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Title: Biološka označevalca p16 in Ki-67 za opredelitev cervikalne intraepitelijske neoplazije v biopsijskih vzorcih materničnega vratu Authors: ID Strojan Fležar, Margareta (Author) ID Gutnik, Helena (Author) Files: PDF - Presentation file, download (1,38 MB) MD5: B53F72CB8DEC6DDCFFCA79DB3FA4BF72 PID: 20.500.12556/dirros/5baccaa4-f4f2-4957-91ae-d0d3ac8f20f2   Language: Slovenian Typology: 1.02 - Review Article Organization: OI - Institute of Oncology Abstract: Biološka označevalca p16 in Ki-67 sta posredna pokazatelja okužbe s humanimi papiloma virusi z velikim tveganjem (HPV-VT), ki so povezani z nastankom predrakavih sprememb na materničnem vratu. V diagnostično težavnih primerih ju lahko uporabimo za razlikovanje cervikalne intraepitelijske neoplazije od morfološko podobnih neneoplastičnih sprememb. Določamo ju lahko s standardnimi imunohistokemičnimi metodami na tkivnih rezinah bioptičnih vzorcev materničnega vratu. Pri vsakdanjem histopatološkem ocenjevanju bioptičnih vzorcev materničnega vratu z dodatnim imunohistokemičnim barvanjem na p16 in Ki-67 največkrat izključimo cervikalno intraepitelijsko neoplazijo visoke stopnje (CIN2 in CIN3), kar prepreči pretirano zdravljenje sprememb na materničnem vratu. Tak diagnostični pristop je uporaben tudi za histopatološko ocenjevanje intraepitelijskih neoplastičnih sprememb endocervikalnega žleznega epitelija. Publication status: Published Publication version: Version of Record Year of publishing: 2012 Number of pages: str. 40-43, 59 Numbering: Letn. 16, št. 1 PID: 20.500.12556/DiRROS-8939  UDC: 618.1 ISSN on article: 1408-1741 URN: URN:NBN:SI:doc-TA1NQNES COBISS.SI-ID: 30073049  Copyright: by Authors Note: BSDOCID165341; Publication date in DiRROS: 31.08.2018 Views: 3001 Downloads: 918 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Onkologija
Shortened title:	Onkologija
Publisher:	Onkološki inštitut
ISSN:	1408-1741
COBISS.SI-ID:	65324032

Licences

License:	CC BY 4.0, Creative Commons Attribution 4.0 International
Link:	http://creativecommons.org/licenses/by/4.0/
Description:	This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:	31.08.2018

Secondary language

Language:	English
Title:	Biological markers p16 and Ki-67 for defining cervical intraepithelial neoplasia in biopsy samples of the cervix
Abstract:	The biological markers p16 and Ki-67 are indirect indicators of high-risk human papillomavirus infections (HR-HPV) connected to the formation of precancerous changes in the cervix. In diagnostically more challenging cases, they can be used to distinguish between cervical intraepithelial neoplasia and morphologically similar non-neoplastic changes. They can be determined using standard immunohistochemical methods on tissue slices from cervical biopsy samples. In the daily histopathological evaluation of the cervical biopsy samples with additional immunohistochemical staining for p16 and Ki-67, a high-grade cervical intraepithelial neoplasia (CIN2 and CIN3) is usually ruled out, which prevents excessive treatment of changes in the cervix. Such diagnostic approach can also be used in the histopathological evaluation of intraepithelial neoplastic changes of the endocervical glandular epithelium.

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