31. Digital twins and road construction using secondary raw materialsSebastjan Meža, Alenka Mauko Pranjić, Rok Vezočnik, Igor Osmokrović, Stanislav Lenart, 2021, izvirni znanstveni članek Povzetek: Secondary raw materials (SRMs) tend to be a valuable replacement for finite virgin materials especially since construction works (i.e., building and civil engineering work such as road construction) require vast quantities of raw materials. Using SRM originating from recycling a broad range of inorganic waste materials (e.g., mining waste, different industrial wastes, construction, and demolition waste) has been recognized as a promising, generally more cost-efficient, and environmentally friendly alternative to the exploitation of natural resources. Despite the benefits of using SRM, several challenges need to be addressed before using SRM even more. One of them is the long-term durability and little-known response of construction works built using such alternative materials. In this paper, we present the activities to establish a fully functioning digital twin (DT) of a road constructed using SRM. The first part of the paper is devoted to the theoretical justification of efforts and ways of establishing the monitoring systems, followed by a DT case study where an integrated data environment synthesizing a Building Information Model and monitored data is presented. Although the paper builds upon a small scale, the case study is methodologically designed to allow parallels to be drawn with much larger construction projects.
Ključne besede: digital twins, road construction, circular economy
Objavljeno v DiRROS: 19.07.2023; Ogledov: 288; Prenosov: 195
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32. Advanced method for efficient functionalization of polymers by intermediate free-radical formation with vacuum-ultraviolet radiation and producing superhydrophilic surfacesAlenka Vesel, Rok Zaplotnik, Miran Mozetič, Nina Recek, 2023, izvirni znanstveni članek Povzetek: An efficient approach for tailoring surface properties of polymers is presented, which enables rapid modification leading to superhydrophilic properties. The approach is based on vacuum-ultraviolet radiation (VUV) pretreatment of the surface to create reactive dangling bonds. This step is followed by a second treatment using neutral oxygen atoms that react with the dangling bonds and form functional groups. The beneficial effect of VUV pretreatment for enhanced functionalization was clearly demonstrated by comparing VUV pretreatment in plasmas created in different gases, i.e., hydrogen, nitrogen, and oxygen, which differ in the intensity of VUV/UV radiation. The emission intensity of VUV radiation for all gases was measured by vacuum ultraviolet spectroscopy. It was shown that VUV has a strong influence on the treatment time and final surface wettability. A superhydrophilic surface was obtained only if using VUV pretreatment. Furthermore, the treatment time was significantly reduced to only a second of treatment. These findings show that such an approach may be used to enhance the surface reaction efficiency for further grafting of chemical groups.
Ključne besede: plasma treatment, vacuum-ultraviolet radiation treatment, surface functionalization, polymer polyvinyl chloride, vacuum-ultraviolet spectroscopy, vacuum-ultraviolet photons
Objavljeno v DiRROS: 06.06.2023; Ogledov: 383; Prenosov: 193
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33. Engineered combinatorial cell device for wound healing and bone regenerationLucija Kadunc, Duško Lainšček, Rok Gašperšič, Petra Sušjan, Uroš Kovačič, Miha Butinar, Boris Turk, Roman Jerala, Iva Hafner Bratkovič, 2023, izvirni znanstveni članek Povzetek: Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted growth factors underlies stem cell–mediated regeneration. To avoid the potential dangers and laborintensive individual approach of stem cell therapy while maintaining their regeneration-promoting effects based on multiple secreted growth factors, we engineered a “mix-and-match” combinatorial platform based on a library of cell lines producing growth factors. Treatment with a combination of growth factors secreted by engineered mammalian cells was more efficient than with individual growth factors or even stem cell–conditioned medium in a gap closure assay. Furthermore, we implemented in a mouse model a device for allogenic cell therapy for an in situ production of growth factors, where it improved cutaneous wound healing. Augmented bone regeneration was achieved on calvarial bone defects in rats treated with a cell device secreting IGF, FGF, PDGF, TGF-β, and VEGF. In both in vivo models, the systemic concentration of secreted factors was negligible, demonstrating the local effect of the regeneration device. Finally, we introduced a genetic switch that enables temporal control over combinations of trophic factors released at different stages of regeneration mimicking the maturation of natural wound healing to improve therapy and prevent scar formation.
