1. Treatment-related cardiovascular toxicity in long-term survivors of testicular cancerJasenka Gugić Kevo, Lorna Zadravec-Zaletel, Irena Oblak, 2017, pregledni znanstveni članek Povzetek: Testicular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life expectancy, assessment of long term toxicity in testicular cancer survivors is of great importance. In the last decades a major effort has been made in order to reduce toxicity of treatment, while maintaining its high effectiveness. Conclusions Actual knowledge on treatment toxicity is based on outdated treatment modalities. Hopefully, modern treatment modalities could reduce toxicity, but, there is no firm confirmation for that at the moment, as data dealing with late sequelae of modern treatment of testicular cancer are not available yet due to the short period of observation. The life-threatening cardiovascular toxicity in testicular cancer survivors is major complication of platinum-based chemotherapy, mediastinal radiotherapy and even subdiaphragmatic radiotherapy.
Ključne besede: testicular cancer, cardiovascular toxicity, long-term survivors
Objavljeno v DiRROS: 24.05.2024; Ogledov: 76; Prenosov: 32
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2. Immunotoxin - a new treatment option in patients with relapsed and refractory Hodgkin lymphomaBarbara Jezeršek Novaković, 2015, pregledni znanstveni članek Povzetek: Background. Even though Hodgkin lymphoma is a highly curable disease, some of the patients have either a refractory disease or experience a relapse following a successful primary therapy. Durable responses and remissions in patients with relapsed or refractory disease may be achieved in approximately one-half with salvage chemotherapy followed by high dose chemotherapy (HDT) and autologous hematopoietic cell rescue (SCT). On the other hand, patients who relapse after HDT and autologous SCT or those who have failed at least two prior multi-agent chemotherapy regimens and are not candidates for HDT have limited treatment options. Conclusions. A new treatment option in this population is an immunotoxin Brentuximab vedotin composed of a CD30 directed antibody linked to the antitubulin agent monomethyl auristatin E. It has demonstrated a substantial effectiveness and an acceptable toxicity. In the pivotal study, the overall response rate was 75% with 34% of complete remissions. The median durations of response were 20.5 and 6.7 months for those with complete remission and all responding patients, respectively. The median overall survival was 40.5 months (3-years overall survival 54%) and the median progression-free survival 9.3 months. The most common non-hematologic toxicities were peripheral sensory neuropathy, nausea, and fatigue while the most common severe side effects were neutropenia, thrombocytopenia, anemia, and peripheral sensory neuropathy.
Ključne besede: immunotoxin, Hodgkin lymphoma, toxicity, new treatment option
Objavljeno v DiRROS: 22.04.2024; Ogledov: 381; Prenosov: 387
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3. Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in SloveniaAna Jeromen, Irena Oblak, Franc Anderluh, Vaneja Velenik, Marija Skoblar Vidmar, Ivica Ratoša, 2012, izvirni znanstveni članek Ključne besede: gastroesophageal junction adenocarcinoma, postoperative radiochemotherapy, toxicity
Objavljeno v DiRROS: 21.03.2024; Ogledov: 157; Prenosov: 40
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4. Degradation and Stabilization of Polymer MaterialsBranka Mušič, Andrijana Sever Škapin, 2023, drugi znanstveni članki Ključne besede: polymer-based materials, nano, micro, and macro composites, effects on (micro) organisms and toxicity, impact on the ecosystem, mechanisms and products of accelerated aging and degradation, physical, chemical, mechanical, thermal, and morphological, analysis, biodegradability, sustainability, life cycle, renewable and recycled resources and the circular economy
Objavljeno v DiRROS: 21.12.2023; Ogledov: 303; Prenosov: 106
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5. Stability and toxicity of selected chlorinated benzophenone-type UV filters in watersRomina Žabar, Darko Dolenc, Polonca Trebše, Tatjana Tišler, Gorica Grbović, Jun Yao, Rensheng Zhuang, 2013, izvirni znanstveni članek Povzetek: Stability and toxicity of selected chlorinated benzophenone-type UV filters in waters
Ključne besede: UV filter, photostability, chlorination, toxicity, Vibrio fischeri
Objavljeno v DiRROS: 16.03.2016; Ogledov: 3900; Prenosov: 512
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