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Title:Nanotehnološki pristopi za zdravljenje Alzheimerjeve bolezni
Authors:ID Nemec, Sebastjan (Author)
ID Knez, Damijan (Author)
ID Kocbek, Petra (Author)
ID Kralj, Slavko (Author)
Files:URL URL - Source URL, visit https://www.sfd.si/wp-content/uploads/2025/03/clanek-4_1_2025.pdf
 
.pdf PDF - Presentation file, download (1,13 MB)
MD5: 9D0C77CC7AD0F46964B1D4159C46BF3C
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo SFD - Slovenian Pharmaceutical Society
Abstract:Alzheimerjeva bolezen je neozdravljiva nevrodegenerativna bolezen, za katero je značilno propadanje živčnih celic in izguba kognitivnih funkcij. Trenutno odobrena zdravila naslavljajo predvsem simptome bolezni. številne nove potencialne zdravilne učinkovine, ki vplivajo tudi na potek bolezni, pa so se v kliničnih raziskavah izkazale kot sorazmerno ne - uspešne. S tem razlogom v središče raziskav prihajajo novi pristopi zdravljenja Alzheimerjeve bolezni, ki temeljijo na uporabi nanotehnologije. Izvedena je bila že vrsta raziskav, v katerih so proučevali vplive različnih nanodelcev na tarče, povezane z nastankom in razvojem te bolezni. Proučevali so učinke polimernih nanodelcev, nanodelcev zlata ter železovega oksida na samozdruževanje monomerov amiloida β in proteina tau v agregate, kot tudi uporabo omenjenih nanodelcev za razgradnjo že nastalih agregatov proteinov. Izsledki teh raziskav predstavljajo pomembno izhodišče za nadaljnje raziskave in razvoj nanotehnoloških pristopov za razgradnjo agregiranih proteinskih struktur in razvoj novih možnosti zdravljenja različnih bolezni, ki jih povezujemo s patološkim nastajanjem proteinskih agregatov.
Keywords:protein tau, amolid beta
Publication status:Published
Publication version:Version of Record
Publication date:01.03.2025
Year of publishing:2025
Number of pages:str. 30-38
Numbering:Letn. 76, Št. 1
PID:20.500.12556/DiRROS-22878 New window
UDC:620.3
ISSN on article:2536-4316
COBISS.SI-ID:230471683 New window
Note:Nasl. z nasl. zaslona; Besedilo v slov.; Soavtorji: Damijan Knez, Petra Kocbek, Slavko Kralj; Opis vira z dne 27. 3. 2025;
Publication date in DiRROS:08.07.2025
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Downloads:257
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Record is a part of a journal

Title:Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Publisher:Slovensko farmacevtsko društvo
ISSN:2536-4316
COBISS.SI-ID:288686336 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P2-0089
Name:Sodobni magnetni in večnamenski materiali

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0208
Name:Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0420
Name:Napredna imunološka zdravila in celični pristopi v farmaciji

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J2-60047
Name:Magnetno mikrostrukturiranje površin iz Mg zlitine za izboljšano endotelizacijo in zadržano razgradljivost materialov žilnih opornic

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J2-3043
Name:Izkoriščanje magneto-mehanskega učinka pri zdravljenju nevrodegenerativnih bolezni

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J3-3079
Name:Baktericidna nanorezila: preizkus bimodalnega mehanokemijskega odstranjevanja trdovratnih biofilmov

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J7-4420
Name:Selektivno mehansko odstranjevanje bakterijskih biofilmov s konjugiranimi magnetnimi nanodelci

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:L2-60141
Name:Izboljšanje delovanja toplotnega izmenjevalca z inovativno superhidrofobno prevleko; Super-COR-AI

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:BI-FR/23-24-PROTEUS-005
Name:Anizotropni magnetni nanodelci za in-vitro in in-vivo raziskave zdravljenja raka z magneto-mehanskim pristopom

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:BI-RS/23-25-030
Name:Anizotropni nanodelci železovega oksida za uporabo v medicini: magneto-mehanski učinek in hipertermija

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:English
Title:Nanotechnology-based approaches for the treatment of Alzheimer’s disease
Abstract:Alzheimer’s disease is an incurable neurodegenerative disease characterized by the degeneration of neurons and the deterioration of cognitive functions. The currently approved drugs primarily address the symptoms of the disease and potential new drugs have been relatively unsuccessful in clinical trials. Due to the failure of these new agents, new approaches to treating Alzheimer’s disease have come to the forefront of research, including approaches from the field of nanotechnology. There is already a number of studies where the effect of mainly polymer, gold, and iron oxide nanoparticles in preventing the self-aggregation of amyloid β monomers and tau protein is investigated. In addition, these nanoparticles are also being investigated for their ability to disaggregate already formed aggregates of amyloid β and tau protein. The available research provides a baseline for further investigation of nano - technological processes for the development of new treatment options for various diseases, in addition to Alzheimer’s, that are associated with pathological protein aggregation.
Keywords:tau protein, amyloid beta


Collection

This document is a part of these collections:
  1. Farmacevtski vestnik

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