1. New marker of angiogenesis CD105 (endoglin): diagnostic, prognostic and therapeutic roleMateja Legan, 2005, pregledni znanstveni članek Povzetek: Background. The well established notion that malignant tumours depend on angiogenesis to grow and metastasize focused the investigators interest on tumour vasculature into visualization and validation. Panendothelial markers (CD31, CD34, F8) and CD105 are differentially expressed in angiogenic and normal vessel endothelial cells. Since the former are excellent markers for the normal vasculature, CD105 (endoglin) is more suitable for identifying tumour angiogenesis. Endoglin is a transforming growth factor (TGF)- beta binding receptor, preferentially expressed on endothelial cells of angiogenic tissues, essential for angiogenesis and vascular development. Conclusions. Tumor microvessel density expressed by CD105 immunohistochemical staining in paraffin-embedded tissue section correlates significantly with tumour aggressiveness and prognosis in many solid tumours. Also, targeting of tumour neovasculature specific antigens offers the possibility of future therapeutic approaches. Objavljeno v DiRROS: 14.02.2024; Ogledov: 371; Prenosov: 84 Celotno besedilo (96,88 KB) |
2. The role of cyclooxygenase-2 in the malignant tissue and possible applicability of cyclooxygenase-2 inhibitors in the therapy of cancerMateja Legan, 2003, pregledni znanstveni članek Povzetek: Cyclooxygenase-2 (COX 2), an inducible prostaglandin (PG) synthase, is elevated in many types of malignant and pre-malignant tissues. This enzyme is localized in neoplastic (epithelial) cells, microvascular endothelial cells, and stromal fibroblasts. Through the released PG it enhances carcinogenesis with increasing angiogenesis, inhibiting apoptosis, activating matrix metalloproteinases, suppressing of cell mediated antitumor immune response andprotection against damage by cytotoxic agents. Evidences from in vitro studies, studies on animal models as well as first clinical outcomes suggest that the inhibition of COX 2 may suppress carcinogenesis by affecting a numberof pathways: inhibiting angiogenesis, invasiveness of tumors and promoting apoptosis. References forecast that COX 2 inhibitors, mostly COX 2 selective inhibitors, may get a role in the therapy of cancer as an adjuvant therapy or as an co-chemotherapeutic agent. The purpose of the present articleis to summarize the most important facts about the role of COX 2 in themalignant tissue and discuss possible ways for potential therapeutic place of COX 2 inhibitors in clinical practice. Objavljeno v DiRROS: 06.02.2024; Ogledov: 362; Prenosov: 84 Celotno besedilo (205,37 KB) |
3. |
4. Uporaba testov HPV DNK za presejanje za raka materničnega vratuMatejka Rebolj, 2011, strokovni članek Povzetek: Okužba z onkogenimi tipi humanih papilomavirusov (HPV) je potreben pogoj za razvoj raka materničnega vratu. Zaradi dolgoletne uporabe citoloških brisov se je incidenca tega raka zmanjšala, a kljub temu bi bilo treba najti nov presejalni test, ki bi bil občutljivejši za progresivne predrakave spremembe, cervikalno intraepitelialno neoplazijo (CIN). Med te teste spadajo testi HPV DNK. V tem članku so opisane njihove značilnosti, kakor jih je mogoče presoditi na podlagi vseh 8 randomiziranih kontroliranih raziskav z objavljenimi podatki, ki so primerjale uporabo testov HPV s citološkimi brisi za primarno presejanje. Te raziskave so potrdile, da je mogoče na podlagi testov HPV diagnosticirati večje število ≥ CIN 3 kot na podlagi citoloških brisov, čeprav razlika v nekaterih od raziskav, tudi zaradi njihove velikosti, ni bila statistično značilna. Razveseljivo je, da večja občutljivost za ≥ CIN 3 verjetno pomeni tudi boljšo zaščito pred rakom materničnega vratu, čeprav ocena temelji na majhnem številu opazovanih primerov v vsaki izmed raziskav. Pri