| Title: | The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma |
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| Authors: | ID Aderetti, Diana A. (Author)
ID Hira, Vashendriya V. V. (Author)
ID Molenaar, Remco J. (Author)
ID Noorden, Cornelis J. F. van (Author) |
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| Files: |  URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S0304419X18300064?via%3Dihub
 PDF - Presentation file, download (966,30 KB)
MD5: CEC27B63274F8972507B3C6F81AC5498
URL - Source URL, visit https://doi.org/10.1016/j.bbcan.2018.04.008
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblastoma tumor samples. However, other studies have described peri-vascular niches, peri-hypoxic niches, peri-immune niches and extracellular matrix niches of GSCs. The aim of this review was to critically evaluate the literature on these five different types of GSC niches. In the present review, we describe that the five niche types are not distinct from one another, but should be considered to be parts of one integral GSC niche model, the hypoxic peri-arteriolar GSC niche. Moreover, hypoxic peri-arteriolar GSC niches are structural and functional look-alikes of hematopoietic stem cell (HSC) niches in the bone marrow. GSCs are maintained in peri-arteriolar niches by the same receptor-ligand interactions as HSCs in bone marrow. Our concept should be rigidly tested in the near future and applied to develop therapies to expel and keep GSCs out of their protective niches to render them more vulnerable to standard therapies. |
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| Keywords: | glioblastoma, glioma stem cells, niches, blood vessels, extracellular matrix, tumor microenvironment, hypoxia, therapy resistance, vasculature |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.04.2018 |
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| Year of publishing: | 2018 |
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| Number of pages: | str. 346-354 |
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| Numbering: | Vol. 1869, iss. 2 |
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| PID: | 20.500.12556/DiRROS-20136  |
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| UDC: | 577 |
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| ISSN on article: | 0304-419X |
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| DOI: | 10.1016/j.bbcan.2018.04.008 |
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| COBISS.SI-ID: | 40468741 |
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| Publication date in DiRROS: | 06.08.2024 |
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| Views: | 373 |
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| Downloads: | 221 |
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