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Title:Vloga fukozil- in sialiltransferaz pri rakavih obolenjih in procesu metastaziranja
Authors:ID Čuš, Tilen (Author)
ID Kočevar Glavač, Nina (Author)
ID Mravljak, Janez (Author)
Files:.pdf PDF - Presentation file, download (701,12 KB)
MD5: FC46350693F3445975C9A67FD42573C8
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo SFD - Slovenian Pharmaceutical Society
Abstract:Rakave bolezni so eden izmed vodilnih vzrokov umrljivosti v razvitem svetu, pri čemer je 90 % smrti bolnikov z rakom povezanih z metastaziranjem. gre za zapleten proces, ki vključuje številne biokemične spremembe, med katerimi so pogoste tudi spremembe v celični glikozilaciji, zlasti sializaciji ter fukozilaciji. Ključno vlogo pri tem igrajo encimi sialil- in fukoziltransferaze, ki katalizirajo vezavo sialične kisline in fukoze na ustrezne substrate. Spremembe v njihovem izražanju opazimo pri številnih rakih, kjer lahko pripeljejo do sprememb v adheziji celic, proliferaciji, gibljivosti, ožiljenosti tumorja in izogibanju rakavih celic pred imunskim sistemom, kar lahko pomembno ojača metastatski potencial rakavih celic. hkrati je povišana aktivnost sialil- in fukoziltransferaz povezana s številnimi rakavimi boleznimi, kot so rak dojk, debelega črevesja in pankreasa. Razumevanje njihove vloge v fizioloških in patofizioloških stanjih tako ponuja nove možnosti v zdravljenju in diagnostiki.
Keywords:fukoziltransferaze, glikozilacija, sialiltransferaze
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2025
Year of publishing:2025
Number of pages:str. 22-29
Numbering:Letn. 76, Št. 1
PID:20.500.12556/DiRROS-22881 New window
UDC:616-033.2:615.2
ISSN on article:0014-8229
COBISS.SI-ID:230961923 New window
Publication date in DiRROS:08.07.2025
Views:384
Downloads:142
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Record is a part of a journal

Title:Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:English
Title:The role of fucosyl- and sialyltransferases in cancer and metastasis
Abstract:Cancer is one of the leading causes of mortality in the developed world, with 90% of cancer-related deaths being associated with metastasis. This is a complex process involving numerous biochemical changes, including alterations in cellular glycosylation – particularly sialylation and fucosylation. In this process, sialyl- and fucosyltransferases are central enzymes that catalyze the attachment of sialic acid and fucose to their corresponding substrates. Changes in their expression can be observed in various cancers, where they may lead to alterations in cell adhesion, proliferation, motility, tumor angiogenesis, and immune system evasion, significantly enhancing the metastatic potential of cancer cells. Additionally, their increased activity is linked to various types of cancer, such as breast, colon, and pancreatic cancers. Understanding their role in both physiological and pathological conditions offers new possibilities for innovative approaches in cancer treatment and diagnosis,


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  1. Farmacevtski vestnik

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