uporabi testov HPV bo večji izziv omejiti njihove neželene učinke. To so predvsem pogostejši napačno pozitivni testi (ki jih definiramo kot pozitivne presejalne teste brez diagnoze ≥ CIN 3 ali ≥ CIN 2) ter pogostejše diagnoze in morebitno zdravljenje manj nevarnih stopenj CIN (predvsem CIN 1, deloma tudi CIN 2). V tem članku so kritično ovrednoteni 3 pristopi k zmanjšanju bremena testov HPV v primerjavi s citološkimi brisi, in sicer uporaba triažnih testov pri ženskah s pozitivnimi presejalnimi testi HPV, omejitev uporabe testov HPV pri mlajših ženskah in sprememba mejne vrednosti, pri kateri se test HPV odčita kot pozitiven. Vsi ti pristopi imajo svoje prednosti in slabosti. Ključne besede: maternični vrat, rak (medicina), preventivna medicina, papiloma virusi Objavljeno v DiRROS: 31.08.2018; Ogledov: 3390; Prenosov: 881 Celotno besedilo (166,86 KB) |
5. Temeljna načela dobre kmetijske prakse varstva rastlin in varne rabe fitofarmacevtskih sredstevGregor Urek, Mateja Bolčič Tavčar, Renata Fras, Viktor Jejčič, Matejka Per, Jolanda Persolja, Lucija Šarc, Meta Urbančič Zemljič, Metka Žerjav, 2013, strokovna monografija Ključne besede: integrirano varstvo rastlin, bolezni, škodljivci, zaščita rastlin, zakonodaja, naprave, postopki, varstvo okolja, varnost pri delu Objavljeno v DiRROS: 11.07.2017; Ogledov: 5577; Prenosov: 1111 Povezava na celotno besedilo |
6. Amino- and ionic liquid-functionalised nanocrystalline ZnO via silane anchoring - an antimicrobial synergyMarjeta Čepin, Vasko Jovanovski, Matejka Podlogar, Zorica Crnjak Orel, 2015, izvirni znanstveni članek Povzetek: Temperature has critical impact on food quality and
safety within food supply chain, therefore, food should
be kept at the defined storage temperature range.
Final consumer should be assured when buying food
about actual temperature and thermal history of the
selected food product and this is why it should be indicated
on the packed or prepacked item.
The chromogenic temperature indicator for cold food
chain was prepared from suitable active material
packed in the properly structured holder. When temperature
rises above the defined storage temperature,
the active material changes colour and physical state
(solid/liquid). Simultaneously, special packaging structure
enables irreversible recording of the time exposed
to the elevated temperature. The active material was
made of thermochromic composite, consisting of dye,
developer and solvent. It changes colour at its melting
point, being coloured below and discoloured above
it. The temperature is called activation temperature of
the composite. Its value was adjusted by appropriate
solvent and additives used for preparation of the composite,
to reach the desired value. The temperature
dependent colour change of the composite was determined
by colorimetric measurements. The conditions
for best observation of the change by naked eye were
also examined. The structure of the active material’s
holder was analyzed for best displaying of the time
spend at high temperature (above the activation temperature).
Functioning of the indicator was examined with
growth of pathogens as a function of migration of
the active material at temperature above the required
storage temperature of the food. It was found out that
the described chromogenic temperature indicator for
cold food chain shows the thermal history of food storage
by colour-, phase- and migration changes of the
active composite material and consequently would be
reliable as indicator in cold food chain to indicate temperature
abuse and would disclose potential growth of
psychrophilic microorganisms. Ključne besede: Chromogenic temperature indicator, Food
cold chain, Food quality and safety, Temperature control, Thermal history Objavljeno v DiRROS: 16.12.2014; Ogledov: 6485; Prenosov: 1043 Povezava na celotno besedilo |