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3. Onkologija : strokovni časopis za zdravnike1997 Opis: Dvojno slepo recenzirana revija, ki izhaja dvakrat letno, je bila ustanovljena leta 1997. Revija Onkologija je odprtodostopna revija in izhaja v skladu s pogoji licence Creative Commons Attribution CC-BY 4.0.
Revija objavlja izvirne in pregledne strokovno-znanstvene članke, predstavitve kliničnih primerov, poročila in klinične smernice v slovenskem jeziku. Naslovi, povzetki in ključne besede prispevkov so prevedeni v angleščino.
Namenjena je hitremu pretoku znanja v vsakdanjo onkološko prakso. Kot multidisciplinaren časopis teoretično in praktično obravnava različna področja onkologije, zlasti primarno in sekundarno preventivo malignih tumorjev, njihovo zgodnje odkrivanje ter zdravljenje, rehabilitacijo in paliacijo pri onkoloških bolnikih, pa tudi socialne in etične probleme.
S strokovno pregledanimi prispevki revija ozavešča klinične zdravnike in jih seznanja z najnovejšimi informacijami in glavnimi smernicami razvoja njihove stroke. Tako omogoča globlje razumevanje in boljšo prakso na ravni vsakodnevnega strokovnega zdravniškega dela. Z izdajo člankov v slovenskem jeziku ima revija ključno vlogo pri razvoju in bogatitvi slovenske medicinske terminologije.
Ključne besede: onkologija, novotvorbe, radiologija, paliativna medicina, terapija z zdravili, metastaze, onkološka epidemiologija
Objavljeno: 14.03.2018; Ogledov: 20222; Prenosov: 1255
 Povezava na datoteko
Ogledov v tednu: 94 |
4. First Report of Globisporangium (Pythium) mastophorum causing Damping-off / Root Rot on Parsley in SloveniaJanja Zajc, Eva Kovačec, Urša Prislan, Aleksandra Podboj Ronta, Metka Žerjav, Hans-Josef Schroers, 2024 Ključne besede: damping-off / Root Rot, parsley, pathogen detection, common bean, phatoggenecity
Objavljeno: 23.10.2024; Ogledov: 288; Prenosov: 52
 Celotno besedilo (225,51 KB)
Ogledov v tednu: 89 |
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7. Initial glutathione depletion during short-term bed restFilippo Giorgio Di Girolamo, Filippo Mearelli, Mariella Sturma, Nicola Fiotti, Kaja Teraž, Alja Ivetac, Alessio Nunnari, Pierandrea Vinci, Boštjan Šimunič, Rado Pišot, Gianni Biolo, 2024 Opis: Hypokinesia triggers oxidative stress and accelerates the turnover of the glutathione system via the γ-glutamyl cycle. Our study aimed to identify the regulatory checkpoints controlling intracellular glutathione levels. We measured the intermediate substrates of the γ-glutamyl cycle in erythrocytes from 19 healthy young male volunteers before and during a 10-day experimental bed rest. Additionally, we tracked changes in glutathione levels and specific metabolite ratios up to 21 days of bed rest. Using gas chromatography-mass spectrometry and the internal standard technique, we observed a 9 ± 9% decrease in glutathione levels during the first 5 days of bed rest, followed by an 11 ± 9% increase from the 5th to the 10th day, nearly returning to baseline ambulatory levels. The cysteinyl-glycine-to-glutathione ratio, reflecting γ-glutamyl cyclotransferase activity (a key enzyme in glutathione breakdown), rose by 14 ± 22% in the first 5 days and then fell by 10 ± 14% over the subsequent 5 days, again approaching baseline levels. Additionally, the γ-glutamyl cysteine-to-cysteine ratio, indicative of γ-glutamyl cysteine synthetase activity (crucial for glutathione synthesis), increased by 12 ± 30% on day 5 and by 29 ± 41% on day 10 of bed rest. The results observed on day 21 of bed rest confirm those seen on day 10. By calculating the ratio of product concentration to precursor concentration, we assessed the efficiency of these key enzymes in glutathione turnover. These results were corroborated by directly measuring glutathione synthesis and degradation rates in vivo using stable isotope techniques. Our findings reveal significant changes in glutathione kinetics during the initial days of bed rest and identify potential therapeutic targets for maintaining glutathione levels.
