tyrosine kinase inhibitors, epidermal growth factor receptor
Objavljeno v DiRROS: 07.10.2020; Ogledov: 1367; Prenosov: 972
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