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Title:Germinalni tumorji. Sodobno zdravljenje bolnikov z rakom mod
Authors:ID Škrbinc, Breda (Author)
Files:.pdf PDF - Presentation file, download (172,78 KB)
MD5: 285A75997E2EA57AB0C31669BFD0F397
PID: 20.500.12556/dirros/b950c8e7-cbd0-458f-820c-5bcecdb062a7
 
Language:Slovenian
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Abstract:Germinalni tumorji (tumorji mod) spadajo med redke vrste raka, med mlajšimi moškimi, starimi od 20 do 40 let, pa je to najpogostejša vrsta raka. Če diagnostiko in zdravljenje bolnikov z germinalnim tumorjem vodijo strokovnjaki z izkušnjami na tem področju, je bolezen dobro ozdravljiva tudi v napredovali, metastatski fazi. Zdravljenje lokalno omejene bolezni (klinični stadij I) je konzervativno. Po orhidektomiji, ki je nujen diagnostično-terapevtski poseg, bolnike večinoma sledimo s pogostimi rednimi kontrolnimi pregledi, s katerimi aktivno iščemo morebitno metastatsko bolezen, pooperativno dopolnilno zdravljenje s kemoterapijo (KT) ali obsevanjem (RT) ali retroperitonealno limfadenektomijo (RPLND) pa uvedemo le redkim bolnikom. Bolnike, pri katerih ob kontrolnih pregledih ugotovimo metastatsko bolezen (kamor v klinični praksi štejemo tudi lokoregionalno razširjeno bolezen z zasevki v retroperitonealnih bezgavkah), zdravimo po standardnih načelih zdravljenja bolnikov z metastatskim germinalnim tumorjem. Zdravljenje bolnikov z metastatsko boleznijo načrtujemo s pomočjo napovednih dejavnikov poteka bolezni – histološkega tipa primarnega tumorja (seminomi/ neseminomski germinalni tumorji (NSGCT)), kliničnega stadija bolezni ter serumskih vrednosti tumorskih označevalcev bolezni α-fetoproteina (AFP), β-horiogonadotropina (ß-HCG) in encima laktatdehidrogenaze (LDH). Zdravljenje bolnikov z metastatskim germinalnim tumorjem praviloma začnemo s kombinirano KT, s katero pri bolnikih z manjšim obsegom metastatske bolezni lahko dosežemo ozdravitev, pri bolnikih z obsežnejšim metastatskim NSGCT pa zdravljenje navadno nadaljujemo operativno z odstranitvijo vseh zaostalih zasevkov.
Publication status:Published
Publication version:Version of Record
Year of publishing:2009
Number of pages:str. 114-116, 152
Numbering:Letn. 13, št. 2
PID:20.500.12556/DiRROS-9102 New window
UDC:616.64/.68-006.6
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-LA85OWS0
COBISS.SI-ID:848251 New window
Copyright:by Authors
Publication date in DiRROS:31.08.2018
Views:6207
Downloads:929
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Germ-Cell Tumors: New Improved Treatment Method of Testicular Cancer Patients
Abstract:Germ cell tumors (testicular cancer), though a rare cancer type in general, are one of the most common cancers of young adult men aged between 20 and 40 years. Treatment of germ cell cancer is potentially successful, even in metastatic settings, if the diagnosis and treatment are performed by experienced professionals. The treatment of localized disease is conservative. After orchidectomy which is the initial therapeutical as well as a diagnostic procedure, the patients are thoroughly followed by watchful waiting. Adjuvant treatment in the form of adjuvant chemotherapy, radiotherapy or selective retroperitoneal lymphadenectomy is performed under specific circumstances. Patients who during watchful waiting develop metastatic disease (in clinical practice also metastases in regional lymph nodes are considered as a metastatic disease) are classically treated according to prognostic factors which consist of histological type (seminoma vs. nonseminomal germ cell tumors) of tumor, clinical stage of the disease and the level of serum tumor markers α-fetoprotein (AFP), β-choriogonadotropin (β-HCG) and LDH. Metastatic disease is initially treated by combination chemotherapy which, in the settings of metastatic seminoma and limited metastatic non-seminomal germ cell tumors, could be the ultimate treatment modality, while the patients with metastatic non-seminomal germ cell tumors with residual metastases after the normalization of serum tumor markers need resection of residual metastases.


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