Digital repository of Slovenian research organisations

Show document
A+ | A- | Help | SLO | ENG

Title:Epithelial-to-mesenchymal transition as the driver of changing carcinoma and glioblastoma microenvironment
Authors:ID Majc, Bernarda (Author)
ID Sever, Tilen (Author)
ID Zarić, Miki (Author)
ID Breznik, Barbara (Author)
ID Turk, Boris (Author)
ID Lah Turnšek, Tamara (Author)
Files:.pdf PDF - Presentation file, download (1,68 MB)
MD5: 7C207C2D37563E20E88955E75F634285
 
URL URL - Source URL, visit https://doi.org/10.1016/j.bbamcr.2020.118782
 
Language:English
Typology:1.02 - Review Article
Organization:Logo NIB - National Institute of Biology
Abstract:Epithelial-to-mesenchymal transition (EMT) is an essential molecular and cellular process that is part of normal embryogenesis and wound healing, and also has a ubiquitous role in various types of carcinoma and glioblastoma. EMT is activated and regulated by specific microenvironmental endogenous triggers and a complex network of signalling pathways. These mostly include epigenetic events that affect protein translation-controlling factors and proteases, altogether orchestrated by the switching on and off of oncogenes and tumour-suppressor genes in cancer cells. The hallmark of cancer-linked EMT is that the process is incomplete, as it is opposed by the reverse process of mesenchymal-to-epithelial transition, which results in a hybrid epithelial/mesenchymal phenotype that shows notable cell plasticity. This is a characteristic of cancer stem cells (CSCs), and it is of the utmost importance in their niche microenvironment, where it governs CSC migratory and invasive properties, thereby creating metastatic CSCs. These cells have high resistance to therapeutic treatments, in particular in glioblastoma.
Keywords:carcinomas, cancer stem cellsInvasion, proteases, tumour microenvironment
Publication status:Published
Publication version:Version of Record
Publication date:01.10.2020
Year of publishing:2020
Number of pages:str. 118782, 1-14
Numbering:Vol. 1867, iss. 10
PID:20.500.12556/DiRROS-20119 New window
UDC:577
ISSN on article:0167-4889
DOI:10.1016/j.bbamcr.2020.118782 New window
COBISS.SI-ID:21291011 New window
Publication date in DiRROS:06.08.2024
Views:566
Downloads:508
Metadata:XML DC-XML DC-RDF
:
MAJC, Bernarda, SEVER, Tilen, ZARIĆ, Miki, BREZNIK, Barbara, TURK, Boris and LAH TURNŠEK, Tamara, 2020, Epithelial-to-mesenchymal transition as the driver of changing carcinoma and glioblastoma microenvironment. Biochimica et biophysica acta : Molecular cell research [online]. 2020. Vol. 1867, no. 10, p. 118782, 1–14. [Accessed 18 April 2025]. DOI 10.1016/j.bbamcr.2020.118782. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20119
Copy citation
  
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Biochimica et biophysica acta : Molecular cell research
Shortened title:Biochim. biophys. acta, Mol. cell res.
Publisher:Elsevier
ISSN:0167-4889
COBISS.SI-ID:5342727 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:Z3-1870-2019
Name:Vpliv mezenhimskih matičnih celic na odpornost glioblastoma na terapijo
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-140
Funder:ARIS - Slovenian Research and Innovation Agency
Funding programme:the Slovenian Research Agency Young Researchers Programme
Funder:Other - Other funder or multiple funders
Name:Cross-Border Cooperation for Slovenia-Italy Interreg TRANS-GLIOMA

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:rakave matične celice, invazija, proteaze, tumorsko mikrookolje


Back