| Naslov: | Proportion of confirmed Lyme neuroborreliosis cases among adult patients with suspected early European Lyme neuroborreliosis |
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| Avtorji: | ID Ogrinc, Katarina (Avtor)
ID Bogovič, Petra (Avtor)
ID Rojko, Tereza (Avtor)
ID Maraspin-Čarman, Vera (Avtor)
ID Ružić-Sabljić, Eva (Avtor)
ID Kastrin, Andrej (Avtor)
ID Strle, Klemen (Avtor)
ID Wormser, Gary P. (Avtor)
ID Strle, Franc (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,07 MB)
MD5: 23E6F9953F186877A5DBA6E13F78578A
 URL - Izvorni URL, za dostop obiščite https://link.springer.com/article/10.1007/s15010-024-02461-0
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Purpose To determine the frequency of confirmed Lyme neuroborreliosis (LNB) cases in adult patients with three different clinical presentations consistent with early LNB. Methods Data were obtained through routine health care at the UMC Ljubljana, Slovenia from 2005 to 2022, using clinical pathways. The patients were classified into three groups: (i) radicular pain of new onset (N=332); or (ii) involvement of cranial nerve(s) but without radicular pain (N=997); or (iii) erythema migrans (EM) skin lesion(s) in conjunction with symptoms suggestive of nervous system involvement but without either cranial nerve palsy or radicular pain (N=240). The diagnosis of LNB considered the following variables: the presence of: (1) neurologic symptoms consistent with LNB (with no other obvious explanation); (2) cerebrospinal fluid (CSF) pleocytosis (>5×▫$10^$▫ leukocytes/L); and (3) demonstration of intrathecal synthesis of borrelial antibodies, and/or cultivation of borrelia from CSF, and/or the presence of EM. Patients fulfilling only the first two criteria were interpreted as having possible LNB, while those who satisfied all three criteria were regarded as having confirmed LNB. Results Of 1569 adult patients, 348 (22.2%) had confirmed LNB and 70 (4.5%) others had possible LNB. The proportion of confirmed LNB cases was the highest for patients with radicular pain (217/332, 65.4%), followed by the group with EM and neurologic symptoms (47/240, 19.6%), and those with cranial neuritis (84/997, 8.4%). Conclusion Only 22% of patients evaluated had confirmed LNB. The proportion of confirmed LNB cases correlated with clinical presentation and was highest among patients with recent onset of radicular pain. |
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| Ključne besede: | Lyme borreliosis, Lyme neuroborreliosis, criteria, cerebrospinal fluid, Bannwarth syndrome, cranial neuritis, borrelial meningitis, intrathecal borrelial antibody synthesis, Borrelia culture |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2025 |
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| Št. strani: | str. 1403–1412 |
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| Številčenje: | Vol. 53, issue 4 |
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| PID: | 20.500.12556/DiRROS-24540  |
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| UDK: | 616.9 |
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| ISSN pri članku: | 0300-8126 |
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| DOI: | 10.1007/s15010-024-02461-0 |
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| COBISS.SI-ID: | 237288707 |
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| Datum objave v DiRROS: | 04.12.2025 |
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| Število ogledov: | 24 |
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| Število prenosov: | 13 |
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| Metapodatki: |    |
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