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Title:Kortikosteroidi pri možganskih tumorjih
Authors:ID Zorko, Nika (Author)
ID Roš-Opaškar, Tanja (Author)
Files:.pdf PDF - Presentation file, download (250,31 KB)
MD5: 716E239CDBB53DEC2BD68B806D44FEDD
PID: 20.500.12556/dirros/d196a9f4-7912-4695-bfb2-1a65a5516ad5
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo OI - Institute of Oncology
Abstract:Kortikosteroidi (KS) se že desetletja uspešno uporabljajo za zmanjševanje obtumorskega edema pri bolnikih z možganskimi tumorji, tako primarnimi kot metastatskimi. Kljub dolgi uporabi niso povsem znani mehanizmi njihovega delovanja v smislu na biološko in klinično učinkovitost. Deksametazon je najbolj uporabljen KS v nevroonkologiji zaradi njegovih ugodnih farmakokinetičnih, farmakodinamičnih in drugih lastnosti. Zaradi številnih možnih neželenih učinkov KS, ki lahko močno okrnijo kakovost bolnikovega življenja, uporabljamo čim nižje še učinkovite odmerke čim krajši možni čas. Številna nova tarčna zdravila za zdravljenje raka, ki zavirajo poti v procesu angiogeneze, izkazujejo učinkovitost tudi v zmanjšanju obtumorskega edema pri bolnikih z možganskimi tumorji.
Keywords:možganski tumorji, kortikosteroidi
Publication status:Published
Publication version:Version of Record
Year of publishing:2012
Number of pages:str. 69-70, 112
Numbering:Letn. 16, št. 2
PID:20.500.12556/DiRROS-9000 New window
UDC:616.831-006.6-085:615.35
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-6HV6DQ1X
COBISS.SI-ID:1422971 New window
Copyright:by Authors
Publication date in DiRROS:31.08.2018
Views:3212
Downloads:752
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Record is a part of a journal

Title:Onkologija. strokovni časopis za zdravnike
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Corticosteroids in brain tumours
Abstract:Corticosteroids (CS) have been used for decades to reduce peritumoral edema in patients with brain tumours, both primary and metastatic. Despite their long use, the mechanisms of their actions are still not completely known in terms of biological and clinical effectiveness. Dexamethasone is the most frequently used CS in neuro-oncology due to its beneficial pharmacokinetic, pharmacodynamic and other properties. As CS have many undesirable effects that can impair the quality of the patient's life, we use the lowest effective doses for the shortest period possible. Several new target medicines for cancer treatment obstruct the paths in the process of angiogenesis, and they are also effective in decreasing the peritumoral edema in patients with brain tumours.


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