| Title: | Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery |
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| Authors: | ID Dovč, Klemen (Author)
ID Spanbauer, Charles (Author)
ID Chiarle, Eleonora (Author)
ID Bratina, Nataša (Author)
ID Fröhlich-Reiterer, Elke (Author)
ID Potočnik, Nejka (Author)
ID Zaharieva, Dessi P. (Author)
ID Hropot, Tim (Author)
ID Fritsch, Maria (Author)
ID Calhoun, Peter (Author)
ID Battelino, Tadej (Author) |
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| Files: |  PDF - Presentation file, download (766,06 KB)
MD5: 733B1B0811B4F1A49D7E9469BA038D3C
 URL - Source URL, visit https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.16211
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Aims The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10–18 years) with type 1 diabetes. Materials and Methods We undertook a secondary analysis of postprandial glycaemic outcomes from a double-blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70–140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC). Results The mean ± SD age of 30 included participants was 15.0 ± 1.7 years, 47% were male, mean HbA1c was 7.5% ± 0.9% (58 ± 9.8 mmol/mol) and the number of meals per day per participant was 3.2 ± 1.2 meals. Overall, the postprandial outcomes were improved with FIA compared with SIA. Mean glucose at the start of the meal was 151 mg/dL in the FIA group and reached a peak glucose of 194 mg/dL, compared with starting level of 151 mg/dL in the SIA group and a peak of 198 mg/dL (difference in excursion: −3.8 mg/dL; 95% confidence interval −5.8 to −1.7; p <0.001). FIA group also had a 1.9% increase in mean TITR (p = 0.02) and a 2.0-mg/dL decrease in mean iAUC (p = 0.003). Differences in outcomes were the most noticeable for breakfast, meals with a larger amount of carbohydrates (>45 g) and participants with lower insulin-to-carbohydrate ratios.Conclusions Faster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets. |
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| Keywords: | postprandial time in tight, range standard insulin aspart in youth with type 1, automated insulin delivery |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 2147-2153 |
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| Numbering: | Vol. 27, iss. 4 |
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| PID: | 20.500.12556/DiRROS-24516  |
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| UDC: | 616.379 |
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| ISSN on article: | 1462-8902 |
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| DOI: | 10.1111/dom.16211 |
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| COBISS.SI-ID: | 235096323 |
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| Publication date in DiRROS: | 03.12.2025 |
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| Views: | 42 |
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| Downloads: | 13 |
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