61. Odpornost glioblastoma na radioterapijo : vpliv rakavih matičnih celic in mikroo[ko]lja tumorjaBarbara Breznik, Bernarda Majc, Anamarija Habič, Urška Ušeničnik, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Marija Skoblar Vidmar, Tanja Jesenko, Maja Čemažar, Tamara Lah Turnšek, Metka Novak, 2022, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje) Povzetek: Glioblastom je najpogostejši možganski tumor pri odraslih z zelo slabo prognozo preživetja bolnikov. Ta je posledica odpornosti glioblastoma na standardno zdravljenje, ki vključuje radioterapijo in kemoterapijo. Z namenom načrtovanja učinkovitejših pristopov zdravljenja preučujemo biološke mehanizme odpornosti glioblastoma na radioterapijo s poudarkom na mikrookolju tumorja in rakavih matičnih celicah. V predkliničnih raziskavah uporabljamo napredne in personalizirane celične modele, ki posnemajo mikrookolje tumorja v bolnikih in z večjo natančnostjo napovedo odziv bolnika na zdravljenje. Hkrati so takšni modeli pomembni za testiranje novih pristopov za zdravljenje kot je imunoterapija.
Ključne besede: glioblastom, mikrookolje, organoidi, možganski rak, možganski tumor, onkologija
Objavljeno v DiRROS: 16.06.2022; Ogledov: 621; Prenosov: 199
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62. Insight into the interdependence of Ni and Al in bifunctional Ni/ZSM-5 catalysts at the nanoscaleHue-Tong Vu, Iztok Arčon, Danilo Oliveira de Souza, Simone Pollastri, Goran Dražić, Janez Volavšek, Gregor Mali, Nataša Zabukovec Logar, Nataša Novak Tušar, 2022, izvirni znanstveni članek Ključne besede: Ni/ZSM-5 catalysts, zeolite, Ni XANES, EXAFS
Objavljeno v DiRROS: 13.06.2022; Ogledov: 831; Prenosov: 415
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63. Geographical and temporal diversity of ‘Candidatus Phytoplasma solani' in wine-growing regions in Slovenia and AustriaNataša Mehle, Sanda Kavčič, Sara Mermal, Sara Vidmar, Maruša Pompe Novak, Monika Riedle-Bauer, Günter Brader, Aleš Kladnik, Marina Dermastia, 2022, izvirni znanstveni članek Povzetek: As the causal agent of the grapevine yellows disease Bois noir, ‘Candidatus Phytoplasma solani’ has a major economic impact on grapevines. To improve the control of Bois noir, it is critical to understand the very complex epidemiological cycles that involve the multiple “Ca. P. solani” host plants and insect vectors, of which Hyalesthes obsoletus is the most important. In the present study, multiple genotyping of the tuf, secY, stamp, and vmp1 genes was performed. This involved archived grapevine samples that were collected during an official survey of grapevine yellows throughout the wine-growing regions of Slovenia (from 2003 to 2016), plus samples from Austrian grapevines, stinging nettle, field bindweed, and insect samples (collected from 2012 to 2019). The data show that the tuf-b2 type of the tuf gene has been present in eastern Slovenia since at least 2003. The hypotheses that the occurrence of the haplotypes varies due to the geographical position of Slovenia on the Italian–Slovenian Karst divide and that the haplotypes are similar between Slovenian and Austrian Styria were confirmed. The data also show haplotype changes for host plants and H. obsoletus associated with ‘Ca. P. solani,’ which might be linked to new epidemiological cycles of this phytoplasma that involve not just new plant sources and new insect vectors, but also climate and land-use changes.
Ključne besede: Bois noir, genotyping, ‘Ca. P. solani’, tuf gene, secY, survey, tuf-b2, stamp
Objavljeno v DiRROS: 10.06.2022; Ogledov: 833; Prenosov: 527
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68. New data on lower Permian rugose corals from the Southern Karavanke Mountains (Slovenia)Olga L. Kossovaya, Matevž Novak, Dieter Weyer, izvirni znanstveni članek Povzetek: Studies of upper Palaeozoic corals from the Southern Alps (Karavanke Mountains in Slovenia and Carnic Alps along the Austrian/Italian border) started at the end of the 19th century. Since the mid-20th century, corals of the Karavanke Mountains have been studied in detail by several authors. Recently, several coral type localities and the coral groups occurring therein have been einvestigated. This paper deals in particular with the study of Carinthiaphyllum Heritsch, 1936 and all previously known data have been revised within this study. Most specimens of Carinthiaphyllum originate from museum collections and from new findings in the Dovžanova Soteska area of northern Slovenia. Additional material is represented by newly found samples from the locality of Mt. Boč in eastern Slovenia. The stratigraphic position and age of the Carinthiaphyllum occurrences are determined by fusulinid and conodont assemblages. Two species, Carinthiaphyllum crasseseptatum Gräf & Ramovš, 1965 and C. ramovsi n. sp., are described herein. New morphological features, including root-like protrusions and connecting stereoplasmic tubes, have been found for the first time in gregaria growth mode. Therefore, these new observations provide evidence of a solitary gregaria growth mode: individuals are invariably separated with contact and reciprocal support only by root-like, sometimes channeled tubes occurring as outgrowths of the archaeothecal wall. An emended diagnosis of Carinthiaphyllum is proposed herein. The studied collection is housed in the Museum für Naturkunde (Leibniz-Institut) at the Humboldt University in Berlin.
Ključne besede: Gregaria corals, Carinthiaphyllum, Asselian-Sakmarian, Southern Alps
Objavljeno v DiRROS: 04.03.2022; Ogledov: 638; Prenosov: 232
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69. Zdrava izbira - organizirana presejanja za raka v SlovenijiKatja Jarm, Dominika Novak-Mlakar, Urška Ivanuš, Tatjana Kofol-Bric, Ana Šinkovec, Mojca Florjančič, Kaja Batista, 2021, objavljeni strokovni prispevek na konferenci Ključne besede: presejalni programi, preventivni programi, onkologija, javno zdravje
Objavljeno v DiRROS: 17.12.2021; Ogledov: 822; Prenosov: 282
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70. Analiza trenda napotitev na onkološko genetsko obravnavo pri bolnicah z rakom jajčnikov, ki potrebujejo genetski izvid za načrtovanje zdravljenja in predstavitev novih kliničnih poti obravnaveSvetlana Novak, Simona Hotujec, Ksenija Strojnik, Ana Blatnik, Erik Škof, Maja Ravnik-Oblak, Srdjan Novaković, Mateja Krajc, 2021, izvirni znanstveni članek Povzetek: Zadnjih nekaj let se v genetskih ambulantah soočamo s pogostejšimi napotitvami bolnikov z rakom na genetsko obravnavo. Izvid genetskega testiranja je namreč pri bolnicah z epitelijskim nemucinoznim rakom jajčnikov/jajcevodov/primarnim peritonealnim seroznim karcinomom (PPSC) in bolnikih z metastatskim rakom prostate/pankreasa/dojk lahko zelo pomemben za načrtovanje zdravljenja z zaviralci poli(ADP-riboza)-polimeraze (PARP). Ker se z obravnavo običajno mudi, smo izdelali dve klinični poti, ki omogočita tem bolnikom prednostno obravnavo.
Ključne besede: epitelijski nemucinozni rak jajčnikov, epitelijski nemucinozni rak jajcevodov, primarni peritonealni serozni karcinom/PPSC, prednostna napotitev, genetsko testiranje, BRCA1/2
Objavljeno v DiRROS: 13.12.2021; Ogledov: 952; Prenosov: 416
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