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Naslov:Hepatic alterations in a BTBR T + Itpr3tf/J mouse model of autism and improvement using melatonin via mitigation oxidative stress, inflammation and ferroptosis
Avtorji:ID Rezzani, Rita (Avtor)
ID Gianò, Marzia (Avtor)
ID Pinto, Daniela (Avtor)
ID Rinaldi, Fabio (Avtor)
ID Noorden, Cornelis J. F. van (Avtor)
ID Favero, Gaia (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/1422-0067/25/2/1086
 
.pdf PDF - Predstavitvena datoteka, prenos (12,47 MB)
MD5: 335DEDB060BD841A9D8D6311D16F8742
 
URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.3390/ijms25021086
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this disorder. The aims of the present study were to analyze morphological and biological alterations in the liver of an autistic mouse model, BTBR T + Itpr3tf/J (BTBR) mice, and to identify therapeutic strategies for alleviating hepatic impairments using melatonin administration. We studied hepatic cytoarchitecture, oxidative stress, inflammation and ferroptosis in BTBR mice and used C57BL6/J mice as healthy control subjects. The mice were divided into four groups and then treated and not treated with melatonin, respectively. BTBR mice showed (a) a retarded development of livers and (b) iron accumulation and elevated oxidative stress and inflammation. We demonstrated that the expression of ferroptosis markers, the transcription factor nuclear factor erythroid-related factor 2 (NFR2), was upregulated, and the Kelch-like ECH-associated protein 1 (KEAP1) was downregulated in BTBR mice. Then, we evaluated the effects of melatonin on the hepatic alterations of BTBR mice; melatonin has a positive effect on liver cytoarchitecture and metabolic functions.
Ključne besede:autism spectrum disorder, liver, oxidative stress, inflammation, ferroptosis
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:16.01.2024
Leto izida:2024
Št. strani:str. 1-20
Številčenje:Vol. 25, no. 2, [article no.] 1086
PID:20.500.12556/DiRROS-20180 Novo okno
UDK:577.2
ISSN pri članku:1422-0067
DOI:10.3390/ijms25021086 Novo okno
COBISS.SI-ID:190985987 Novo okno
Opomba:Nasl. z nasl. zaslona; Soavtorji: Marzia Gianò, Daniela Pinto, Fabio Rinaldi, Cornelis J. F. van Noorden and Gaia Favero; Opis vira z dne 31. 3. 2024;
Datum objave v DiRROS:07.08.2024
Število ogledov:480
Število prenosov:366
Metapodatki:XML DC-XML DC-RDF
:
REZZANI, Rita, GIANÒ, Marzia, PINTO, Daniela, RINALDI, Fabio, NOORDEN, Cornelis J. F. van in FAVERO, Gaia, 2024, Hepatic alterations in a BTBR T + Itpr3tf/J mouse model of autism and improvement using melatonin via mitigation oxidative stress, inflammation and ferroptosis. International journal of molecular sciences [na spletu]. 2024. Vol. 25, no. 2,  1086, p. 1–20. [Dostopano 9 april 2025]. DOI 10.3390/ijms25021086. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20180
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Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P1-0245-2019
Naslov:Ekotoksiologija, toksikološka genomika in karcinogeneza
Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J3-2526-2020
Naslov:Razkrivanje niše matičnih glioma celic v iskanju novih terapevtskih ciljev pri bolnikih z glioblastomom

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Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
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