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Naslov:ADC values as a biomarker of fetal brain maturation
Avtorji:ID Kobal, Lucija (Avtor)
ID Šurlan Popović, Katarina (Avtor)
ID Avsenik, Jernej (Avtor)
ID Vipotnik-Vesnaver, Tina (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.radioloncol.com/index.php/ro/article/view/4043/5151
 
.pdf PDF - Predstavitvena datoteka, prenos (1,41 MB)
MD5: C93263A9E3C090F9ABC451EBA997981C
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. During the period of fetal development, myelination plays a key role and follows specific time and spa-tial sequences. The water content in the brain is inversely proportional to myelination – the more myelinated the brain, the lower the water content in it. The diffusion of water molecules can be quantitatively assessed using the apparent diffusion coefficient (ADC). We were interested in whether, by determining the ADC values, we could quantitatively evaluate the development of the fetal brain. Patients and methods. The study included 42 fetuses with gestational age 25 to 35 weeks. We manually selected 13 regions on diffusion-weighted images. Statistically significant differences between ADC values were checked using one-way analysis of variance and Tukey’s post hoc test. The relationship between the ADC values and the gestational age of the fetuses was then assessed using linear regression. Results. The average gestational age of the fetuses was 29.8 ± 2.4 weeks. ADC values in the thalami, pons and cerebellum differed significantly among each other and from the ADC values in other brain regions. In the thalami, pons and cerebellum, linear regression showed a significant decrease in ADC values with increasing gestational age. Conclusions. ADC values change with the increasing gestational age of the fetus and differ among different brain regions. In the pons, cerebellum and thalami, the ADC coefficient could be used as a biomarker of fetal brain matura-tion since ADC values decrease linearly with increasing gestational age.
Ključne besede:myelination, fetal brain maturation, ADC, biomarker, diffusion-weighted imaging, diffusion
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.06.2023
Založnik:Association of Radiology and Oncology
Leto izida:2023
Št. strani:str. 178-183
Številčenje:Vol. 57, no. 2
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19841 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
DOI:10.2478/raon-2023-0022 Novo okno
COBISS.SI-ID:165016579 Novo okno
Avtorske pravice:by Authors
Opomba:Soavtorji: Katarina Surlan Popovic, Jernej Avsenik, Tina Vipotnik Vesnaver;
Datum objave v DiRROS:25.07.2024
Število ogledov:340
Število prenosov:227
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mielinizacija, zorenje možganov ploda, biološki označevalec, difuzijsko uteženo MRI, difuzija


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