1. Long-term survival in glioblastoma : methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factorUroš Smrdel, Mara Popović, Matjaž Zwitter, Emanuela Boštjančič, Andrej Zupan, Viljem Kovač, Damjan Glavač, Drago Bokal, Janja Jerebic, 2016, izvirni znanstveni članek Povzetek: In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status) do not clearly predict long-term survival. The aim of this case-control study was to evaluate immuno-histochemical and genetic characteristics of the tumour as additional prognostic factors in glioblastoma. Long-term survivor group were 40 patients with glioblastoma with survival longer than 30 months. Control group were 40 patients with shorter survival and matched to the long-term survivor group according to the clinical prognostic factors. All patients underwent multimodality treatment with surgery, postoperative conformal radiotherapy and temozolomide during and after radiotherapy. Biopsy samples were tested for the methylation of MGMT promoter (with methylation specific polymerase chain reaction), IDH1 (with immunohistochemistry), IDH2, CDKN2A and CDKN2B (with multiplex ligation-dependent probe amplification), and 1p and 19q mutations (with fluorescent in situ hybridization). Methylation of MGMT promoter was found in 95% and in 36% in the long-term survivor and control groups, respectively (p < 0.001). IDH1 R132H mutated patients had a non-significant lower risk of dying from glioblastoma (p= 0.437), in comparison to patients without this mutation. Other mutations were rare, with no significant difference between the two groups. Molecular and genetic testing offers additional prognostic and predictive information for patients with glioblastoma. The most important finding of our analysis is that in the absence of MGMT promoter methylation, longterm survival is very rare. For patients without this mutation, alternative treatments should be explored.
Ključne besede: glioblastoma, long-term survival, methyl guanine methyl transferase, MGMT, prognostic factor
Objavljeno v DiRROS: 30.04.2024; Ogledov: 34; Prenosov: 11
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2. Hodgkinov limfom : vodnik za bolnikeBarbara Jezeršek Novaković, Samo Zver, Metka Zajc, Aleksandra Grbič, Andreja Cirila Škufca Smrdel, Eda Vrtačnik-Bokal, Vesna Šalamun, Nina Kovačević, Lorna Zadravec-Zaletel, Matej Pečovnik, 2022, ni določena Ključne besede: rak (medicina), krvotvorne matične celice, transplantacija, psihološka pomoč, plodnost, hormonsko nadomestno zdravljenje
Objavljeno v DiRROS: 24.07.2023; Ogledov: 370; Prenosov: 89
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3. Metastatski, na kastracijo odporen rak prostate – kemoterapija, novejša hormonska zdravila in podporno zdravljenjeUrška Bokal, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: Metastatski, na kastracijo odporen rak prostate predstavlja pri bolnikih z rakom prostate zadnjo stopnjo razvoja bolezni. Na prognozo teh bolnikov najbolj vpliva mesto zasevkov; najugodnejšo prognozo imajo bolniki z zasevki le v bezgavkah, najslabšo pa bolniki z zasevki v visceralnih organih. Dva citostatika – docetaksel in kabazitaksel – ter dve novejši hormonski zdravili – enzalutamid in abirateron acetat – podaljšujeta preživetje teh bolnikov. Pomembno je, da jim nudimo tudi dobro podporno zdravljenje, saj se z napredovanjem bolezni breme simptomov stopnjuje, kar poslabšuje kakovost življenja bolnikov.
Ključne besede: rak prostate, onkološko zdravljenje, kastracija
Objavljeno v DiRROS: 03.02.2023; Ogledov: 532; Prenosov: 96
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6. Repository of drought event impacts across the danube catchment countries between 1981 and 2016 using publicly available sourcesJiří Jakubínský, Monika Bláhová, Lenka Bartošová, Klára Steinerová, Jan Balek, Petra Dížková, Daniela Semerádová, Daniel Alexandru, Galia Bardarska, Sabina Bokal, Gregor Gregorič, Gal Oblišar, Andreja Sušnik, 2019, izvirni znanstveni članek Povzetek: Drought directly and indirectly affects human society in a number of ways. In many regions of the world climate change will exasperate the effects of droughts, affect national economies more intensely. The main aim of this article was to catalogue and analyze the drought impacts in the 11 Central and South Eastern European states located in the Danube river basin. The identification of dry episodes was based on information from publicly available sources, namely, newspaper and journal articles that reported drought impacts. Information on drought impact occurrences was classified into one of five defined categories in which the drought impact report was most clearly manifested (i.e., agriculture, forestry, soil systems, wildfires and hydrology). In terms of the spatial distribution of drought impacts, individual recorded events were analyzed at the level of EU NUTS regions (or their equivalent in non-EU countries). The analysis highlights country-specific vulnerability to drought. Furthermore, gradual increases in drought events and the number of reported impacts were identified, which was particularly evident in the agricultural sector.
Ključne besede: drought impact, Danube basin, agriculture, climate change, water stress
Objavljeno v DiRROS: 21.04.2022; Ogledov: 837; Prenosov: 378
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7. Impact of climate change on landslides in Slovenia in the mid-21st centuryMateja Jemec Auflič, Gašper Bokal, Špela Kumelj, Anže Medved, Mojca Dolinar, Jernej Jež, 2021, izvirni znanstveni članek Povzetek: Slovenia is affected by extreme and intense rainfall that triggers numerous landslides every year, resulting in significant human impact and damage to infrastructure. Previous studies on landslides have shown how rainfall patterns can influence landslide occurrence, while in this paper, we present one of the first study in Slovenia to examine the impact of climate change on landslides in the mid-21st century. To do this, we used the Representative Concentration Pathway (RCP) 4.5 climate scenario and future climatology simulated by six climate models that differed from each other as much as possible while representing measured values of past climate variables as closely as possible. Based on baseline period (1981-2010) we showed the number of days with exceedance of rainfall thresholds and the area where landslides may occur more frequently in the projection period (2041-2070). We found that extreme rainfall events are likely to occur more frequent in the future, which may lead to a higher frequency of landslides in some areas.
Ključne besede: climate change, landslides, models, hazard, prediction
Objavljeno v DiRROS: 09.03.2022; Ogledov: 798; Prenosov: 305
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9. Smernice za celostno obravnavo žensk s predrakavimi spremembami materničnega vratuMarjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Borut Kobal, Iztok Takač, Dušan Deisinger, Andrej Zore, 2017, ni določena Ključne besede: ginekologija, onkologija, diagnostika, izvidi, postopki
Objavljeno v DiRROS: 23.06.2020; Ogledov: 1844; Prenosov: 504
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10. Postopki za odkrivanje in obravnavo žensk s predrakavimi spremembami materničnega vratuMarjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Borut Kobal, Iztok Takač, Dušan Deisinger, Andrej Zore, 2011, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Objavljeno v DiRROS: 10.06.2020; Ogledov: 1773; Prenosov: 476
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