| Title: | Hepatic alterations in a BTBR T + Itpr3tf/J mouse model of autism and improvement using melatonin via mitigation oxidative stress, inflammation and ferroptosis |
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| Authors: | ID Rezzani, Rita (Author)
ID Gianò, Marzia (Author)
ID Pinto, Daniela (Author)
ID Rinaldi, Fabio (Author)
ID Noorden, Cornelis J. F. van (Author)
ID Favero, Gaia (Author) |
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| Files: |  URL - Source URL, visit https://www.mdpi.com/1422-0067/25/2/1086
 PDF - Presentation file, download (12,47 MB)
MD5: 335DEDB060BD841A9D8D6311D16F8742
URL - Source URL, visit https://doi.org/10.3390/ijms25021086
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this disorder. The aims of the present study were to analyze morphological and biological alterations in the liver of an autistic mouse model, BTBR T + Itpr3tf/J (BTBR) mice, and to identify therapeutic strategies for alleviating hepatic impairments using melatonin administration. We studied hepatic cytoarchitecture, oxidative stress, inflammation and ferroptosis in BTBR mice and used C57BL6/J mice as healthy control subjects. The mice were divided into four groups and then treated and not treated with melatonin, respectively. BTBR mice showed (a) a retarded development of livers and (b) iron accumulation and elevated oxidative stress and inflammation. We demonstrated that the expression of ferroptosis markers, the transcription factor nuclear factor erythroid-related factor 2 (NFR2), was upregulated, and the Kelch-like ECH-associated protein 1 (KEAP1) was downregulated in BTBR mice. Then, we evaluated the effects of melatonin on the hepatic alterations of BTBR mice; melatonin has a positive effect on liver cytoarchitecture and metabolic functions.
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| Keywords: | autism spectrum disorder, liver, oxidative stress, inflammation, ferroptosis |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 16.01.2024 |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-20 |
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| Numbering: | Vol. 25, no. 2, [article no.] 1086 |
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| PID: | 20.500.12556/DiRROS-20180  |
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| UDC: | 577.2 |
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| ISSN on article: | 1422-0067 |
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| DOI: | 10.3390/ijms25021086 |
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| COBISS.SI-ID: | 190985987 |
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| Note: | Nasl. z nasl. zaslona;
Soavtorji: Marzia Gianò, Daniela Pinto, Fabio Rinaldi, Cornelis J. F. van Noorden and Gaia Favero;
Opis vira z dne 31. 3. 2024;
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| Publication date in DiRROS: | 07.08.2024 |
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| Views: | 316 |
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| Downloads: | 247 |
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