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Naslov:Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches
Avtorji:ID Hira, Vashendriya V. V. (Avtor)
ID Noorden, Cornelis J. F. van (Avtor)
ID Carraway, Hetty E. (Avtor)
ID Maciejewski, Jaroslaw P. (Avtor)
ID Molenaar, Remco J. (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0304419X1630124X?via%3Dihub
 
.pdf PDF - Predstavitvena datoteka, prenos (1,69 MB)
MD5: EF8B282F389F5BC262619AD3144429D6
 
URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1016/j.bbcan.2017.03.010
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Acute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and become leukemic stem cells (LSCs) at the expense of normal HSCs. LSCs are quiescent and resistant to chemotherapy and can cause relapse of the disease. HSCs in niches are needed to generate blood cell precursors that are committed to unilineage differentiation and eventually production of mature blood cells, including red blood cells, megakaryocytes, myeloid cells and lymphocytes. Thus far, three types of HSC niches are recognized: endosteal, reticular and perivascular niches. However, we argue here that there is only one type of HSC niche, which consists of a periarteriolar compartment and a perisinusoidal compartment. In the periarteriolar compartment, hypoxia and low levels of reactive oxygen species preserve the HSC pool. In the perisinusoidal compartment, hypoxia in combination with higher levels of reactive oxygen species enables proliferation of progenitor cells and their mobilization into the circulation. Because HSC niches offer protection to LSCs against chemotherapy, we review novel therapeutic strategies to inhibit homing of LSCs in niches for the prevention of dedifferentiation of leukemic cells into LSCs and to stimulate migration of leukemic cells out of niches. These strategies enhance differentiation and proliferation and thus sensitize leukemic cells to chemotherapy. Finally, we list clinical trials of therapies that tackle LSCs in HSC niches to circumvent their protection against chemotherapy.
Ključne besede:hematopoietic stem cell niche, hijacking, leukemic stem cells, bone marrow, therapy resistance, leukemia
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.08.2017
Leto izida:2017
Št. strani:str. 183-198
Številčenje:Vol. 1868, iss. 1
PID:20.500.12556/DiRROS-20138 Novo okno
UDK:61
ISSN pri članku:0304-419X
DOI:10.1016/j.bbcan.2017.03.010 Novo okno
COBISS.SI-ID:40483077 Novo okno
Datum objave v DiRROS:06.08.2024
Število ogledov:460
Število prenosov:334
Metapodatki:XML DC-XML DC-RDF
:
HIRA, Vashendriya V. V., NOORDEN, Cornelis J. F. van, CARRAWAY, Hetty E., MACIEJEWSKI, Jaroslaw P. in MOLENAAR, Remco J., 2017, Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches. Biochimica et biophysica acta CR : Reviews on cancer [na spletu]. 2017. Vol. 1868, no. 1, p. 183–198. [Dostopano 10 april 2025]. DOI 10.1016/j.bbcan.2017.03.010. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20138
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Gradivo je del revije

Naslov:Biochimica et biophysica acta CR : Reviews on cancer
Skrajšan naslov:Biochim. biophys. acta CR, Rev. cancer
Založnik:Elsevier Scientific Publ. Co.
ISSN:0304-419X
COBISS.SI-ID:14631975 Novo okno

Gradivo je financirano iz projekta

Financer:Drugi - Drug financer ali več financerjev
Program financ.:René Vogels travel grant
Financer:Drugi - Drug financer ali več financerjev
Program financ.:JoKolk scholarship
Financer:Drugi - Drug financer ali več financerjev
Program financ.:the Dutch Cancer Society grant
Številka projekta:V

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:medicinske znanosti, levkemija, zdravljenje, terapevtske strategije


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