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Title:Impact of indoor air pollution on DNA damage and chromosome stability : a systematic review
Authors:ID Kazensky, Luka (Author)
ID Matković, Katarina (Author)
ID Gerić, Marko (Author)
ID Žegura, Bojana (Author)
ID Pehnec, Gordana (Author)
ID Gajski, Goran (Author)
Files:URL URL - Source URL, visit https://doi.org/10.1007/s00204-024-03785-4
 
.pdf PDF - Presentation file, download (825,18 KB)
MD5: 420609F59C5C6014504C8C1C56B95E75
 
Language:English
Typology:1.02 - Review Article
Organization:Logo NIB - National Institute of Biology
Abstract:Indoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households. Burning these fuels produces harmful compounds, such as particulate matter regarded as a major health risk, particularly affecting the onset and exacerbation of respiratory diseases. As exposure to polluted indoor air can cause DNA damage including DNA sd breaks as well as chromosomal damage, in this paper, we aim to provide an overview of the impact of indoor air pollution on DNA damage and genome stability by reviewing the scientific papers that have used the comet, micronucleus, and γ-H2AX assays. These methods are valuable tools in human biomonitoring and for studying the mechanisms of action of various pollutants, and are readily used for the assessment of primary DNA damage and genome instability induced by air pollutants by measuring different aspects of DNA and chromosomal damage. Based on our search, in selected studies (in vitro, animal models, and human biomonitoring), we found generally higher levels of DNA strand breaks and chromosomal damage due to indoor air pollutants compared to matched control or unexposed groups. In summary, our systematic review reveals the importance of the comet, micronucleus, and γ-H2AX assays as sensitive tools for the evaluation of DNA and genome damaging potential of different indoor air pollutants. Additionally, research in this particular direction is warranted since little is still known about the level of indoor air pollution in households or public buildings and its impact on genetic material. Future studies should focus on research investigating the possible impact of indoor air pollutants in complex mixtures on the genome and relate pollutants to possible health outcomes.
Keywords:indoor air quality, genome damage, comet assay, micronucleus assay, γ-H2AX assay, health risk
Publication status:Published
Publication version:Submitted Version
Publication date:28.05.2024
Year of publishing:2024
Number of pages:str. 2817-2841
Numbering:Vol. 98, iss. 9
PID:20.500.12556/DiRROS-20780 New window
UDC:577
ISSN on article:0340-5761
DOI:10.1007/s00204-024-03785-4 New window
COBISS.SI-ID:197439235 New window
Note:Soavtorji: Katarina Matković, Marko Gerić, Bojana Žegura, Gordana Pehnec & Goran Gajski;
Publication date in DiRROS:06.11.2024
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Downloads:56
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Record is a part of a journal

Title:Archives of toxicology
Shortened title:Arch Toxicol
Publisher:Springer
ISSN:0340-5761
COBISS.SI-ID:562452 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza

Funder:EC - European Commission
Project number:101057497
Name:EVIDENCE DRIVEN INDOOR AIR QUALITY IMPROVEMENT
Acronym:EDIAQI

Funder:Other - Other funder or multiple funders
Funding programme:Croatian Science Foundation
Project number:1192

Funder:Other - Other funder or multiple funders
Funding programme:European Union, European Regional Development Fund
Project number:KK.01.1.1.02.0007
Name:Research and Education Centre of Environmental Health and Radiation Protection— Reconstruction and Expansion of the Institute for Medical Research and Occupational Health

Funder:Other - Other funder or multiple funders
Funding programme:European Union, Next Generation EU
Project number:533-03-23-0006
Acronym:BioMolTox and EnvironPollutHealth

Licences

License:InC, In Copyright
Link:http://rightsstatements.org/vocab/InC/1.0/
Description:The InC statement is for use with in copyright Digital Objects which are freely available online and where re-use requires additional permission from the rights holder(s).

Secondary language

Language:Slovenian
Title:Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review
Keywords:onesnaženje zraka zaprtih prostorov, DNK poškodbe, test komet, test mikrojeder, γ-H2AX test, tveganje za zdravje


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