Ključne besede: antioxidant, muscle unloading, glutathion turnover, γ-glutamyl cycle, gamma-glutamyl cycle
Objavljeno: 21.11.2024; Ogledov: 107; Prenosov: 1098
Celotno besedilo (1,84 MB)
Ogledov v tednu: 70 |
8. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned mediumDarja Marolt Presen, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra-Larissa Stetco, Anja Tanšek, Laura Poženel, Bella Bruszel, Goran Mitulović, Johannes Oesterreicher, Johannes Zipperle, 2024 Objavljeno: 22.11.2024; Ogledov: 118; Prenosov: 925
Celotno besedilo (6,41 MB)
Ogledov v tednu: 69 |
9. Vibrational noise disrupts Nezara viridula communication, irrespective of spectral overlapRok Janža, Nataša Stritih Peljhan, Aleš Škorjanc, Jernej Polajnar, Meta Virant-Doberlet, 2024 Opis: Insects rely on substrate vibrations in numerous intra- and interspecific interactions. Yet, our knowledge of noise impact in this modality lags behind that in audition, limiting our understanding of how anthropogenic noise affects insect communities. Auditory research has linked impaired signal perception in noise (i.e., masking) to spectral overlap. We investigated the impact of noise with different spectral compositions on the vibrational communication of the stink bug Nezara viridula, examining courtship behaviour and signal representation by sensory neurons. We found negative effects of vibrational noise regardless of spectral overlap, challenging common expectations. Noise impaired the ability of males to recognize the female signal and localise its source: overlapping noise decreased sensitivity of receptor neurons to the signal and disrupted signal frequency encoding by phase-locking units, while non-overlapping noise only affected frequency encoding. Modelling neuronal spike triggering in sensory neurons linked disrupted frequency encoding to interference-induced alterations of the signal waveform. These alterations also affected time delays between signal arrivals to different legs, crucial for localisation. Our study thus unveils a new masking mechanism, potentially unique to insect vibrosensory systems. The findings highlight the higher vulnerability of vibration-mediated behaviour to noise, with implications for insect interactions in natural and anthropogenically altered environments.
Ključne besede: biotremology, vibrations, noise, communication, neurons, masking, entomology, neurobiology
Objavljeno: 21.11.2024; Ogledov: 118; Prenosov: 2467
Celotno besedilo (2,25 MB)
Ogledov v tednu: 69 |
10. Estimating the effective char depth in structural timber elements exposed to natural fires, considering the heating and cooling phaseAndrea Lucherini, Daniela Šejnová Pitelková, Vladimír Mózer, 2025 Opis: This research study investigates the effect of different heating and cooling regimes on the effective cross-section of timber elements exposed to natural fires. An advanced calculation method based on a 1D finite-difference heat transfer model and effective thermo-physical properties is adopted to analyse the heat penetration and the consequent reduction in mechanical properties. In particular, the research focuses on the evolution and penetration speed of the char depth (300 ◦C isotherm) and zero-strength layer (determined through in-depth temperatures and reduced mechanical properties). Results reveal how the char depth mainly develops during the heating phase, with non-negligible contributions from the cooling phase. In contrast, the zero-strength layer increases throughout the whole fire exposure, particularly during cooling and, possibly, after the end of the cooling phase. In general, the heating phase contributes about 2/3 to the total effective char depth, while the cooling phase about 1/3. The most challenging conditions were found for the fires of the longest durations (heating and overall), corresponding to low ventilation and high fuel load density conditions. The study emphasises the necessity of incorporating the cooling phase in performance-based methodologies for fire-safe timber structures to avoid under-estimating heat penetration effects.
Ključne besede: timber structures, fire safety, charring, zero-strength layer, natural fire, heating, cooling, structural fire engineering, performance-based design
Objavljeno: 22.11.2024; Ogledov: 108; Prenosov: 424
Celotno besedilo (6,39 MB)
Ogledov v tednu: 66 |