| Title: | Dynamic balance and gait impairments in Parkinson’s disease : novel cholinergic patterns |
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| Authors: | ID Bohnen, Nicolaas I. (Author)
ID Marušič, Uroš (Author)
ID Roytman, Stiven (Author)
ID Paalanen, Rebecca (Author)
ID Michalakis, Fotini (Author)
ID Brown, Taylor (Author)
ID Scott, Peter J. H. (Author)
ID Carli, Giulia (Author)
ID Albin, Roger (Author)
ID Kanel, Prabesh (Author) |
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| Files: |  URL - Source URL, visit https://doi.org/10.1093/braincomms/fcae286
 PDF - Presentation file, download (4,32 MB)
MD5: 28A524FF82EA910A61D1734F8D586013
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  ZRS Koper - Science and Research Centre Koper
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| Abstract: | The cholinergic system has been implicated in postural deficits, in particular falls, in Parkinson’s disease.
Falls and freezing of gait typically occur during dynamic and challenging balance and gait conditions,
such as when initiating gait, experiencing postural perturbations, or making turns. However, the precise
cholinergic neural substrate underlying dynamic postural and gait changes remains poorly understood.
The aim of this study was to investigate whether brain vesicular acetylcholine transporter binding, as
measured with [18F]-fluoroethoxybenzovesamicolbinding PET, correlates with dynamic gait and balance
impairments in 125 patients with Parkinson’s disease (mean age 66.89±7.71 years) using the abbreviated
Balance Evaluation Systems Test total and its four functional domain sub-scores (anticipatory postural
control, reactive postural control, dynamic gait, and sensory integration). Whole brain false discoverycorrected (P < 0.05) correlations for total abbreviated Balance Evaluation Systems Test scores included
the following bilateral or asymmetric hemispheric regions: gyrus rectus, orbitofrontal cortex, anterior part
of the dorsomedial prefrontal cortex, dorsolateral prefrontal cortex, cingulum, frontotemporal opercula,
insula, fimbria, right temporal pole, mesiotemporal, parietal and visual cortices, caudate nucleus, lateral
and medial geniculate bodies, thalamus, lingual gyrus, cerebellar hemisphere lobule VI, left cerebellar
crus I, superior cerebellar peduncles, flocculus, and nodulus. No significant correlations were found for
the putamen or anteroventral putamen. The four domain-specific sub-scores demonstrated overlapping
cholinergic topography in the metathalamus, fimbria, thalamus proper, and prefrontal cortices but also
showed distinct topographic variations. For example, reactive postural control functions involved the right
flocculus but not the upper brainstem regions. The anterior cingulum associated with reactive postural
control whereas the posterior cingulum correlated with anticipatory control. The spatial extent of
associated cholinergic system changes were least for dynamic gait and sensory orientation functional
domains compared to the anticipatory and reactive postural control functions. We conclude that specific
aspects of dynamic balance and gait deficits in Parkinson’s disease associate with overlapping but also
distinct patterns of cerebral cholinergic system changes in numerous brain regions. Our study also presents
novel evidence of cholinergic topography involved in dynamic balance and gait in Parkinson’s disease
that have not been typically associated with mobility disturbances, such as the right anterior temporal pole,
right anterior part of the dorsomedial prefrontal cortex, gyrus rectus, fimbria, lingual gyrus, flocculus,
nodulus and right cerebellar hemisphere lobules VI and left crus I. |
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| Keywords: | Parkinson’s disease, dynamic balance, cholinergic, PET |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 26.08.2024 |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-36 |
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| Numbering: | Vol. , iss. |
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| PID: | 20.500.12556/DiRROS-20249  |
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| UDC: | 616.858 |
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| ISSN on article: | 2632-1297 |
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| DOI: | 10.1093/braincomms/fcae286 |
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| COBISS.SI-ID: | 205843203 |
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| Copyright: | The authors |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 30.8.2024;
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| Publication date in DiRROS: | 30.08.2024 |
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| Views: | 15 |
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| Downloads: | 9 |
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