| Title: | Case report: effectiveness of Janus kinase inhibitors in the management of isolated noninfectious uveitis : a case series |
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| Authors: | ID Krhlikar, Nina (Author)
ID Tomšič, Matija (Author)
ID Jaki Mekjavić, Polona (Author)
ID Klobučar, Pia (Author)
ID Vidović Valentinčič, Nataša (Author) |
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| Files: |  PDF - Presentation file, download (4,01 MB)
MD5: 3F0B4A738BFFD5FB12FA2D6F336ECCEC
 URL - Source URL, visit https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1509404/full
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| Language: | English |
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| Typology: | 1.03 - Other scientific articles |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Purpose: This study aimed to assess the efficacy of Janus kinase inhibitors (JAK-i) in the treatment of refractory isolated non-infectious uveitis. Case presentation: We examined a case series involving three patients with isolated non-infectious uveitis, who were managed between December 2019 and December 2023 at The Eye Hospital, University Medical Centre Ljubljana. The JAK-i therapy was initiated due to the patients’ unresponsiveness to disease-modifying antirheumatic drugs. Outcomes: In our case series, two patients presented with anterior and intermediate uveitis, one with posterior uveitis. None of the patients had any associated systemic disease. After the initiation of JAK-I therapy, all the patients achieved remission lasting for more than 1 year. No significant side effects were observed in any of the patients throughout a mean follow-up period of 31.6 months (range, 16–55 months). Conclusion: In this report, we present three cases of refractory isolated non-infectious uveitis successfully treated with JAK-i. This is the first report on the use of baricitinib and upadacitinib in this context. Our findings suggest that alternative use of JAK-i, apart from tofacitinib alone, may be an effective treatment option for such patients. |
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| Keywords: | JAK inhibitors, uveitis, biologics |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | 7 str. |
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| Numbering: | Vol. 16, [article no.] 1509404 |
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| PID: | 20.500.12556/DiRROS-24535  |
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| UDC: | 61 |
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| ISSN on article: | 1663-9812 |
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| DOI: | 10.3389/fphar.2025.1509404 |
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| COBISS.SI-ID: | 237141507 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 26. 5. 2025;
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| Publication date in DiRROS: | 04.12.2025 |
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| Views: | 12 |
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| Downloads: | 5 |
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