Digital repository of Slovenian research organisations

Show document
A+ | A- | Help | SLO | ENG

Title:Brain malignancies : glioblastoma and brain metastases
Authors:ID Lah Turnšek, Tamara (Author)
ID Novak, Metka (Author)
ID Breznik, Barbara (Author)
Files:.pdf PDF - Presentation file, download (1,83 MB)
MD5: B1330184488A239C9EC3031345F82644
 
URL URL - Source URL, visit https://doi.org/10.1016/j.semcancer.2019.10.010
 
Language:English
Typology:1.02 - Review Article
Organization:Logo NIB - National Institute of Biology
Abstract:Brain, the major organ of the central nervous system controls and processes most of body activities. Therefore, the most aggressive brain tumor – glioblastoma and metastases from other organs to the brain are lethal leaving the patients with very short time of survival. The brain tissue landscape is very different from any other tissues and the specific microenvironment, comprising stem cells niches and blood-brain barrier, significantly influences the low rate of glioblastoma metastasis out of the brain, but better accommodates brain-invading cancer. In contrast to low frequency (0.5%) of all glioblastoma metastases, 10%–45% of other primary cancers do metastasize to the brain. This review addresses general cellular and molecular pathways that are to some extent similar in both types of metastases, involving circulating tumor cells (CTCs) with cancer stem cells (CSCs) characteristics, and metastatic niches. The invasion is a dynamic process involving reversible epithelial-to-mesenchymal (EMT) cell process, creating a transient gradient state that is inter-connected with epigenetic plasticity of the metastasizing (m)CSCs. These cells can switch between stationary, low proliferating/dormant state to a migratory, mesenchymal-like state. Settling in their respective niches as dormant CSCs in the secondary organ is a common feature in all types of metastases. In glioblastoma metastasis, the malignant mGSC cells express markers of mesenchymal GSC subtype (MES-GSC), such as CD44 and YK-40 and their major obstacle seems to be propagating in the in various organs’ microenvironments, different from the niches that home GSCs in the primary glioblastoma. Focusing on one stromal component in the glioblastoma niches, the mesenchymal stem cells (MSCs), we report herein on their differential effects on glioblastoma cells, highly depending on their genetic subtype. On the other hand, in brain metastases, the major hindrance to metastatic progression of mCSCs seem to be crossing the blood-brain-barrier. Novel therapeutic approaches for brain metastases from various cancer types are advancing slowly, and the general trends involve targeting metastatic sub-clones and selective determinants of their niches. The update on the four most common brain metastases from lung, breast, melanoma and colorectal carcinoma is presented.
Keywords:glioblastoma, cancer stem cells, invasion, metastasis, tumor microenvironment
Publication status:Published
Publication version:Version of Record
Publication date:01.02.2020
Year of publishing:2020
Number of pages:str. 262-273
Numbering:Vol. 60
PID:20.500.12556/DiRROS-20116 New window
UDC:577.2
ISSN on article:1044-579X
DOI:10.1016/j.semcancer.2019.10.010 New window
COBISS.SI-ID:5208399 New window
Publication date in DiRROS:06.08.2024
Views:616
Downloads:342
Metadata:XML DC-XML DC-RDF
:
LAH TURNŠEK, Tamara, NOVAK, Metka and BREZNIK, Barbara, 2020, Brain malignancies : glioblastoma and brain metastases. Seminars in cancer biology [online]. 2020. Vol. 60, p. 262–273. [Accessed 18 April 2025]. DOI 10.1016/j.semcancer.2019.10.010. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20116
Copy citation
  
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Seminars in cancer biology
Shortened title:Semin. cancer biol.
Publisher:Saunders Scientific Publications
ISSN:1044-579X
COBISS.SI-ID:1316372 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:Z3-1870-2019
Name:Vpliv mezenhimskih matičnih celic na odpornost glioblastoma na terapijo
Funder:Other - Other funder or multiple funders
Name:Cross-Border Cooperation for Slovenia-Italy Interreg TRANS-GLIOMA

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Back