Ključne besede: wound healing, bone regeneration, growth factors
Objavljeno v DiRROS: 01.06.2023; Ogledov: 495; Prenosov: 193
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34. Forest managers’ perspectives on environmental changes in the biosphere reserve Mura-Drava-DanubeMarcus Sallmannshofer, Rok Damjanić, Harald Vacik, Marjana Westergren, Tjaša Baloh, Gregor Božič, Mladen Ivanković, Gyula Kovács, Miran Lanšćak, Katharina Lapin, Laszlo Nagy, Silvija Krajter Ostoić, Saša Orlović, Srđan Stojnić, Peter Železnik, Milica Zlatković, Silvio Schueler, 2023, izvirni znanstveni članek Povzetek: Riparian forests are particularly vulnerable to environmental change and anthropogenic influences because they are highly dynamic ecosystems, thus proper adaptation measures are crucial. The implementation of these measures, however, strongly depends on the actors’ perceptions of the specific problems occurring in such forests. For understanding the constraints of specific interest groups toward different adaptation activities, information in this field is essential. By conducting a questionnaire survey we explore how different types of forest managers, i.e., forestry professionals, forest owners, and conservation managers, perceive the effects of environmental change on forest management in the recently established Transboundary Biosphere Reserve Mura-Drava-Danube. We show that these forest managers are highly aware of ongoing environmental changes and appraise deteriorating forest conditions, especially after observing changes themselves. Abiotic damage is expected to increase the most, followed by biotic damage, the spread of non-native species, and tree dieback. Nearly 80% of the survey respondents expect further changes and almost all of them intend to adapt their management of forests to mitigate or prepare for these changes. Nevertheless, we show differences in sensitivity to change and willingness to initiate adaptation actions by assessing adaptation thresholds: conservation managers appear generally more tolerant to changes, which results in higher thresholds to initiate management adaptation than forestry professionals
Ključne besede: biosphere reserve Mura-Drava-Danube, forest management, sensitivity to environmental change, stakeholder perception, adaptation thresholds, riparian forest tree species
Objavljeno v DiRROS: 31.05.2023; Ogledov: 365; Prenosov: 281
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36. Sistemsko zdravljenje bolnikov s pljučnim rakom : tarčno zdravljenjeRok Devjak, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: Sistemsko zdravljenje nedrobnoceličnega raka pljuč (NDRP) je odvisno od različnih
biooznačevalcev. Za izbiro sistemskega zdravljenja NDRP, ki nima ploščatocelične
patohistologije danes potrebujemo molekularnogenetsko analizo. Le-ta nam poda
informacijo ali ima NDRP morebitno genetsko alteracijo, za katero že imamo razvito tarčno
obliko zdravljenja. Poznamo naslednje prediktivne molekularne alteracije: mutacije v genih
EGFR, MET, BRAF, KRAS ter preureditve v genih ALK, ROS1, RET, NTRK in še druge. Skupna
lastnost tarčnih zdravil pri NDRP je, da so visoko učinkovita, v peroralni obliki in da nudijo
dobre možnosti dolgotrajnih zazdravljenj napredovale bolezni, ob tem pa je tveganje za hude
neželene učinke nizko, kar celokupno vodi v dobro kvaliteto življenja.
Ključne besede: pljučni rak, onkološko zdravljenje, bolniki
Objavljeno v DiRROS: 12.05.2023; Ogledov: 397; Prenosov: 92
Celotno besedilo (86,27 KB) |
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38. A review of recombination coefficients of neutral oxygen atoms for various materialsDomen Paul, Miran Mozetič, Rok Zaplotnik, Gregor Primc, Denis Đonlagić, Alenka Vesel, 2023, izvirni znanstveni članek Povzetek: Relevant data on heterogeneous surface recombination of neutral oxygen atoms available in the scientific literature are reviewed and discussed for various materials. The coefficients are determined by placing the samples either in non-equilibrium oxygen plasma or its afterglow. The experimental methods used to determine the coefficients are examined and categorized into calorimetry, actinometry, NO titration, laser-induced fluorescence, and various other methods and their combinations. Some numerical models for recombination coefficient determination are also examined. Correlations are drawn between the experimental parameters and the reported coefficients. Different materials are examined and categorized according to reported recombination coefficients into catalytic, semi-catalytic, and inert materials. Measurements from the literature of the recombination coefficients for some materials are compiled and compared, along with the possible system pressure and material surface temperature dependence of the materials’ recombination coefficient. A large scattering of results reported by different authors is discussed, and possible explanations are provided.
Ključne besede: heterogeneous surface recombination, recombination coefficient, surface catalicity, catalytic efficiency, atom loss coefficient, oxygen, neutral atoms, plasma
Objavljeno v DiRROS: 22.02.2023; Ogledov: 481; Prenosov: 229
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39. Prekinitev zdravljenja in reindukcija zdravljenja z imunskimi kontrolnimi točkamiRok Devjak, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: Zaviralci imunskih kontrolnih točk (ZIKT) so novejša oblika sistemskega zdravljenja, ki so povezani s potencialni razvojem imunsko pogojenih neželenih dogodkov (irAE). Po razrešenem irAE obstaja možnost ponovne uvedbe ZIKT. Z naraščenjem števila bolnikov, ki so primerni za zdravljenje z ZIKT, se povečuje tudi število podatkov o varnosti in učinkovitosti ponovne uvedbe ZIKT po nastalem irAE. V prisevku sta povzeti dve nedavni študiji, ki analizirata podatke o ponovni uvedbi ZIKT po razrešenem irAE.
Ključne besede: imunoterapija, onkologija, onkološko zdravljenje
Objavljeno v DiRROS: 16.02.2023; Ogledov: 470; Prenosov: 196
Celotno besedilo (16,12 MB)
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40. Nevrološki zapleti zdravljenja z zaviralci imunskih nadzornih točkNadja Novak, Aljoša Andlovic, Rok Roš Opaškar, 2022, objavljeni znanstveni prispevek na konferenci Povzetek: Pomembnemu ugodnemu učinku zdravljenja z zaviralci imunskih nadzornih točk so relativno pogosto pridruženi neželeni zapleti, med katerimi so nevrološki redki, a lahko življenje ogrožujoči. V prispevku so predstavljeni nevrološki zapleti zdravljenja z zaviralci imunskih nadzornih točk. Podana klinična primera opišeta nevrološka zapleta s klinično sliko prizadetosti perifernega živčevja, in sicer miozitisom in akutno inflamatorno demielinizirajočo polinevropatijo.
Ključne besede: neželeni učinki, bolniki, sistemsko zdravljenje
Objavljeno v DiRROS: 23.01.2023; Ogledov: 373; Prenosov: 97
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