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51.
Composite landslide in the dynamic alpine conditions: a case study of Urbas landslide
Ela Šegina, Mateja Jemec Auflič, Matija Zupan, Jernej Jež, Tina Peternel, 2022, izvirni znanstveni članek

Povzetek: The alpine environment is characterized by complex geology, high-energy terrain, deeply incised river valleys with high erosional potential, extreme weather conditions and dynamic geomorphic processes. Such settings provide favourable conditions for the formation of composite landslides rather than individual slope mass movement phenomena. As an example, we present the kinematics of the composite landslide Urbas in the North of Slovenia which developed in the complex geological and morphological settings characteristic of the alpine environment. The research combines several monitoring techniques and involves the integration of both surface and subsurface displacements measured in the landslide area. The results indicate that the composite sliding process consists of several simultaneous and interrelated types of movements occurring in different segments of the unstable mass that are governed by different mechanisms of displacements, such as rockfall, sliding and debris flow. The kinematic characteristics of a deep-seated landslide that formed in such conditions vary spatially, but is rather homogenuous vertically, indicating translational type of movement. Spatial kinematic heterogeneity is primarily related to the diverse terrain topography, reflecting in different displacement trends. Based on the revealed kinematic proprieties of the sliding material, the sediment discharge illustrates the sliding material balance which estimates the volume of the retaining material that represents the potential for slope mass movement events of larger scales.
Ključne besede: composite landslide, alpine conditions, kinematics, monitoring, sediment discharge
Objavljeno v DiRROS: 15.12.2022; Ogledov: 630; Prenosov: 176
.pdf Celotno besedilo (8,00 MB)

52.
What about the family? : the role and meaning of family in the integration of migrant children
Zorana Medarić, Barbara Gornik, Mateja Sedmak, 2022, izvirni znanstveni članek

Povzetek: Based on field research in Slovenian schools, the article examines the role of the family in the integration process of migrant children. While migrant children perceive the family as the most important factor influencing their overall well-being and life satisfaction, research shows that parents of migrant children are often not involved in school activities and life. The article explores how the role of parents in the integration process of migrant children in the school environment is understood at the policy level and how it is perceived by migrant children and the educational community. It also explores what are the main barriers to the involvement of migrant parents in schools and what are the existing practices and experiences in Slovenian schools. The analysis is based on qualitative research in Slovenian schools with children and the educational community conducted as part of the Migrant Children and Communities in a Transforming Europe (MiCREATE) project.
Ključne besede: migration, migrant children, integration, child-centered approach, family, school
Objavljeno v DiRROS: 13.12.2022; Ogledov: 478; Prenosov: 299
.pdf Celotno besedilo (446,31 KB)
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53.
Programske smernice DORA
Mateja Kurir-Borovčić, Amela Duratović Konjević, Katja Jarm, Katarina Nagode, Maksimiljan Kadivec, Zvonka Kastelic, Veronika Kutnar, Andraž Perhavec, Barbara Skubic-Vengušt, Stanka Sabo, Špela Sitar, Stančka Suljić, Cveto Šval, Anastazija Šelih, Vesna Škrbec, Miloš Vrhovec, Sonja Tomšič, Katarina Torkar, Urban Zdešar, Kristijana Hertl, 2022, strokovna monografija

Povzetek: Državni presejalni program za raka dojk DORA (v nadaljevanju: program DORA) vabi ženske med 50. in 69. letom vsaki dve leti na presejanje z mamografijo, katerega cilj je zmanjšati umrljivost za rakom dojk v ciljni populaciji za 25 do 30 odstotkov. Nosilec programa DORA je Onkološki inštitut Ljubljana. Presejalno mamografijo opravlja 16 javnih zdravstvenih zavodov po Sloveniji na 20 digitalnih mamografih s kadri, ki so za svoje delo posebej usposobljeni. Dodatno diagnostiko in zdravljenje raka dojk, odkritega v presejanju, izvajata presejalno-diagnostična centra na Onkološkem inštitutu Ljubljana in v Univerzitetnem kliničnem centru Maribor. Te programske smernice opredeljujejo presejalno politiko programa DORA, postopek obravnave žensk, organizacijo in dejavnosti programa DORA. Delijo se na upravljalske, zdravstvene in druge storitve. Sestavni del teh programskih smernic je tudi določitev strokovnega nadzora, ki se opravlja v presejalnem programu, ter podrobnejši Standardni operativni postopki (SOP) delovanja programa DORA. Sestavni del tega dokumenta so tudi Protokoli in priloge.
Ključne besede: rak dojke, programske smernice, presejalni programi, svetovanje
Objavljeno v DiRROS: 08.12.2022; Ogledov: 616; Prenosov: 265
.pdf Celotno besedilo (328,03 KB)
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54.
Celostna rehabilitacija onkoloških bolnikov
Lorna Zadravec-Zaletel, Mateja Kurir-Borovčić, Nikola Bešić, 2022, strokovni članek

