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Naslov:Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma
Avtorji:ID Panjan, Matej (Avtor)
ID Boltežar, Lučka (Avtor)
ID Novaković, Srdjan (Avtor)
ID Koković, Ira (Avtor)
ID Jezeršek Novaković, Barbara (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://pubmed.ncbi.nlm.nih.gov/37439703/
 
.pdf PDF - Predstavitvena datoteka, prenos (771,84 KB)
MD5: 6C6A257654CA1773EB8C784EDD02AAD6
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background: t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3'MBR and 5'mcr. The aim of this study was to analyze the correlation of t(14;18)(q32;q21) breakpoint site with clinical characteristics in follicular lymphoma. Patients and methods: We included patients diagnosed with follicular lymphoma who received at least 1 cycle of systemic treatment and had the t(14;18)(q32;q21) translocation detected by polymerase chain reaction (PCR) at MBR, mcr or 3'MBR prior to first treatment. Among patients with different breakpoints, sex, age, disease grade, stage, B-symptoms, follicular lymphoma international prognostic index (FLIPI), presence of bulky disease, progression free survival and overall survival were compared. Results: Of 84 patients, 63 had breakpoint at MBR, 17 at mcr and 4 at 3'MBR. At diagnosis, the MBR group had a significantly lower disease stage than the mcr group. Although not significant, in the MBR group we found a higher progression-free survival (PFS) and overall survival (OS), lower grade, age, FLIPI, and less B-symptoms. Conclusions: Compared to patients with mcr breakpoint, those with MBR breakpoint seem to be characterised by more favourable clinical characteristics. However, a larger study would be required to support our observation.
Ključne besede:clinical characteristics, follicular lymphoma, t(14, 18) translocation
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2023
Založnik:Association of Radiology and Oncology
Leto izida:2023
Št. strani:str. 487-492
Številčenje:Vol. 57, no. 4
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19843 Novo okno
UDK:616.4
ISSN pri članku:1318-2099
DOI:10.2478/raon-2023-0030 Novo okno
COBISS.SI-ID:165568259 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:25.07.2024
Število ogledov:322
Število prenosov:195
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:klinične značilnosti, folikularni limfom, translokacija t(14, 18)


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