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Title:Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma
Authors:ID Panjan, Matej (Author)
ID Boltežar, Lučka (Author)
ID Novaković, Srdjan (Author)
ID Koković, Ira (Author)
ID Jezeršek Novaković, Barbara (Author)
Files:URL URL - Source URL, visit https://pubmed.ncbi.nlm.nih.gov/37439703/
 
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MD5: 6C6A257654CA1773EB8C784EDD02AAD6
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background: t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3'MBR and 5'mcr. The aim of this study was to analyze the correlation of t(14;18)(q32;q21) breakpoint site with clinical characteristics in follicular lymphoma. Patients and methods: We included patients diagnosed with follicular lymphoma who received at least 1 cycle of systemic treatment and had the t(14;18)(q32;q21) translocation detected by polymerase chain reaction (PCR) at MBR, mcr or 3'MBR prior to first treatment. Among patients with different breakpoints, sex, age, disease grade, stage, B-symptoms, follicular lymphoma international prognostic index (FLIPI), presence of bulky disease, progression free survival and overall survival were compared. Results: Of 84 patients, 63 had breakpoint at MBR, 17 at mcr and 4 at 3'MBR. At diagnosis, the MBR group had a significantly lower disease stage than the mcr group. Although not significant, in the MBR group we found a higher progression-free survival (PFS) and overall survival (OS), lower grade, age, FLIPI, and less B-symptoms. Conclusions: Compared to patients with mcr breakpoint, those with MBR breakpoint seem to be characterised by more favourable clinical characteristics. However, a larger study would be required to support our observation.
Keywords:clinical characteristics, follicular lymphoma, t(14, 18) translocation
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2023
Publisher:Association of Radiology and Oncology
Year of publishing:2023
Number of pages:str. 487-492
Numbering:Vol. 57, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-19843 New window
UDC:616.4
ISSN on article:1318-2099
DOI:10.2478/raon-2023-0030 New window
COBISS.SI-ID:165568259 New window
Copyright:by Authors
Publication date in DiRROS:25.07.2024
Views:487
Downloads:281
Metadata:XML DC-XML DC-RDF
:
PANJAN, Matej, BOLTEŽAR, Lučka, NOVAKOVIĆ, Srdjan, KOKOVIĆ, Ira and JEZERŠEK NOVAKOVIĆ, Barbara, 2023, Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma. Radiology and oncology [online]. 2023. Vol. 57, no. 4, p. 487–492. [Accessed 7 April 2025]. DOI 10.2478/raon-2023-0030. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19843
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:klinične značilnosti, folikularni limfom, translokacija t(14, 18)


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