Povzetek: V okviru Državnega programa obvladovanja raka (DPOR) smo z aktivnostmi za vzpostavitev celostne rehabilitacije onkoloških bolnikov pričeli leta 2017. Celostna rehabilitacija zajema medicinsko, psihološko, socialno in poklicno rehabilitacijo ter je prilagojena posameznemu bolniku. Omogoča zgodnje prepoznavanje somatskih in psihičnih posledic malignega obolenja in njegovega zdravljenja ter njihovo čim prejšnje odpravljanje. Njena dobrobit je boljša kakovost življenja bolnikov od postavitve diagnoze dalje ter hitrejša vrnitev na delovno mesto. Raziskava celostne rehabilitacije bolnic z rakom dojk OREH se na Onkološkem inštitutu (OI) Ljubljana izvaja od leta 2019 in je namenjena razvoju ter testiranju novega sistema celostne rehabilitacije za onkološke bolnike v Sloveniji. Osrednja oseba v celostni rehabilitaciji je koordinatorka celostne rehabilitacije (diplomirana medicinska sestra) za onkološke bolnike, ki z vprašalniki preverja, s katerimi težavami se bolnica sooča, in je bolnici v oporo med težkimi preizkušnjami na poti zdravljenja. Prek multidisciplinarnega konzilija OREH je bolnica v odvisnosti od izraženosti težav in v skladu s smernicami ter klinično potjo celostne rehabilitacije napotena na različne storitve celostne rehabilitacije v okviru mreže izvajalcev. Preliminarne analize rezultatov kažejo dobrobit celostne rehabilitacije na določenih področjih. V okviru celostne rehabilitacije vzpostavljamo tudi klinični register poznih posledic zdravljenja raka v otroštvu, v mesecu oktobru pa bomo začeli na OI Ljubljana izvajati Pilotno raziskavo celostne rehabilitacije bolnikov z rakom debelega črevesja in danke 2022– 2024. Naš namen je namreč razširiti celostno rehabilitacijo na širši krog onkoloških bolnikov, kar je zapisano tudi v zavezujočem dokumentu DPOR 2022–2026. V prihodnosti bomo razširili in izboljšali sodelovanje s sodelujočimi institucijami, zagotovili financiranje dejavnosti celostne rehabilitacije in si prizadevali spremeniti zakonodajo zgodnje poklicne rehabilitacije. Oviro za hitrejšo implementacijo celostne rehabilitacije predstavlja predvsem pomanjkanje ustreznih strokovnjakov in prostorov.
Ključne besede: celostna rehabilitacija, onkološki bolniki, Državni program obvladovanja raka, rak dojke
Objavljeno v DiRROS: 06.12.2022; Ogledov: 529; Prenosov: 137
.pdf Celotno besedilo (105,71 KB)

55.
56.
Solid carriers of potentially toxic elements and their fate in stream sediments in the area affected by iron ore mining and processing
Saša Kos, Nina Zupančič, Mateja Gosar, Miloš Miler, 2022, izvirni znanstveni članek

