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Title:Pomen zgodnje limfadenektomije pri bolnikih z melanomom
Authors:ID Hočevar, Marko (Author)
ID Pilko, Gašper (Author)
Files:.pdf PDF - Presentation file, download (285,73 KB)
MD5: 10CC19E9D0BF3BEDF902B78F49B77AE9
 
Language:Slovenian
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Publication status:Published
Publication version:Version of Record
Year of publishing:2009
Number of pages:str. 19-21
Numbering:Letn. 13, št. 1
PID:20.500.12556/DiRROS-8813 New window
UDC:616.5-006
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-G5Q09BZ2
COBISS.SI-ID:25692377 New window
Copyright:by Authors
Note:BSDOCID145209;
Publication date in DiRROS:31.08.2018
Views:3429
Downloads:862
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HOČEVAR, Marko and PILKO, Gašper, 2009, Pomen zgodnje limfadenektomije pri bolnikih z melanomom. Onkologija [online]. 2009. Vol. 13, no. 1, p. 19–21. [Accessed 7 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=8813
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Early Lymphadenectomy in Melanoma Patients and Their Prognosis
Abstract:Lymph node metastases are the most important prognostic factor in the patients with cutaneous melanoma and they are treated with radical lymphadenectomy. In the last 15 years, sentinel lymph node biopsy (SLNB) became the method of choice in staging regional lymph nodes in melanoma patients. The procedure provides the most accurate prognostic information and facilitates early lymphadenectomy in the patients with clinically occult regional metastases, however, therapeutic value of SLNB followed by completion lymph node dissection (CLND) in melanoma patients has not been proved. The reason might be prognostic heterogeneity of patients with positive sentinel lymph node (SN); hence, the aim of this study was to assess survival rates of these patients. For the purpose of this analysis, the patients with stage III melanoma were identified from the prospective melanoma database at the Institute of Oncology Ljubljana, Slovenia, which includes more than 1000 patients. Patients were divided into four groups: • delayed therapeutic lymph node dissection (TLND) • CLND after positive SLNB • synchronous primary melanoma and regional lymph node metastases • lymph node metastases for unknown primaries The worst 5-year overall survival (OS) had the patients with synchronous primary melanoma and regional lymph node metastases. The patients with SN metastases with a diameter of more than 5.0 mm had significantly worse OS than those with delayed TLND, while the patients with SLNB metastases with a diameter of 5.0 mm or less had significantly better OS than those with delayed TLND even after the patients with false positive SLNB (diameter less than 0.3 mm) were excluded. The group of patients with positive SLNB is contaminated with the false positive patients as well as with the patients with more aggressive disease. The majority of SN positive patients, however, have an OS benefit in comparison to the patients with delayed TLND.


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