| Title: | Assessment of three criteria to establish borrelial infection in suspected lyme neuroborreliosis |
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| Authors: | ID Ogrinc, Katarina (Author)
ID Bogovič, Petra (Author)
ID Maraspin-Čarman, Vera (Author)
ID Lotrič-Furlan, Stanka (Author)
ID Rojko, Tereza (Author)
ID Ružić-Sabljić, Eva (Author)
ID Kastrin, Andrej (Author)
ID Strle, Klemen (Author)
ID Wormser, Gary P. (Author)
ID Strle, Franc (Author) |
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| Files: |  PDF - Presentation file, download (1,16 MB)
MD5: BF51A8257ED6D9B2CDDA5399CDBC2BAA
 URL - Source URL, visit https://link.springer.com/article/10.1007/s15010-024-02338-2
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Purpose: Diagnosis of (European) Lyme neuroborreliosis has been based on clinical presentation, cerebrospinal fluid (CSF) pleocytosis and demonstration of intrathecal borrelial antibody synthesis (ITBAS) to document Borrelia burgdorferi s. l. infection. It is not known if other criteria to document Borrelia infection may contribute to the diagnosis. Methods: We compared the sensitivity of three individual criteria (ITBAS, CSF Borrelia culture, and the presence of erythema migrans [EM]) to confirm the diagnosis of early Lyme neuroborreliosis in 280 patients≥15 years of age evaluated at a Lyme borreliosis outpatient clinic in Slovenia. The patients had either radicular pain of new onset or involvement of a cranial nerve but without radicular pain, each in conjunction with CSF pleocytosis. Evaluation was of patients who had each of the three confirmatory criteria assessed, and for whom at least one criterion was positive. Results: Analysis of 280 patients, 120 women and 160 men, median age 57 (range 15–84) years, revealed that ITBAS was the most frequently observed positive criterion (85.4%), followed by EM (52.9%), and by a positive CSF Borrelia culture (9.6%). Of the 280 patients, 154 (55%) met only one criterion (43.2% ITBAS only, 10.7% EM only, and 1.1% positive CSF culture only), whereas 42.1% met two criteria. Only 2.9% of patients were positive by all three criteria. Conclusion: Although ITBAS was the most frequent criterion for confirmation for Borrelia infection, the presence of EM alone confirmed an additional 10.7% of patients and a positive CSF Borrelia culture alone added another 1.1%. |
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| Keywords: | lyme neuroborreliosis, intrathecal borrelial antibody synthesis, erythema migrans, Borrelia burgdorferi |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 165-174 |
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| Numbering: | Vol. 53, iss. 1 |
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| PID: | 20.500.12556/DiRROS-24587  |
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| UDC: | 616.9 |
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| ISSN on article: | 0300-8126 |
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| DOI: | 10.1007/s15010-024-02338-2 |
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| COBISS.SI-ID: | 220351747 |
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| Publication date in DiRROS: | 08.12.2025 |
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| Views: | 88 |
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| Downloads: | 49 |
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