Povzetek: The potential environmental impact of historical mining and ore processing on stream sediments and water was studied in a small siderite iron ore deposit with diverse sulfide mineral paragenesis. The main aim was to characterize solid carriers of potentially toxic elements (PTEs) in stream sediments and mine waste, to understand their fate in fluvial systems. General mineralogy (X-ray powder diffraction) and individual solid PTE carriers (scanning electron microscopy/energy dispersive spectroscopy) were correlated with the geochemical composition of stream sediments, mine waste, and stream waters (inductively coupled plasma mass spectrometry). Primary solid PTE carriers were pyrite, chalcopyrite, sphalerite, Hg-bearing sphalerite, galena, and siderite. Slightly alkaline and oxidizing conditions in stream water promoted the transformation of primary phases into secondary PTE carriers. Fe(Mn)-oxide/oxyhydroxides were major sinks for Pb, Zn, and As. Compared to background levels, Co (14.6 ± 2.1 mg/kg), Cu (30 ± 2.9 mg/kg), Ni (32.1 ± 2.9 mg/kg), Pb (64.5 ± 16.4 mg/kg), Zn (175.3 ± 22.5 mg/kg), As (81.1 ± 63.7 mg/kg), and Hg (2 ± 0.8 mg/kg) were elevated in mining area. Mine waste contained similar PTE carriers as stream sediments, but much higher PTE contents. Prevailingly low PTE concentrations in streams, with the exception of As (1.97 ± 2.4 µg/L) and Zn (4.5 ± 5.7 µg/L), indicate the stability of PTE carriers. Environmental effects were not significant, and additional monitoring is recommended.
Ključne besede: environmental mineralogy, environmental geochemistry, potentially toxic elements, stream sediments, solid phases, iron ore deposit, SEM/EDS
Objavljeno v DiRROS: 16.11.2022; Ogledov: 538; Prenosov: 175
.pdf Celotno besedilo (8,07 MB)

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58.
Review of the research and evolution of landslides in the hinterland of Koroška Bela settlement (NW Slovenia)
Tina Peternel, Ela Šegina, Jernej Jež, Mateja Jemec Auflič, Mitja Janža, Janko Logar, Matjaž Mikoš, Miloš Bavec, 2022, izvirni znanstveni članek

Povzetek: This paper gives an overview of landslide research and the activity of landslides located above the Koroška Bela settlement in Northwest Slovenia. There are several landslides in this area and they pose a direct threat to the settlement below. The settlement is very densely populated (about 2,100 inhabitants) and has well-developed industry and infrastructure. It is built on deposits from past debris flows, indicating that large slope mass movements have occurred in the past. In this regard, the hinterland of Koroška Bela has been investigated since 2006, within the framework of various research, technical and European projects. The most extensive geological and geotechnical investigations were carried out after April 2017, when part of the Čikla landslide collapsed and mobilised into a debris flow. All of the investigations which have been carried out over the years revealed that the hinterland of Koroška Bela is characterised by high landslide activity due to geological, hydrogeological and tectonic conditions. In order to protect people and their property, it is essential to implement a holistic mitigation measure which includes remediation works (drainage works, debris flow breaker, etc.) and non-structural measures (monitoring system, early warning system, risk management, etc.). Regular and continuous monitoring of all landslides is also crucial to observe the landslide dynamics and evaluate the effectiveness of structural mitigation measures.
Ključne besede: landslide, debris flow, research, monitoring, landslide evolution, Koroška Bela
Objavljeno v DiRROS: 03.10.2022; Ogledov: 660; Prenosov: 186
.pdf Celotno besedilo (11,09 MB)

59.
Medullary thyroid carcinoma and associated endocrinopathies in Slovenia from 1995 to 2021
Sara Milićević, Mateja Krajc, Ana Blatnik, Barbara Perić, 2022, izvirni znanstveni članek

