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Naslov:Impact of indoor air pollution on DNA damage and chromosome stability : a systematic review
Avtorji:ID Kazensky, Luka (Avtor)
ID Matković, Katarina (Avtor)
ID Gerić, Marko (Avtor)
ID Žegura, Bojana (Avtor)
ID Pehnec, Gordana (Avtor)
ID Gajski, Goran (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1007/s00204-024-03785-4
 
.pdf PDF - Predstavitvena datoteka, prenos (825,18 KB)
MD5: 420609F59C5C6014504C8C1C56B95E75
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Indoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households. Burning these fuels produces harmful compounds, such as particulate matter regarded as a major health risk, particularly affecting the onset and exacerbation of respiratory diseases. As exposure to polluted indoor air can cause DNA damage including DNA sd breaks as well as chromosomal damage, in this paper, we aim to provide an overview of the impact of indoor air pollution on DNA damage and genome stability by reviewing the scientific papers that have used the comet, micronucleus, and γ-H2AX assays. These methods are valuable tools in human biomonitoring and for studying the mechanisms of action of various pollutants, and are readily used for the assessment of primary DNA damage and genome instability induced by air pollutants by measuring different aspects of DNA and chromosomal damage. Based on our search, in selected studies (in vitro, animal models, and human biomonitoring), we found generally higher levels of DNA strand breaks and chromosomal damage due to indoor air pollutants compared to matched control or unexposed groups. In summary, our systematic review reveals the importance of the comet, micronucleus, and γ-H2AX assays as sensitive tools for the evaluation of DNA and genome damaging potential of different indoor air pollutants. Additionally, research in this particular direction is warranted since little is still known about the level of indoor air pollution in households or public buildings and its impact on genetic material. Future studies should focus on research investigating the possible impact of indoor air pollutants in complex mixtures on the genome and relate pollutants to possible health outcomes.
Ključne besede:indoor air quality, genome damage, comet assay, micronucleus assay, γ-H2AX assay, health risk
Status publikacije:Objavljeno
Verzija publikacije:Nerecenzirani rokopis
Datum objave:28.05.2024
Leto izida:2024
Št. strani:str. 2817-2841
Številčenje:Vol. 98, iss. 9
UDK:577
ISSN pri članku:0340-5761
DOI:10.1007/s00204-024-03785-4 Novo okno
COBISS.SI-ID:197439235 Novo okno
Opomba:Soavtorji: Katarina Matković, Marko Gerić, Bojana Žegura, Gordana Pehnec & Goran Gajski;
Datum objave v DiRROS:06.11.2024
Število ogledov:30
Število prenosov:11
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Archives of toxicology
Skrajšan naslov:Arch Toxicol
Založnik:Springer
ISSN:0340-5761
COBISS.SI-ID:562452 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P1-0245-2019
Naslov:Ekotoksiologija, toksikološka genomika in karcinogeneza

Financer:EC - European Commission
Številka projekta:101057497
Naslov:EVIDENCE DRIVEN INDOOR AIR QUALITY IMPROVEMENT
Akronim:EDIAQI

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Croatian Science Foundation
Številka projekta:1192

Financer:Drugi - Drug financer ali več financerjev
Program financ.:European Union, European Regional Development Fund
Številka projekta:KK.01.1.1.02.0007
Naslov:Research and Education Centre of Environmental Health and Radiation Protection— Reconstruction and Expansion of the Institute for Medical Research and Occupational Health

Financer:Drugi - Drug financer ali več financerjev
Program financ.:European Union, Next Generation EU
Številka projekta:533-03-23-0006
Akronim:BioMolTox and EnvironPollutHealth

Licence

Licenca:InC, In Copyright
Povezava:http://rightsstatements.org/vocab/InC/1.0/
Opis:Namenjena je uporabi za digitalne objekte z avtorskimi pravicami, ki so prosto dostopni na spletu in kadar ponovna uporaba zahteva dodatno dovoljenje imetnikov pravic.

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review
Ključne besede:onesnaženje zraka zaprtih prostorov, DNK poškodbe, test komet, test mikrojeder, γ-H2AX test, tveganje za zdravje


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