Povzetek: Background: Medullary thyroid cancer (MTC) is a rare endocrine tumour that is sporadic in 75% of cases and occurs as a part of inherited cancer syndromes in approximately 25% of cases. The aim of this study was to determine the frequency and type of RET pathogenic variants (PVs) in the Slovenian MTC patient population diagnosed between 1995 and 2021 and to elucidate the full range of associated endocrinopathies. Methods: A retrospective analysis of medical records of 266 MTC patients and their relatives seen in a tertiary centre between 1995 and 2021 was performed. Sequence analysis of exons 10, 11, 13, 14, 15, and 16 of the RET gene was analysed in most patients using Sanger sequencing. From 2017, the entire sequence of RET gene was analysed in most patients using targeted next-generation sequencing. Results: Germline PVs in the RET proto-oncogene were identified in 21.6% probands from 21 different MTC families. Of their tested relatives, 65% (67/103) were RET-positive and 35% (36/103) were RET-negative. PVs were detected in codon 618 and codon 634 in 28.6%, and in codon 790 in 23.8%. The RET-positive group consisted of 52 MTC patients, 13 patients with C cell hyperplasia and 2 individuals with neither. Associated endocrinopathies were diagnosed in 8/21 families: primary hyperparathyroidism (PHPT) in six families and pheochromocytoma (PHEO) in five families. In 62% of RET-positive families (13/21), no associated endocrinopathies were diagnosed. PHEO was most commonly associated with C634R (6/13) and PHPT with C634R (4/7). Hirschsprung’s disease appeared in one patient with RET PV in codon 618. Based on data from the Cancer Registry of Republic of Slovenia, only individual cases of common cancers with well understood environmental risk factors were discovered; lung cancer in 2/21 of families, papillary thyroid cancer in 3/21 of families, cutaneous melanoma in 2/21 of families, cervical cancer in 1/21 families, and lymphoma in 1/21 families. Conclusions: Analysis of prospectively collected MTC cases during a 27-year period revealed that 21.6% of Slovenian patients are RET PV carriers. Sixty-two percent of families had none of the associated endocrinopathies, confirming the thesis that FMTC is the most common presentation. This could suggest using risk-stratified management approaches when screening for PHEO and PHPT in RET PV carriers. However, more studies are needed to evaluate potential genetic risk modifiers as well as safety, improved quality of life, and medical cost reduction in the case of a patient-oriented approach.
Ključne besede: medullary thyroid carcinoma, multiple endocrine neoplasia, primary hyperparathyroidism
Objavljeno v DiRROS: 23.09.2022; Ogledov: 538; Prenosov: 252
.pdf Celotno besedilo (248,03 KB)
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60.
Trends and timing of risk-reducing mastectomy uptake in unaffected BRCA1 and BRCA2 carriers in Slovenia
Taja Ložar, Janez Žgajnar, Andraž Perhavec, Ana Blatnik, Srdjan Novaković, Mateja Krajc, 2021, izvirni znanstveni članek

Povzetek: Objectives. Risk-reducing mastectomy (RRM) is one of key prevention strategies in female carriers of germline BRCA pathogenic/likely pathogenic variants (PV/LPV). We retrospectively investigated the rate, timing and longitudinal trends of bilateral RRM uptake and the incidence and types of cancers among unaffected BRCA carriers who underwent genetic counseling at the Institute of Oncology Ljubljana in Slovenia. Materials and Methods. Female BRCA carriers without personal history of cancer were included in the study. Clinical data on PV/LPV type, date of RRM, type of reconstructive procedure, occult carcinoma and histopathology results was collected and analyzed. Results. Of the 346 unaffected BRCA carriers (median age 43 years, 70% BRCA1, 30% BRCA2, median follow-up 46 months) who underwent genetic testing between October 1999 and December 2019, 25.1% had a RRM (range 35-50 years, median age at surgery 38 years). A significant difference in time to prophylactic surgery between women undergoing RRM only vs. women undergoing RRM combined with risk-reducing salpingo-oophorectomy was observed (22.6 vs 8.7 months, p=0.0009). We observed an upward trend in the annual uptake in line with the previously observed Angelina Jolie effect. In 5.7% of cases, occult breast cancer was detected. No women developed breast cancer after RRM. Women who did not opt for surgical prevention developed BRCA1/2-related cancers (9.3%). Conclusion. The uptake of RRM among unaffected BRCA carriers is 25.1% and is similar to our neighboring countries. No women developed breast cancer after RRM while women who did not opt for surgical prevention developed BRCA1/2 related cancers in 9.3% of cases. The reported data may provide meaningful aid for carriers when deciding on an optimal prevention strategy.
Ključne besede: risk-reducing mastectomy, breast cancer, BRCA
Objavljeno v DiRROS: 21.09.2022; Ogledov: 444; Prenosov: 150
.pdf Celotno besedilo (593,94 KB)

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